[ CAS No. 41381-89-9 ] {[proInfo.proName]}

Name: 41381-89-9|2-(4-Phenylthiazol-2-yl)acetonitrile|95%
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SKU: A574214
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Quality Control of [ 41381-89-9 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 41381-89-9 ]

Product Details of [ 41381-89-9 ]

CAS No. :	41381-89-9	MDL No. :	MFCD00551791
Formula :	C₁₁H₈N₂S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	SOFCSIBVJROWGI-UHFFFAOYSA-N
M.W :	200.26	Pubchem ID :	704539
Synonyms :

Calculated chemistry of [ 41381-89-9 ]

Physicochemical Properties

Num. heavy atoms :	14
Num. arom. heavy atoms :	11
Fraction Csp3 :	0.09
Num. rotatable bonds :	2
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	57.07
TPSA :	64.92 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.7 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.03
Log Po/w (XLOGP3) :	2.56
Log Po/w (WLOGP) :	2.88
Log Po/w (MLOGP) :	1.16
Log Po/w (SILICOS-IT) :	3.97
Consensus Log Po/w :	2.52

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.14
Solubility :	0.144 mg/ml ; 0.000718 mol/l
Class :	Soluble
Log S (Ali) :	-3.57
Solubility :	0.0538 mg/ml ; 0.000269 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.31
Solubility :	0.00988 mg/ml ; 0.0000493 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.41

Safety of [ 41381-89-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302+H312+H332-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 41381-89-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 41381-89-9 ]
Downstream synthetic route of [ 41381-89-9 ]

[ 41381-89-9 ] Synthesis Path-Upstream 1~1

1
[ 41381-89-9 ]
[ 38107-10-7 ]

Yield	Reaction Conditions	Operation in experiment
54%	Stage #1: With water; sodium hydroxide In ethanol for 1 h; Reflux Stage #2: With hydrogenchloride In ethanol; water	To a solution of Compound 18 (130 mg, 0.649 mmol) in EtOH (1.5 ml) was added 5 M NaOH solution (0.389 ml, 1.947 mmol). It was heated under reflux for 1 hour, diluted with 1M HCl aqueous solution (5 ml), and extracted with chloroform (10 ml) five times. The organic layer was dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified with silicagel chromatography (CHCl₃: MeOH : AcOH = 10 : 1 : 0.1) to give Compound 19 (77.2 mg, 54 percent) as brown oil. ¹H-NMR(DMSO-d₆): δ(ppm) 4.13 (s, 2H), 7.30-7.37 (m, 1H), 7.39-7.47 (m, 2H), 7.90-7.97 (m, 2H), 8.04 (s, 1H), 12.81 (brs, 1H)

Reference： [1] Patent: EP2351744, 2011, A1, . Location in patent: Page/Page column 60

[ 41381-89-9 ] Synthesis Path-Downstream 1~88

1
[ 108-94-1 ]
[ 41381-89-9 ]
[ 54317-43-0 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

2
[ 141-97-9 ]
[ 41381-89-9 ]
[ 54317-45-2 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

3
[ 100-52-7 ]
[ 41381-89-9 ]
[ 72740-58-0 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

4
[ 123-11-5 ]
[ 41381-89-9 ]
[ 115071-97-1 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

5
[ 98-88-4 ]
[ 41381-89-9 ]
[ 54317-33-8 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

6
[ 103-72-0 ]
[ 41381-89-9 ]
2-cyano-N-phenyl-2-(4-phenyl-thiazol-2-yl)-thioacetamide [ No CAS ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

7
[ 2757-23-5 ]
[ 41381-89-9 ]
[ 54317-47-4 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

8
[ 75-36-5 ]
[ 41381-89-9 ]
[ 54317-35-0 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

9
[ 7357-70-2 ]
[ 70-11-1 ]
[ 41381-89-9 ]

Yield	Reaction Conditions	Operation in experiment
87%	In DMF (N,N-dimethyl-formamide); at 70℃; for 1h;	To a solution of [CC-CYANOTHIOACETAMIDE] (0.5 g, 5 mmol) in DMF (3 mL) [A-BROMOACETOPHENONE] (1 g, [5] mmol, dissolved in 3 mL of DMF) was slowly added (dropping funnel). Approximately 30min after the addition the mixture was heated to [70C] for 30min, after which the reaction was complete as judged by TLC (SiO2; hexane/AcOEt 8: 2, [RF=0.] 3) The dark solution was poured onto water (50 mL) and extracted with AcOEt (3 x 30 mL). The combined organic phases were dried over [NA2SO4] and concentrated under vacuum. The resultant oily residue was dissolved in EtOH (2 mL) and poured in water (30 mL). After 1 hour stirring at room temperature the formed solid was filtered off, washed with [H20] and dried under vacuum (2 h, [50C] ; 48 h, [25C).] Pure [4-phenylthiazol-2-yl] acetonitrile (3,0. 87 g, 87%) was obtained. Analytical data ['H-NMR] [(DMSO-D6,] [8)] : 7.9 (bd, 2H); 7.26-7. 5 [(M,] 4H); 4.2 (s, 2H) M. P. = [60C]
75%		Step 2: 2-(4-Phenylthiazol-2-yl)acetonitrileA mixture of 2-bromoacetophenone (2 g, 10 mmol) and 2-cyanothioacetamide (1 g, 10 mmol) in EtOH (25 ml.) was heated to 80 C for 4 h. The reaction mixture was cooled to room temperature and poured into an aqueous ammonia solution (final pH was >7). The mixture was then extracted with EtOAc and the organic layer was washed with H20 and brine. Solvent was removed under reduced pressure and the crude product was purified by flash column chromatography (silica gel 230-400 mesh, eluent 8% EtOAc in petroleum ether) to afford 2-(4-phenylthiazol-2-yl)acetonitrile (1.5 g, yield 75%) as a yellow solid: 1H NMR (300MHz, CDCI3) delta 7.88-7.91 (m, 2H), 7.49 (s, 1 H), 7.27-7.48 (m, 3H), 4.19 (s, 2H). MS (ESI) m/z: Calculated for CnH8N2S: 200.04; found: 201 .2 (M+H)+.
75%	In ethanol; at 80℃; for 4h;	A mixture of 2-bromoacetophenone (2 g, 10 mmol) and 2-cyanothioacetamide (1 g, 10 mmol) in EtOH (25 mL) was heated to 80 C for 4 h. The reaction mixture was cooled to room temperature and poured into an aqueous ammonia solution (final pH was >7). The mixture was then extracted with EtOAc and the organic layer was washed with H2O and brine. Solvent was removed under reduced pressure and the crude product was purified by flash column chromatography (silica gel 230-400 mesh, eluent 8% EtOAc in petroleum ether) to afford 2-(4-phenylthiazol-2-yl)acetonitrile (1.5 g, yield 75%) as a yellow solid: 1H NMR (300MHz, CDCl3) delta 7.88-7.91 (m, 2H), 7.49 (s, 1H), 7.27-7.48 (m, 3H), 4.19 (s, 2H). MS (ESI) m/z: Calculated for C11H8N2S: 200.04; found: 201.2 (M+H)+.

71%	With triethylamine; In tetrahydrofuran; at 20℃;	General procedure: The corresponding 2-bromo-1-(aryl)ethan-1-one derivative (0.02 mol, 1 equiv.) and 2-cyanothioacetamide (0.02 mol, 1 equiv.) were dissolved in dry THF (50 mL) followed by the addition of Et3N (0.022 mol, 1.1 equiv.) (precipitation of a white solid). The reaction mixture was left to react at room temperature overnight. The solid was filtered off and the filtrate was concentrated on a rotary evaporator. The residue was dissolved in EtOAc (200 mL) and washed with water (2 50 mL), saturated aqueous solution of NaHCO3 (2 50 mL), and brine (50 mL), and dried over Na2SO4. The solvent was evaporated under reduced pressure. The crude product was purified by flash chromatography (EtOAc:hexane, 1:8) to give the desired product (71%) as a dark yellow solid. Mp = 50-51 C. 1H NMR (400 MHz, CDCl3): delta (ppm) 4.15 (s, 2H), 7.32-7.37 (m, 1H), 7.39-7.44 (m, 2H), 7.46 (s, 1H), 7.84-7.88 (m, 2H).
70%	In ethanol; at 80℃; for 4h;	2-(4-phenylthiazol-2-yl)acetonitrile A mixture of 2-bromoacetophenone (1 .0 g, 5 mmol) and 2- cyanothioacetamide (0.5 g, 10 mmol) in ethanol (25 mL) was heated to 80C for 4 h. The reaction mixture was cooled to room temperature and poured into an aqueous ammonia solution (final pH was >7). The mixture was then extracted with ethyl acetate (100 mL x 3) and the organic layers were washed with H2O and brine. The organic layers were dried over anhydrous magnesium sulfate, filtered, and concentrate in vacuo. The crude product was purified by flash column chromatography, eluting with 0-30% ethyl acetate and petroleum benzene, afforded 2-(4-phenylthiazol-2-yl)acetonitrile (0.69 g, yield 70%) as a yellow solid.
1 g	In N,N-dimethyl-formamide; at 20 - 70℃; for 1.58333h;	To a stirred solution of 5 2-cyanoethanethioamide (500 mg, 5.00 mmol) in 6 DMF (3 mL) was added drop wise a solution of 7 2-bromo-1-phenylethan-1-one (1 g, 5.00 mmol) in DMF (3 mL) at room temperature, and the reaction was stirred for another 50 min. The resulting solution was heated at 70 C. for 45 min, and the reaction was monitored by TLC. After the completion, the reaction mixture was diluted with EtOAc, washed with water, dried over anhydrous Na2SO4 and filtered. The 8 filtrate obtained was concentrated under reduced pressure to get a crude residue which was purified by silica-gel column chromatography eluting with 0-7% ethyl acetate in n-hexane to afford 1 g of the desired compound. LCMS: [M+H]+=200.95. 1H NMR (CDCl3, 400 MHz): delta 7.88 (d, J=7.48 Hz, 2H), 7.48 (s, 1H), 7.41-7.47 (m, 2H), 7.37 (d, J=7.48 Hz, 1H), 4.18 (s, 2H).

Reference： [1]Patent: WO2003/105842,2003,A1 .Location in patent: Page 65 - 66
[2]Patent: WO2011/88187,2011,A1 .Location in patent: Page/Page column 36
[3]Patent: EP2533783,2015,B1 .Location in patent: Paragraph 0129-0130
[4]European Journal of Medicinal Chemistry,2016,vol. 112,p. 252 - 257
[5]Patent: WO2015/172196,2015,A1 .Location in patent: Paragraph 0038; 00232
[6]Russian Chemical Bulletin,2007,vol. 56,p. 1441 - 1446
[7]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692
[8]Patent: US2019/48019,2019,A1 .Location in patent: Paragraph 0152; 0153; 0154

10
[ 75-15-0 ]
[ 70-11-1 ]
[ 41381-89-9 ]
[ 54317-37-2 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

11
[ 100-10-7 ]
[ 41381-89-9 ]
3-(4-dimethylamino-phenyl)-2-(4-phenyl-thiazol-2-yl)-acrylonitrile [ No CAS ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

12
[ 75-15-0 ]
[ 77-78-1 ]
[ 41381-89-9 ]
[ 54317-39-4 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

13
[ 123-54-6 ]
[ 41381-89-9 ]
[ 54317-44-1 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

14
[ 103-80-0 ]
[ 41381-89-9 ]
[ 54317-34-9 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

15
[ 79-37-8 ]
[ 41381-89-9 ]
[ 54317-46-3 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

16
[ 100-34-5 ]
[ 41381-89-9 ]
[ 112672-50-1 ]

Reference： [1]Egyptian Journal of Chemistry,1994,vol. 37,p. 509 - 518
[2]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117
[3]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

17
[ 115071-97-1 ]
[ 41381-89-9 ]

Reference： [1]Tetrahedron,1988,vol. 44,p. 241 - 246

18
[ 30742-60-0 ]
[ 41381-89-9 ]
C₂₃H₂₀N₄O₂S [ No CAS ]

Reference： [1]Synthesis,2007,p. 2872 - 2886

19
[ 68820-12-2 ]
[ 41381-89-9 ]
N-{2-[cyano(4-phenyl-1,3-thiazol-2-yl)methyl]cyclohexyl}-4-methylbenzenesulfonamide [ No CAS ]

Reference： [1]Organic Letters,2007,vol. 9,p. 4677 - 4680

20
[ 41381-89-9 ]
4-(butyl-methyl-amino)-3-oxo-2-(4-phenyl-3H-thiazol-2-ylidene)-butyronitrile [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

21
[ 41381-89-9 ]
4-(cyclohexyl-methyl-amino)-3-oxo-2-(4-phenyl-3H-thiazol-2-ylidene)-butyronitrile [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

22
[ 41381-89-9 ]
4-dibutylamino-3-oxo-2-(4-phenyl-3H-thiazol-2-ylidene)-butyronitrile [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

23
[ 41381-89-9 ]
1-[3-cyano-2-oxo-3-(4-phenyl-3H-thiazol-2-ylidene)-propyl]-piperidine-4-carboxylic acid amide [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

24
[ 41381-89-9 ]
1-[3-cyano-2-oxo-3-(4-phenyl-3H-thiazol-2-ylidene)-propyl]-piperidine-3-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

25
[ 41381-89-9 ]
4-(4-benzyl-piperidin-1-yl)-3-oxo-2-(4-phenyl-3H-thiazol-2-ylidene)-butyronitrile [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

26
[ 41381-89-9 ]
4-(4-benzyl-piperazin-1-yl)-3-oxo-2-(4-phenyl-3H-thiazol-2-ylidene)-butyronitrile [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

27
[ 41381-89-9 ]
4-[4-(2-fluoro-phenyl)-piperazin-1-yl]-3-oxo-2-(4-phenyl-3H-thiazol-2-ylidene)-butyronitrile [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

28
[ 41381-89-9 ]
4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-3-oxo-2-(4-phenyl-3H-thiazol-2-ylidene)-butyronitrile [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

29
[ 41381-89-9 ]
4-dihexylamino-3-oxo-2-(4-phenyl-3H-thiazol-2-ylidene)-butyronitrile [ No CAS ]

Reference： [1]Chemistry of Heterocyclic Compounds,2001,vol. 37,p. 1011 - 1020

30
[ 41381-89-9 ]
5-amino-4-(4-phenyl-thiazol-2-yl)-1-o-tolyl-1,2-dihydro-pyrrol-3-one [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

31
[ 41381-89-9 ]
5-amino-4-(4-phenyl-thiazol-2-yl)-1-p-tolyl-1,2-dihydro-pyrrol-3-one [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

32
[ 41381-89-9 ]
5-amino-4-(4-phenyl-thiazol-2-yl)-1-m-tolyl-1,2-dihydro-pyrrol-3-one [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

33
[ 41381-89-9 ]
5-amino-1-(2-fluoro-phenyl)-4-(4-phenyl-thiazol-2-yl)-1,2-dihydro-pyrrol-3-one [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

34
[ 41381-89-9 ]
5-amino-1-(4-isopropyl-phenyl)-4-(4-phenyl-thiazol-2-yl)-1,2-dihydro-pyrrol-3-one [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

35
[ 41381-89-9 ]
5-amino-1-(2,4-difluoro-phenyl)-4-(4-phenyl-thiazol-2-yl)-1,2-dihydro-pyrrol-3-one [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

36
[ 41381-89-9 ]
5-amino-1-(4-phenoxy-phenyl)-4-(4-phenyl-thiazol-2-yl)-1,2-dihydro-pyrrol-3-one [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

37
[ 41381-89-9 ]
{4-[5-amino-3-oxo-4-(4-phenyl-thiazol-2-yl)-2,3-dihydro-pyrrol-1-yl]-phenyl}-acetic acid ethyl ester [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

38
[ 41381-89-9 ]
5-amino-4-(4-phenyl-thiazol-2-yl)-1-(4-piperidin-1-yl-phenyl)-1,2-dihydro-pyrrol-3-one [ No CAS ]

Reference： [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 1323 - 1329

39
[ 41381-89-9 ]
(5-acetyl-3-phenyl-3H-[1,3,4]thiadiazol-2-ylidene)-(4-phenyl-thiazol-2-yl)-acetonitrile [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

40
[ 41381-89-9 ]
[5-acetyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-2-ylidene]-(4-phenyl-thiazol-2-yl)-acetonitrile [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

41
[ 41381-89-9 ]
5-[1-Cyano-1-(4-phenyl-thiazol-2-yl)-meth-(E)-ylidene]-4-phenyl-4,5-dihydro-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

42
[ 41381-89-9 ]
(5-acetyl-3-p-tolyl-3H-[1,3,4]thiadiazol-2-ylidene)-(4-phenyl-thiazol-2-yl)-acetonitrile [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

43
[ 41381-89-9 ]
(5-benzoyl-3-phenyl-3H-[1,3,4]thiadiazol-2-ylidene)-(4-phenyl-thiazol-2-yl)-acetonitrile [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

44
[ 41381-89-9 ]
4-(4-Chloro-phenyl)-5-[1-cyano-1-(4-phenyl-thiazol-2-yl)-meth-(E)-ylidene]-4,5-dihydro-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

45
[ 41381-89-9 ]
5-[1-Cyano-1-(4-phenyl-thiazol-2-yl)-meth-(E)-ylidene]-4-p-tolyl-4,5-dihydro-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

46
[ 41381-89-9 ]
5-[1-Cyano-1-(4-phenyl-thiazol-2-yl)-meth-(E)-ylidene]-4-phenyl-4,5-dihydro-[1,3,4]thiadiazole-2-carboxylic acid phenylamide [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

47
[ 41381-89-9 ]
[5-benzoyl-3-(4-chloro-phenyl)-3H-[1,3,4]thiadiazol-2-ylidene]-(4-phenyl-thiazol-2-yl)-acetonitrile [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1999,vol. 152,p. 115 - 128

48
[ 41381-89-9 ]
(phenyl-hydrazono)-(4-phenyl-5-phenylazo-thiazol-2-yl)-acetonitrile [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

49
[ 41381-89-9 ]
(4-phenyl-5-phenylazo-thiazol-2-yl)-(p-tolyl-hydrazono)-acetonitrile [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

50
[ 41381-89-9 ]
2-(4-furan-2-yl-2,5-diphenyl-2H-pyrazol-3-yl)-4-phenyl-thiazole [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

51
[ 41381-89-9 ]
2-(2,5-diphenyl-4-thiophen-2-yl-2H-pyrazol-3-yl)-4-phenyl-thiazole [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

52
[ 41381-89-9 ]
[ 277308-36-8 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

53
[ 41381-89-9 ]
[ 277308-37-9 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

54
[ 41381-89-9 ]
2-(2,5-diphenyl-4-p-tolyl-2H-pyrazol-3-yl)-4-phenyl-thiazole [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

55
[ 41381-89-9 ]
[ 277308-34-6 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

56
[ 41381-89-9 ]
1-phenyl-5-(4-phenyl-thiazol-2-yl)-4-p-tolyl-1H-pyrazole-3-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

57
[ 41381-89-9 ]
2-[4-(4-chloro-phenyl)-2,5-diphenyl-2H-pyrazol-3-yl]-4-phenyl-thiazole [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

58
[ 41381-89-9 ]
[ 277308-39-1 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

59
[ 41381-89-9 ]
[ 277308-35-7 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

60
[ 41381-89-9 ]
1-phenyl-5-(4-phenyl-thiazol-2-yl)-4-p-tolyl-1H-pyrazole-3-carboxylic acid phenylamide [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

61
[ 41381-89-9 ]
[ 277308-40-4 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,1998,vol. 133,p. 103 - 117

62
[ 41381-89-9 ]
diethyl 1,2-dihydro-6-(4'-phenylthiazol-2'-ylmethyl)-2-oxo-pyridine-4,5-dicarboxylate [ No CAS ]

Reference： [1]Journal fur Praktische Chemie (Weinheim),1999,vol. 341,p. 147 - 151

63
[ 41381-89-9 ]
ethyl 6-(4'-phenylthiazol-2'-ylmethyl)-2-oxo-1,2,3,4-tetrahydro-4-thioxopyrimidine-5-carboxylate [ No CAS ]

Reference： [1]Journal fur Praktische Chemie (Weinheim),1999,vol. 341,p. 147 - 151

64
[ 41381-89-9 ]
[ 222056-83-9 ]

Reference： [1]Journal fur Praktische Chemie (Weinheim),1999,vol. 341,p. 147 - 151

65
[ 41381-89-9 ]
5-hydroxy-4-(4'-phenylthiazol-2'-yl)methyl-2-phenylthieno<2,3-d>pyrimidine-6-carbonitrile [ No CAS ]

Reference： [1]Journal fur Praktische Chemie (Weinheim),1999,vol. 341,p. 147 - 151

66
[ 41381-89-9 ]
2,6-diphenyl-8-(4'-phenylthiazol-2'-yl)-3,4,5,6-tetrahydro-4-thioxopyrimido<4,5-d>pyridazin-5-one [ No CAS ]

Reference： [1]Journal fur Praktische Chemie (Weinheim),1999,vol. 341,p. 147 - 151

67
[ 41381-89-9 ]
diethyl 1,4-dihydro-2,6-di(4'-phenylthiazol-2'-ylmethyl)-4-phenylpyridine-3,5-dicarboxylate [ No CAS ]

Reference： [1]Journal fur Praktische Chemie (Weinheim),1999,vol. 341,p. 147 - 151

68
[ 41381-89-9 ]
(Z)-3-(4-Chloro-phenyl)-2-(4-phenyl-5-phenylazo-thiazol-2-yl)-acrylonitrile [ No CAS ]

Reference： [1]Journal of Chemical Research - Part S,1995,p. 144 - 145

69
[ 41381-89-9 ]
4-amino-1,6-dihydro-6-imino-3-(4-phenylthiazol-2-yl)-pyridazin-5-carbonitrile [ No CAS ]

Reference： [1]Egyptian Journal of Chemistry,1994,vol. 37,p. 509 - 518

70
[ 70-11-1 ]
[ 41381-89-9 ]

Reference： [1]Tetrahedron,1988,vol. 44,p. 241 - 246

71
[ 41381-89-9 ]
[ 54317-36-1 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

72
[ 41381-89-9 ]
[ 1826-16-0 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1974,vol. 316,p. 684 - 692

73
[ 41381-89-9 ]
[ 95-01-2 ]
[ 320741-52-4 ]

Yield	Reaction Conditions	Operation in experiment
52%	piperidine; In ethanol; at 20℃;Heating / reflux;	To a mixture of (4-phenylthiazol-2-yl) acetonitrile (compound of Description 3, 2.5 g, 12.5 mmol) and 2,4-dihydroxybenzaldehyde (from Aldrich, 1.72 g, 12.5 mmol) in absolute ethanol (30 mL) piperidine (8 drops) was added and the mixture was refluxed for 4 hour. The reaction completion was checked by TLC [(SITZ] ; hexane/AcOEt 1: 1, Rf =0. 3). The mixture was stirred overnight at room temperature. Then the precipitated solid, which corresponded to the imino derivative intermediate, was filtered off, washed with EtOH and dried under vacuum (2 h, [50C).] The resultant crude material was chromatographed on Si02 column (eluent hexane/AcOEt 6: 4) to yield, after crystallization from EtOH/AcOEt 1 : [1,] 2.1 g of pure imino compound which was characterised [BY'H-NMR [DMSO-D,, 8] : 8.8 (s, 1H) ; 8.6 (s, [1H,] =N-H); 8.15 (s, [1H,] [THIAZ-H)] ; 8.1 (d, 2H); 7.6 (d, 1H); 7.5 (t, 2H); 7.4 (d, [1H)] ; 6.7 (dd, [1H)] ; 6.6 (d, [1H)].] The so obtained solid (2.1 g, 52% yield) was suspended in [WATER/ACOH] 1: 1 (25 mL) and refluxed for 2 hours. The reaction was complete in TLC [(SIO2] ; hexane/AcOEt 6: 4, [RF=0.] 8). The suspension was cooled to room temperature and the solid removed by filtration. After several washings with water the resultant solid was dried under vacuum (4 h, [40C)] to yield pure [3- [4-PHENYLTHIAZOL-2-YL]-7-HYDROXY-] chromen-2-one (1.98 g, 49% yield). Analytical data ['H-NMR] [(DMSO-D6,] [8)] : 9.1 (s, 1H); 8.2 (s, 1H, Thiaz-H); 8.1 (d, 2H); 7.9 (d, 1H) ; 7.3-7. 55 (m, 3H); 6.9 (dd, 1H) ; 6.85 (d, 1H) Elemental analysis: found % (theoretical %); C 67.25 (67.28) ; H 3.42 (3.45) ; [N 4.] 38 (4.36) ; S 10.06 (9.98) M. P. =>300C

Reference： [1]Patent: WO2003/105842,2003,A1 .Location in patent: Page 80 - 81

74
[ 37470-87-4 ]
[ 41381-89-9 ]
[ 320741-53-5 ]

Yield	Reaction Conditions	Operation in experiment
77%	piperidine; In ethanol; for 1h;Heating / reflux;	To a mixture of 4-phenylthiazol-2-yl) acetonitrile (compound of Description 3,0. 5 g, 2.49 mmol) and 5-hexyl-4-hydroxysalicyl-aldehyde (compound of Description 1,0. 55 g, 2.49 mmol) in absolute ethanol (20 mL) piperidine (8 drops) was added and the mixture was refluxed for 1 hour. The reaction completion was checked by TLC (Si02 [; HEXANE/ACOET] 1: [1,] [RF=0.] 2). After cooling the precipitated solid, which corresponded to the imino derivative intermediate, was filtered off, washed with i-PrOH and dried under vacuum (2 h, [50C).] The so obtained brownish solid (0.78 g, 77% yield) was suspended in water/AcOH 1: 1 (25 mL) and refluxed for 3.5 hours. The reaction was complete in TLC (hexane/AcOEt 6: 4, [RIF-0.] 8). The suspension was cooled to room temperature and the solid removed by filtration. After several washings with water the yellowish solid was dried under vacuum (2 h, [50C] ; 72 h, [25C)] to yield pure [3- [4-PHENYLTHIAZOL-2-YL]-] [6- (N-HEXYL)-7-HYDROXY-CHROMEN-2-ONE] (0.73 g, 73% yield). Analytical data ['H-NMR] [(DMSO-D6,] [8)] : 9.0 (s, 1H) ; 8.2 (s, 1H) ; 8.1 (d, 2H); 7.7 (s, [1H)] ; 7.4-7. 5 (m, [3H)] ; 6.8 (s, [1H)] ; 2.6 (t, 2H); 1.6 (m, [2H) ;] 1.3 (m, 6H); 0.9 (bt, 3H) Elemental analysis: found % (theoretical %); C 69.82 (71. [09) ;] H 5.81 (5.72) ; N 3.46 (3.45) ; S 7.71 (7.91) M. P. = [220-230C]

Reference： [1]Patent: WO2003/105842,2003,A1 .Location in patent: Page 75 - 76

75
[ 17754-90-4 ]
[ 41381-89-9 ]
[ 72404-46-7 ]

Yield	Reaction Conditions	Operation in experiment
	piperidine; In ethanol; for 0.666667h;Heating / reflux;	To a mixture of (4-phenylthiazol-2-yl) acetonitrile (compound of Description 3,1. 6 g, 7.98 mmol) and 4- (N, N-diethylamino) salicylaldehyde (from Aldrich, 1.54 g, 7.98 mmol) in absolute ethanol (30 mL) piperidine (8 drops) was added and the mixture was refluxed for 40'. The reaction turned rapidly to dark and its completion was checked by TLC [(SI02] ; hexane/AcOEt 6: 4, [RIF-0.] 2). The mixture, which corresponded to the imino derivative intermediate, was concentrated under vacuum to a dark-brown oily residue. The sticky material was diluted with water/AcOH 1: 1 (50 mL) and refluxed for 4 hours. The reaction was complete in TLC [(SI02] ; hexane/AcOEt 6: 4, [RF=0.] 8). The suspension was cooled to room temperature and the precipitated solid was filtered off and washed several times with water. After drying under vacuum (3 h, [50C] ; 16 h, [25C)] pure [3- [4-PHENYLTHIAZOL-2-YL]-7- (N,] N- diethylamino) -chromen-2-one (2.8 g, 93% yield) was achieved. Analytical data [1H-NMR] [(DMSO-D6,] [6)] : 8.9 (s, [1H) ;] 8.1 (s+d, [1H+2H)] ; 7.75 (d, 1H); 7.4 (m, 3H); 6.8 (d, 1H); 6.65 (s, 1H); 3.5 (q, 4H); 1.15 (t, 6H) Elemental analysis: found % (theoretical %); C 70.14 (70.19) ; H 5.33 (5.35) ; N 7.52 (7.44) ; S 8.73 (8.52) M. P. = [125-126C]

Reference： [1]Patent: WO2003/105842,2003,A1 .Location in patent: Page 79 - 80

76
[ 59938-06-6 ]
[ 41381-89-9 ]
[ 1009099-66-4 ]
C₁₇H₁₃F₃N₂OS [ No CAS ]

Reference： [1]Synthesis,2007,p. 3797 - 3806

77
[ 14338-32-0 ]
[ 41381-89-9 ]
[ 1046768-31-3 ]

Reference： [1]Synthesis,2008,p. 1541 - 1544

78
[ 1147101-52-7 ]
[ 41381-89-9 ]
[ 1147101-72-1 ]

Reference： [1]Tetrahedron,2009,vol. 65,p. 2678 - 2683

79
[ 1147101-53-8 ]
[ 41381-89-9 ]
[ 1147101-75-4 ]

Reference： [1]Tetrahedron,2009,vol. 65,p. 2678 - 2683

80
[ 1147101-51-6 ]
[ 41381-89-9 ]
[ 1147101-65-2 ]

Reference： [1]Tetrahedron,2009,vol. 65,p. 2678 - 2683

81
[ 863891-27-4 ]
[ 41381-89-9 ]
[ 1147101-70-9 ]

Reference： [1]Tetrahedron,2009,vol. 65,p. 2678 - 2683

82
[ 1516-60-5 ]
[ 41381-89-9 ]
[ 1198208-56-8 ]

Reference： [1]Chemistry of Heterocyclic Compounds,2009,vol. 45,p. 483 - 488

83
[ 622-37-7 ]
[ 41381-89-9 ]
[ 163071-24-7 ]

Reference： [1]Chemistry of Heterocyclic Compounds,2009,vol. 45,p. 483 - 488

84
3-azido-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylic acid ethyl ester [ No CAS ]
[ 41381-89-9 ]
[ 1210306-13-0 ]

Reference： [1]Chemistry of Heterocyclic Compounds,2009,vol. 45,p. 881 - 883

85
[ 16714-23-1 ]
[ 41381-89-9 ]
[ 1228017-75-1 ]

Reference： [1]Journal of Heterocyclic Chemistry,2010,vol. 47,p. 415 - 420

86
[ 1826-23-9 ]
[ 75-05-8 ]
[ 41381-89-9 ]

Yield	Reaction Conditions	Operation in experiment
72%		1.9 M NaHMDS/THF solution (8.07 ml, 15.33 mmol) was diluted with absolute THF (10ml) at - 60 C. To the solution was dropped acetonitrile (531 mul, 10.22 mmol). It was stirred for 30 minutes. To the mixture was dropped the solution of Compound 17 (1 g, 5.11 mmol) in absolute THF (10ml). It was stirred for 1 hour at 0 C. The mixture was diluted with 2M HCl (10 ml) and extracted with ethyl acetate (50 ml). The oil layer was washed with brine (50ml). The solvent was evaporated under reduced pressure. The residue was purified with silicagel chromatography (n-hexane : ethyl acetate = 4 : 1) to give Compound 18 (740 mg, 72 %) as a green solid. 1H-NMR(DMSO-d6): delta (ppm) 4.63 (s, 2H), 7.33-7.40 (m, 1H), 7.42-7.51 (m, 2H), 7.90- 8.00 (m, 2H), 8.13 (s, 1H).

Reference： [1]Patent: EP2351744,2011,A1 .Location in patent: Page/Page column 59-60

87
[ 41381-89-9 ]
[ 38107-10-7 ]

Yield	Reaction Conditions	Operation in experiment
54%		To a solution of Compound 18 (130 mg, 0.649 mmol) in EtOH (1.5 ml) was added 5 M NaOH solution (0.389 ml, 1.947 mmol). It was heated under reflux for 1 hour, diluted with 1M HCl aqueous solution (5 ml), and extracted with chloroform (10 ml) five times. The organic layer was dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified with silicagel chromatography (CHCl3: MeOH : AcOH = 10 : 1 : 0.1) to give Compound 19 (77.2 mg, 54 %) as brown oil. 1H-NMR(DMSO-d6): delta(ppm) 4.13 (s, 2H), 7.30-7.37 (m, 1H), 7.39-7.47 (m, 2H), 7.90-7.97 (m, 2H), 8.04 (s, 1H), 12.81 (brs, 1H)

Reference： [1]Patent: EP2351744,2011,A1 .Location in patent: Page/Page column 60

88
[ 5414-19-7 ]
[ 41381-89-9 ]
[ 1314886-95-7 ]

Yield	Reaction Conditions	Operation in experiment
85%		-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-carbonitrileA solution of 2-(4-phenylthiazol-2-yl)acetonitrile (0.84 g, 4.19 mmol) in THF (25 ml.) was cooled to 0 C. NaH was added (0.5 g, 60% dispersion in oil) portionwise over 10 min. The resulting mixture was allowed to warm up to room temperature and stirred for 20 min. 2-Bromoethyl ether (1.58 ml_, 12.5 mmol) was added dropwise. The reaction mixture was further stirred at room temperature for 1 h and then quenched with saturated NH4CI solution. The reaction mixture was diluted with EtOAc and the organic layer was washed with H20 and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel 60-120 mesh, eluent 4-8% EtOAc in petroleum ether) to afford 4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-carbonitrile (0.97 g, yield 85%) as a yellow solid: 1 H NMR (300 MHz, CDCI3) delta 7.91 -7.94 (m, 2H), 7.51 (s, 1 H), 7.37-7.48 (m, 3H), 4.07-4.14 (m, 2H), 3.87-3.96 (m, 2H), 2.32-2.43 (m, 4H). MS (ESI) m/z: Calculated for C15H14N2OS: 270.08; found: 271 .2 (M+H)+.
85%		A solution of 2-(4-phenylthiazol-2-yl)acetonitrile (0.84 g, 4.19 mmol) in THF (25 mL) was cooled to 0 C. NaH was added (0.5 g, 60% dispersion in oil) portionwise over 10 min. The resulting mixture was allowed to warm up to room temperature and stirred for 20 min. 2-Bromoethyl ether (1.58 mL, 12.5 mmol) was added dropwise. The reaction mixture was further stirred at room temperature for 1 h and then quenched with saturated NH4Cl solution. The reaction mixture was diluted with EtOAc and the organic layer was washed with H2O and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel 60-120 mesh, eluent 4-8% EtOAc in petroleum ether) to afford 4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-carbonitrile (0.97 g, yield 85%) as a yellow solid: 1H NMR (300 MHz, CDCl3) delta 7.91-7.94 (m, 2H), 7.51 (s, 1 H), 7.37-7.48 (m, 3H), 4.07-4.14 (m, 2H), 3.87-3.96 (m, 2H), 2.32-2.43 (m, 4H). MS (ESI) m/z: Calculated for C15H14N2OS: 270.08; found: 271.2 (M+H)+.

Reference： [1]Patent: WO2011/88187,2011,A1 .Location in patent: Page/Page column 36-37
[2]Patent: EP2533783,2015,B1 .Location in patent: Paragraph 0130-0131

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P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 41381-89-9 ] {[proInfo.proName]}

Quality Control of [ 41381-89-9 ]

Related Doc. of [ 41381-89-9 ]

Product Details of [ 41381-89-9 ]

Calculated chemistry of [ 41381-89-9 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 41381-89-9 ]

Application In Synthesis of [ 41381-89-9 ]

[ 41381-89-9 ] Synthesis Path-Upstream 1~1

[ 41381-89-9 ] Synthesis Path-Downstream 1~88

Related Functional Groups of [ 41381-89-9 ]

Aryls

Nitriles

Related Parent Nucleus of [ 41381-89-9 ]

Thiazoles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 41381-89-9 ]

Related Parent Nucleus of
[ 41381-89-9 ]