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Chemical Structure| 380481-66-3 Chemical Structure| 380481-66-3

Structure of 380481-66-3

Chemical Structure| 380481-66-3

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Product Details of [ 380481-66-3 ]

CAS No. :380481-66-3
Formula : C12H17BO2
M.W : 204.07
SMILES Code : CC1=CC=C(B2OCC(C)(C)CO2)C=C1
MDL No. :MFCD03788728
InChI Key :ZSPBWRPQSPRISS-UHFFFAOYSA-N
Pubchem ID :23005406

Safety of [ 380481-66-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 380481-66-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 380481-66-3 ]

[ 380481-66-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 570-02-5 ]
  • [ 380481-66-3 ]
  • [ 1262967-26-9 ]
  • 2
  • [ 95-16-9 ]
  • [ 380481-66-3 ]
  • [ 16112-21-3 ]
  • 3
  • [ 2905-65-9 ]
  • [ 380481-66-3 ]
  • [ 114772-33-7 ]
YieldReaction ConditionsOperation in experiment
97% With potassium phosphate tribasic hydrate; NiIICl(1-naphthyl)(tricyclohexylphosphine)2; tricyclohexylphosphine; In tetrahydrofuran; at 23℃; for 4h;Inert atmosphere; Glovebox; Sealed tube; General procedure: Cross-Coupling of ortho-, meta-, and para-Substituted, Electron-Rich and Electron-Deficient Aryl Halides and Aryl Mesylates with Aryl Neopentylglycolboronates Catalyzed by NiIICl(1-naph-thyl)(PCy3)2/PCy3 in Anhydrous THF at 23 C; General Procedure 2In an oven-dried test tube charged with a Teflon coated stirring barwere added aryl halide or aryl mesylate (0.3 mmol), aryl neopentyl-glycolboronates (0.315 mmol), K3PO4(H2O)3.2 (191.00 ± 1.00 mg, 0.9mmol), and NiIICl(1-naphthyl)(PCy3)2 (11.73 ± 0.0510 mg, 0.015mmol, 5% catalyst loading). The test tube was brought into a N2 filledglove box (moisture level <2 ppm) through three degassing cycles andPCy3 (8.4 mg, 0.03 mmol, 10% loading) ligand was added. Distilled sol-vent (1 mL) was added inside the glove box and the test tube wassealed by a rubber septum and left stirring at 23 C. A sample was tak-en by syringe and transferred outside the glove box. The sample wasdiluted by distilled THF (0.2 mL) and filtered through a short columnof Al2O3. The filtrate was concentrated and the GC analysis was car-ried out. The reaction mixture was diluted with CH2Cl2 (2 mL), filteredthrough a layer of Al2O3, and washed with CH2Cl2 (3 1 mL). The fil-trate was collected and concentrated under vacuum. The crude prod-uct was purified by column chromatography on silica gel with EtO-Ac/hexane mixture as eluent. The reductive elimination side-productwas also isolated and characterized.
 

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