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Chemical Structure| 37465-31-9 Chemical Structure| 37465-31-9

Structure of 37465-31-9

Chemical Structure| 37465-31-9

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Product Details of [ 37465-31-9 ]

CAS No. :37465-31-9
Formula : C10H22O6P2
M.W : 300.23
SMILES Code : C=C(P(OCC)(OCC)=O)P(OCC)(OCC)=O
MDL No. :MFCD09263518
InChI Key :SLSPWQKLLPYKAB-UHFFFAOYSA-N
Pubchem ID :11022954

Safety of [ 37465-31-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 37465-31-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 37465-31-9 ]

[ 37465-31-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 80041-89-0 ]
  • [ 37465-31-9 ]
  • [ 53235-96-4 ]
  • 2
  • [ 148185-66-4 ]
  • [ 37465-31-9 ]
  • tetraethyl (2-(4,7-dibromo-1H-benzimidazol-1-yl)ethane-1,1-diyl)bisphosphonate [ No CAS ]
  • 3
  • [ 37465-31-9 ]
  • [ 271-73-8 ]
  • tetraethyl (2-(1H-pyrazolo[3,4-b]pyridin-1-yl)ethane-1,1-diyl)bisphosphonate [ No CAS ]
  • 4
  • [ 37465-31-9 ]
  • [ 78581-99-4 ]
  • tetraethyl 2-(1H-5,6-difluorobenzimidazol-1-yl)ethylidenediphosphonate [ No CAS ]
YieldReaction ConditionsOperation in experiment
In chloroform; at 20℃; for 0.5h;Inert atmosphere; General procedure: In a flame dried flask, benzimazole (1.05 equiv) was added to a solution of the vinyl carboxyphosphonate 9a or bisphosphonate 9b (1 equiv) in CHCl3 (5 mL per mmol of substrate). The solution was stirred at room temperature for 30 minutes under argon. The solvent then was removed at reduced pressure and the residue was subjected to column chromatography or used directly in the next step. If further purification was necessary, a silica column was employed with 5% EtOH in CH2Cl2 as the eluent. The yields for these Michael additions were consistently ~90%.
 

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