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Chemical Structure| 5298-50-0 Chemical Structure| 5298-50-0

Structure of 5298-50-0

Chemical Structure| 5298-50-0

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Product Details of [ 5298-50-0 ]

CAS No. :5298-50-0
Formula : C6H7Cl2N3
M.W : 192.05
SMILES Code : CN(C)C1=CN=C(Cl)N=C1Cl
MDL No. :MFCD15142956

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Application In Synthesis of [ 5298-50-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5298-50-0 ]

[ 5298-50-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 37454-51-6 ]
  • [ 5298-50-0 ]
YieldReaction ConditionsOperation in experiment
68% With trichlorophosphate; for 2.0h;Reflux; A solution of the aforementioned intermediate 2 (400 mg, 2.58 mmol) in POd3 (10 mL) was heated to reflux and stirred for 2 h. The mixture was cooled to room temperature and poured slowly into ice-water (100 mL). The aqueous phase was extracted with DCM (50 mL x 3). The organic layers were combined and dried over Na2SO4. The Na2SO4 was removed by filtration, and the volatileswere removed under reduced pressure, and the residue was purified by flashchromatography using a mixture of DCM and THF to give 2,4-dichloro-N,N-dimethylpyrimidin-5-amine 3 (340 mg, 68%) as a yellow oil. LRMS (M + H)m/z: calcd 192.00; found 192.
 

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