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Chemical Structure| 379-54-4 Chemical Structure| 379-54-4

Structure of 379-54-4

Chemical Structure| 379-54-4

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Product Details of [ 379-54-4 ]

CAS No. :379-54-4
Formula : C19H13ClF2
M.W : 314.76
SMILES Code : ClC(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3
MDL No. :MFCD17019221
InChI Key :FYPNFOAHWMDUQH-UHFFFAOYSA-N
Pubchem ID :14579825

Safety of [ 379-54-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H290
Precautionary Statements:P260-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 379-54-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 379-54-4 ]

[ 379-54-4 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 379-55-5 ]
  • [ 379-54-4 ]
YieldReaction ConditionsOperation in experiment
With acetyl chloride; In dichloromethane; at 25℃; for 12.0h; Bis(4-fluorophenyl)phenylmethanol (0.092 mol) was added to a 20% solution of acetyl chloride in dichloromethane (50 mL) at rt. The resulting purple solution was stirred for 12 h after which the solvent was removed by evaporation. Toluene (100 mL) was added to the residue and then evaporated, affording crude bis(4-fluorophenyl)phenylchloromethane which was used without purification in the following step.
  • 3
  • [ 379-54-4 ]
  • [ 2966-50-9 ]
  • [ 90173-62-9 ]
  • 4
  • [ 93-58-3 ]
  • [ 379-54-4 ]
  • 5
  • [ 352-13-6 ]
  • [ 379-54-4 ]
  • 6
  • [ 379-54-4 ]
  • [ 544-92-3 ]
  • bis(4-fluorophenyl)phenylacetonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
67% In toluene; at 100 - 140℃; for 3.16667h; Copper cyanide (8.24 g, 0.11 mol) was added to the crude residue and the mixture was heated at 140 0C for 3 h. The reaction was cooled to 100 0C and toluene (100 mL) was added. The resulting mixture was stirred vigorously for 10 min, cooled to rt, filtered through a short pad of silica and the solvent was removed under reduced pressure to afford a brown solid. Hot hexane (100 mL) was added to the powdered crude material and the mixture was stirred vigorously for 4 h. Filtration and washing with additional hexane gave the desired bis(4-fluorophenyl)phenylacetonitrile as a white solid (18.9 g, 67%).
 

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