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CAS No. : | 38404-42-1 | MDL No. : | MFCD00219861 |
Formula : | C10H12O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | PTSSKYUSCIALKU-UHFFFAOYSA-N |
M.W : | 164.20 | Pubchem ID : | 520902 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With thionyl chloride; In N,N-dimethyl-formamide; at 25℃; for 12h; | Thionyl chloride (80 ml; 2 equiv.) was added at room temperature to a solution of <strong>[619-04-5]3,4-dimethylbenzoic acid</strong> (35 g; 1 equiv.) and dimethylformamide (1 ml) in 227 ml of methanol. The resulting reaction mixture was stirred for 12 h at room temperature and then concentrated under reduced pressure. The resulting residue was taken up in dichloromethane and washed with 5% sodium carbonate solution. The organic phase was dried over magnesium sulfate and concentrated under reduced pressure. The methyl 3,4-dimethylbenzoate so obtained (38.2 g) was used in the next stage without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With oxone||potassium monopersulfate triple salt; potassium bromide; In dichloromethane; water; at 0 - 25℃; for 14h; | To a stirred solution of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong> (22.00 g, 134 mmol), dichloromethane (200 mL) and water (200 mL), oxone (196 g, 268 mmol) was added followed by portion wise addition of potassium bromide (KBr) (39.9 g, 335 mmol) at 0 C. The resulting reaction mixture was stirred for 14 h at 25 C. The reaction mixture was then diluted with water and extracted with dichloromethane. The combined organic fractions were evaporated under reduced pressure to obtain a crude material, which was then triturated in n-pentane. The organic solvent (pentane phase) was decanted and the solid was dried at reduced pressure to afford methyl 3,4-bis(bromomethyl)benzoate (30 g, 93 mmol, 69 % yield) as a white solid. -NMR (400 MHz, CHLOROFORM-D) d 8.05 (d, J = 1.7 Hz, 1H), 7.96 (dd, J = 7.9, 1.8 Hz, 1H), 7.45 (d, J = 7.8 Hz, 1H), 4.65-4.67 (m, 4H), 3.93-3.94 (m, 3H). |
With N-Bromosuccinimide;2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 10h;Reflux; | 3,4-Dimethyl-benzoic acid methyl ester (10 g), N-bromosuccinimide (23.6 g) and AIBN (1.0 g) are heated in CCl4 (118 mL) 10 h at reflux temperature. After cooling and filtration, the mixture is evaporated and the residue is treated with CHCl3 (ca. 200 mL) and an aqueous, saturated NaHCO3-solution. After separation of the organic phase, drying and evaporation, the residue is crystallized from methanol. 8.7 g of the title compound are obtained with MP 74-75 C. | |
With N-Bromosuccinimide;benzyl peroxide; In dichloromethane; at 25 - 120℃; | A catalytic amount of benzyl peroxide and NBS (82.9 g; 2 equiv.) was added to a solution of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong> (38.2 g; 1 equiv.) in 458.4 ml of dichloromethane. The resulting reaction mixture was stirred for 15 minutes at room temperature and then heated for 18 hours at reflux (110-120 C.). The reaction mixture was cooled to room temperature, filtered and concentrated under reduced pressure. The residue was taken up in dichloromethane, washed with 5% sodium carbonate solution, dried over sodium sulfate and again concentrated under reduced pressure. The methyl 3,4-bis(bromomethyl)benzoate so obtained (73.9 g) was used in the next stage without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-Bromosuccinimide; sodium bicarbonate; (E)-3,3'-(diazene-1,2-diyl)bis(2-methylpropanenitrile); triethylamine; In tetrachloromethane; toluene; | a) Methyl 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxylate A mixture of 77.0 g (0.469 Mol) of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong>, 178.0 g (1.0 Mol) of N-bromosuccinimide, 0.5 g of azoisobutyronitrile and 800 ml of tetrachloromethane was refluxed for 1 hour whilst simultaneously being subjected to intensive illumination with a 1000-Watt daylight bulb. The mixture was allowed to cool to about 40C, then filtered and the filter residue was washed thoroughly with 200 ml of tetrachloromethane. Within about 30 minutes, at a reaction temperature of +30C, a mixture of 53.6 g (0.575 Mol) of benzenemethanamine, 101.2 g (1.0 Mol) of triethylamine and 150 ml of toluene was added to the combined filtrates. The resulting mixture was refluxed for 3 hours, then left overnight at ambient temperature and filtered to remove the precipitate formed. The filtrate was freed from the solvent in vacuo , the residue remaining was distributed between tert.butyl-methylether and 20% aqueous citric acid, then the aqueous phase was extracted thoroughly with tert.butyl-methylether and ethyl acetate. Batches of sodium hydrogen carbonate were added to the aqueous phase until the development of carbon dioxide ceased, then the mixture was exhaustively extracted with a tert.butyl-methylether/ethyl acetate mixture (1:1 v/v). The combined extracts were worked up in the usual way and yielded 48.1 g (38% of theory) of colourless crystals, Mp. 72C. IR (CH2Cl2): 1735 (Carboxylate-C=O) cm-1 | |
With N-Bromosuccinimide; sodium bicarbonate; (E)-3,3'-(diazene-1,2-diyl)bis(2-methylpropanenitrile); triethylamine; In tetrachloromethane; toluene; | a Methyl 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxylate A mixture of 77.0 g (0.469 Mol) of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong>, 178.0 g (1.0 Mol) of N-bromosuccinimide, 0.5 g of azoisobutyronitrile and 800 ml of tetrachloromethane was refluxed for 1 hour whilst simultaneously being subjected to intensive illumination with a 1000-Watt daylight bulb. The mixture was allowed to cool to about 40 C., then filtered and the filter residue was washed thoroughly with 200 ml of tetrachloromethane. Within about 30 minutes, at a reaction temperature of +30 C., a mixture of 53.6 g (0.575 Mol) of benzenemethanamine, 101.2 g (1.0 Mol) of triethylamine and 150 ml of toluene was added to the combined filtrates. The resulting mixture was refluxed for 3 hours, then left overnight at ambient temperature and filtered to remove the precipitate formed. The filtrate was freed from the solvent in vacuo, the residue remaining was distributed between tert.butyl-methyl-ether and 20% aqueous citric acid, then the aqueous phase was extracted thoroughly with tert.butyl-methylether and ethyl acetate. Batches of sodium hydrogen carbonate were added to the aqueous phase until the development of carbon dioxide ceased, then the mixture was exhaustively extracted with a tert.butyl-methylether/ethyl acetate mixture (1:1 v/v). The combined extracts were worked up in the usual way and yielded 48.1 g (38% of theory) of colourless crystals, Mp. 72 C. IR (CH2 Cl2): 1735 (Carboxylate-C=O) cm-1 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; | SYNTHETIC EXAMPLE 10 Synthesis of 6-methoxycarbonyl-2,3-dicyanonaphthalene To a solution of 33.8 g (0.2 mol) of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong> and 142.2 g (0.8 mol) of N-bromosuccinimide in 500 ml of carbon tetrachloride was added 1 g of benzoyl peroxide, and the resulting mixture was irradiated by a 100-W high pressure mercury arc lamp for 8 to 12 hours under reflux in an irradiating tube. After cooling, the white crystals precipitated were removed by suction filtration and the carbon tetrachloride solution, i.e., the mother liquor was concentrated under reduced pressure. The solid thus obtained was recrystallized from hexane/methylene chloride to obtain 79 g of methyl 3,4-bis(dibromomethyl)benzoate as colorless crystals. Physical properties of methyl 3,4-bis(dibromomethyl)benzoate were as follows: | |
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; | EXAMPLE 1 [Synthesis of 6-methoxycarbonyl-2,3-dicyanonaphthalene] To a solution of 33.8 g (0.2 mol) of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong> and 142.4 g (0.8 mol) of N-bromosuccinimide in 500 ml of carbon tetrachloride was added 1 g of benzoyl peroxide, and the resulting mixture was irradiated from a 100-W high pressure mercury arc lamp for 8 to 12 hours under reflux. After the mixture was allowed to cool, the white crystals precipitated were removed by filtration and the carbon tetrachloride solution, i.e., the mother liquor was concentrated under reduced pressure. The solid thus obtained was recrystallized from hexane/methylene chloride to obtain 79 g of methyl 3,4-bis(dibromomethyl)benzoate in the form of colorless crystals. Physical properties of methyl 3,4-bis(dibromomethyl)benzoate were as follows: | |
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; | Synthesis Example 2 Synthesis of 6-methoxycarbonyl-2,3-dicyanonaphthalene 1 g of benzoyl peroxide was added to a solution of 33.8 g (0.2 mol) of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong> and 142.4 g (0.88 mol) of N-bromosuccinimide dissolved in 500 ml of carbon tetrachloride. The mixture was refluxed for 8 to 12 hours under light irradiation by a high pressure mercury lamp (100 W). After cooling, the resulting white crystal precipitated was removed by filtration. The filtrate was concentrated under reduced pressure to remove carbon tetrachloride. The resulting solid was recrystallized from hexane/methylene chloride to obtain 79 g of methyl 3,4-bis(dibromomethyl)benzoate as a colorless crystal. This methyl 3,4-bis(dibromomethyl)benzoate has the following properties. |
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; | Synthetic Example 14 [Synthesis of 6-methoxycarbonyl-2,3-dicyanonaphthalene] To a solution of 33.8 g (0.2 mol) of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong> and 142.2 g (0.8 mol) of N-bromosuccinimide in 500 ml of carbon tetrachloride was added 1 g of benzoyl peroxide, and the resulting mixture was irradiated by a 100-W high pressure mercury arc lamp for 8 to 12 hours under reflux. After cooling, the white crystals precipitated were removed by filtration and the carbon tetrachloride solution, i.e., the mother liquor was concentrated under reduced pressure. The solid thus obtained was recrystallized from hexane/methylene chloride to obtain 79 g of methyl 3,4-bis(dibromomethyl)benzoate as colorless crystals. Physical properties of methyl 3,4-bis(dibromomethyl)benzoate were as follows: |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With sulfuric acid; In methanol; water; | Production Example 7 Synthesis of Methyl 3,4-Dimethylbenzoate <strong>[619-04-5]3,4-Dimethylbenzoic acid</strong> (64.4 g, 429 mmol) was dissolved in methanol (600 ml), and sulfuric acid (9 ml) was added, which was followed by reflux under heating for 5 hours. The reaction mixture was concentrated to 160 ml and water was added. The mixture was extracted with ethyl acetate, and the organic extract was washed successively with water, 10% aqueous sodium hydroxide solution and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give 68.0 g of methyl 3,4-dimethylbenzoate (yield 97%). |
With thionyl chloride; In methanol; N,N-dimethyl-formamide; | (1) 15.0 g of <strong>[619-04-5]3,4-dimethyl benzoic acid</strong>, 29.0 ml of thionyl chloride, 100 ml of methanol, and 1 ml of DMF were processed in a similar manner as in Reference Example 14-(1) to give 15.7 g of methyl 3,4-dimethylbenzoate. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-Bromosuccinimide; dibenzoyl peroxide; | (2) 18.1 g of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong>, 39.2 g of N-bromosuccinimide, 200 mg of benzoyl peroxide, and 200 ml of carbontetrachloride were processed in a similar manner as in Reference Example 6-(1) to give a mixture containing methyl 3,4-bis-(bromomethyl)benzoate as a major component. (3) The procedure of Reference Example 14-(3) was followed using the whole mixture prepared above, 11.8 g of benzylamine, and 22.9 g of triethylamine to give 16.0 g of 2-benzyl-5-methoxycarbonylisoindoline. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium methylate; In 5,5-dimethyl-1,3-cyclohexadiene; | EXAMPLE 8 Preparation Of Benzoyl m-Methylbenzoylmethane Acetophenone (30 grams; 0.25 mol) methyl m-methyltoluate (136 grams; 1.0 mol), xylene (300 ml) and sodium methoxide (17.3 grams; 0.3 mol) were placed into a four-necked round bottom one liter flask equipped as in Example 1. The mixture was heated with stirring to 135-140 C. and maintained there for 6 hours under a blanket of nitrogen. The procedure set forth in Example 1 was used to recover the desired product, benzoyl m-methylbenzoylmethane (48 grams; 90% weight percent yield). | |
With sodium methylate; In 5,5-dimethyl-1,3-cyclohexadiene; | Example 8 Preparation Of Benzoyl m-Methylbenzoylmethane Acetophenone (30 grams; 0.25 mol) methyl m-methyltoluate (136 grams; 1.0 mol), xylene (300 ml) and sodium methoxide (17.3 grams; 0.3 mol) were placed into a four-necked round bottom one liter flask equipped as in Example 1. The mixture was heated with stirring to 135-140oC and maintained there for 6 hours under a blanket of nitrogen. The procedure set forth in Example 1 was used to recover the desired product, benzoyl m-methylbenzoylmethane (48 grams; 90% weight percent yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
SYNTHESIS EXAMPLE 1 [Synthesis of methyl 3,4-dimethylbenzoate] To 200 ml of methanol was added 47.6 g (0.317 mol) of 3,4-dimethylbenzoic acid, and the resulting mixture was refluxed for about 4 hours in the presence of about 6 ml of concentrated sulfuric acid with continuous extraction of water by use of Molecular Sieves 3A (a drying agent mfd. by Wako Pure Chemical Industries, Ltd.). After the mixture was allowed to cool, about 600 ml of water was added and the resulting mixture was extracted three times with about 200 ml of benzene. The benzene solution thus obtained was washed three times with a saturated aqueous sodium hydrogencarbonate solution and then three times with water, and subsequently dried by addition of anhydrous sodium sulfate. The benzene solution was concentrated and then distilled under reduced pressure to obtain 49.4 g of a colorless liquid at a boiling point of 133-134 C./30 mm Hg. This liquid was identified as methyl 3,4-dimethylbenzoate from the following analysis results: |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; sulfuric acid; water; benzene; | Synthesis Example 1 Synthesis of methyl 3,4-dimethylbenzoate 47.6 g (0.317 mol) of 3,4-dimethylbenzoic acid was added to 200 ml of methanol. The resulting mixture was refluxed in the presence of about 6 ml of concentrated sulfuric acid for about 4 hours with continuous extraction of water by using Molecular Sieves 3A (a desiccant manufactured by Wako Pure Chemical Industries, Ltd.). After cooling, about 600 ml of water was added thereto. The whole mixture was extracted with about 200 ml of benzene three times. The benzene solution was washed with a saturated aqueous sodium hydrogencarbonate solution three times and then with water three times. Thereto was added anhydrous sodium sulfate to dry the benzene solution. The dried benzene solution was concentrated and then subjected to distillation under reduced pressure to obtain 49.4 g of a colorless liquid having a boiling point of 133 - 134C at 30 mmHg. The following analytical results confirmed that the liquid was methyl 3,4-dimethylbenzoate. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A mixture of <strong>[38404-42-1]methyl 3,4-dimethylbenzoate</strong> (1.334 g, 8.13 mmol), N-bromosuccinimide (3.173 g, 17.83 mmol) and benzoyl peroxide (0.143 g, 0.592 mmol) in carbon tetrachloride (5 mL) was heated at reflux for 1.5 hours. Upon cooling to room temperature, the solids present were removed by vacuum filtration and the resulting solution concentrated in vacuo. The residue obtained was re-dissolved in THF (30 mL). To the solution was added triethylamine (2.265 mL, 16.25 mmol) and a solution of 4- methoxy benzylamine (1.05 mL, 8.13 mmol) in THF (20 mL). The resulting reaction mixture was stirred overnight at room temperature. The precipitate was removed via filtration and the solution obtained was concentrated in vacuo. The residue obtained was purified via flash chromatography (15-30% EtOAc/hexane) to afford a light yellow oil (1.185g). LCMS: (FA) ES+ 298; 1H ΝMR (CDC13, 400 MHz) £7.89 (dd, J = 7.8, 1.5Hz, IH), 7.84 (s, IH), 8.74 (d, / = 8.7 Hz, 2H), 7.313 (d, J = 8.7Hz 2H), 7.22 (d, J = 7.2Hz, 2H), 6.89 (d, J = 8.7Hz, 2H), 3.93 (s, 4H), 3.89 (s, 3H) , 3.85 (s, 2H), 3.82 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With Au#Co; oxygen; potassium carbonate; at 80℃; under 750.075 Torr; for 12h;Autoclave; | 20 mg of Au-Co composite particle load (0.1 mol%), 13.8 mg K2CO3 (10 mol%), 136 mg<strong>[6966-10-5]3,4-dimethylbenzyl alcohol</strong>(lmmol),4 mL of methanol was sequentially added to an autoclave with a 25 mL glass lining.After the oxygen is replaced three times, the pressure is increased to 0.1 MPa.The reaction was carried out at 80 C for 12 h, cooled to room temperature, and slowly degassed and depressurized.The catalyst is filtered, the filtrate is concentrated by rotary evaporation, and the residue column is chromatographed to obtain a colorless liquid product.Methyl 3,4-dimethylbenzoate 154.9 mg, yield 94%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | General procedure: To a 250 mL Erlenmeyer flask was added the benzaldehyde, 1a-g, (7.0 mmol), sodium iodide(2.1 g, 14.0 mmol) and an alcohol, 2a-b, (30 mL). The mixture was stirred until the solidsdissolved, and then stirred in an ice-water bath for ten minutes. Commercial household bleach(either 22 mL of a 5.25% solution, or 15 mL of an 8% solution, which was titrated with standardsodium thiosulfate solution to determine the actual concentration of sodium hypochlorite, 14mmol) was added dropwise over 20 minutes to the cooled reaction mixture: the solution turnedbrown with the addition of bleach. The ice bath was removed, and the reaction mixture wasstirred for one hour. Enough sodium thiosulfate solution (either 5% or 10%) was added todischarge the iodine color. The solution was diluted with 100 ml of water, and allowed to standin an ice bath until precipitation of the solid product was complete. The solid was filtered bysuction, washed with water, and allowed to dry. In those cases where the product did not solidify upon cooling, the reaction mixture wasextracted with dichloromethane (2 × 25 mL). The combined dichloromethane extracts werewashed with water and saturated sodium chloride solution, dried over sodium sulfate, and thesolvent removed under reduced pressure. For product mixtures, the integrations of the aldehydeprotons and the ester O-CH2 or O-CH protons were used to obtain the product ratios. If iodoformwas present in a mixture, it was quantitated by its distinctive NMR signal at 4.90 ppm in CDCl3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
18% | With methanol; sodium;Reflux; | General procedure: To 10 mL of absolute methanol was added 10 mmol of sodium and then 4-methylpiperazin-1-yl biguanidine x 2HCl (5 mmol) [19] and the appropriate carboxylic acid ester (5 mmol). The reaction mixture was refluxed for 15-30 h and 10 mL of water was added and stirred in the room temperature for 0.5 h. The precipitate was separated and crystallized from methanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With tert.-butylhydroperoxide; cetyltrimethylammonim bromide; potassium bromide; In water; at 120℃; under 750.075 Torr;Microwave irradiation; | General procedure: The reaction mixture was treated in a controlled microwavesynthesizer (Biotage Initiator+SP Wave model, 0-200 W at2.45 GHz, capped at 60 W during steady state) for severalminutes (the reaction attained 120 C at 1 bar pressure). Thefinal products were isolated by column chromatographyusing an EtOAc-hexane gradient |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
18% | NaH (0.40 g, 0.017 mol) was stirred in DMSO (10 mL) at 0 C under 9.1 mmol) in 5 mL DMSO and 3,4-Dimethylacetophenone (1.48 g, 10.0mol) in 5 mL DMSO through a syringe. The reaction mixture was stirredat room temperature for 1 h and then at 30 C for 1 h. After the reactionwas finished, the reaction mixture was poured into cooled aqueous HClsolution slowly and extracted by ethyl acetate. The organic phase wasdried over anhydrous Na2SO4 and the solvent was removed by evaporationunder vacuum to provide a pale yellow solid. The solid was thendissolved in chloroform (15 mL) under nitrogen, followed by addition ofBF3Et2O (2.29 mL, 18.2 mmol) drop by drop through a syringe. Then,the reaction mixture was allowed to stir at room temperature overnightand then quenched by water. The mixture was extracted by dichloromethaneand dried over anhydrous Na2SO4. The obtained crude productwas then subjected to column chromatography to provide a white solid(18%).1H NMR (400 MHz, CDCl3): δ7.93 (s, 2H), 7.88 (dd, J 8.0, 1.7 Hz,2H), 7.30 (d, J 8.0 Hz, 2H), 7.12 (s, 1H), 2.37 (d, J 4.0 Hz, 12H). 13CNMR (100 MHz, CDCl3): δ145.44, 137.75, 130.38, 129.85, 126.60,92.65, 20.36, 19.80. HRMS: calcd for C19H19BF2O2 [MH] 329.1522,found 329.1522. |
Tags: 38404-42-1 synthesis path| 38404-42-1 SDS| 38404-42-1 COA| 38404-42-1 purity| 38404-42-1 application| 38404-42-1 NMR| 38404-42-1 COA| 38404-42-1 structure
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P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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