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Chemical Structure| 3846-71-7 Chemical Structure| 3846-71-7

Structure of 3846-71-7

Chemical Structure| 3846-71-7

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Product Details of [ 3846-71-7 ]

CAS No. :3846-71-7
Formula : C20H25N3O
M.W : 323.43
SMILES Code : OC1=C(C(C)(C)C)C=C(C(C)(C)C)C=C1N2N=C(C=CC=C3)C3=N2
MDL No. :MFCD01075688
InChI Key :LHPPDQUVECZQSW-UHFFFAOYSA-N
Pubchem ID :77455

Safety of [ 3846-71-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 3846-71-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3846-71-7 ]

[ 3846-71-7 ] Synthesis Path-Downstream   1~32

  • 2
  • [ 52184-14-2 ]
  • [ 84755-44-2 ]
  • [ 3846-71-7 ]
  • 4
  • [ 84755-44-2 ]
  • [ 3846-71-7 ]
YieldReaction ConditionsOperation in experiment
73.3% aluminum nickel; In water; hydrogen; toluene; EXAMPLE 13 33.9 (0.1 mol) of 2-(2'-hydroxy-3',5'-di-t-butylphenyl)benzotriazole-N-oxide, 100 ml of toluene, 100 ml of isopropyl alcohol (IPA), 100 ml of water, 8.3 g of caustic soda and 5 g of Raney nickel were charged into a 500-ml stainless autoclave equipped with an agitator. After the air in the autoclave had been replaced by hydrogen, the pressure of hydrogen was set to 10 kg/cm2. The temperature of the resultant mixture was increased under agitation to 95 C. at which the mixture was then subjected to reaction for 12 hours until the absorption of hydrogen was stopped. After the reaction had been completed, after treatment was performed in the same way as that in Example 12 to obtain 23.7 g of 2-(2'-hydroxy-3',5'-di-t-butylphenyl)benzotriazole (yield, 73.3%; melting point, 150 to 152 C.).
71% With dimethyl amine;palladium-carbon; In hydrogen; EXAMPLE 3 10 g (0.03 mol) of 2-(2'-hydroxy-3',5'-di-t-butylphenyl)benzotriazole-N-oxide, 100 mg of palladium carbon, 100 ml of a solvent mixture comprising toluene and water (ratio by volume, 4:1) and 3 g of 50% dimethylamine were charged into a 500-ml autoclave equipped with an agitator. After the air in the autoclave had been replaced by hydrogen, the pressure of hydrogen was set to 10 kg/cm2. The temperature was increased to 50 C. under agitation, and reaction was effected at the same temperature while agitation being continued until no more hydrogen was absorbed by the mixture. After the reaction had been completed, the autoclave was cooled, and the catalyst was filtered off. When part of the filtrate was subjected to quantitative analysis using GC, it was found that the yield of 2-(2'-hydroxy-3',5'-di-t-butylphenyl)benzotriazole is 85.6%. After the solvent had been distilled off from the filtrate, the residual solid was crystallized by ethanol and then washed with ethanol to obtain 7.1 g of 2-(2'-hydroxy-3',5'-di-t-butylphenyl)benzotriazole (yield, 71%; melting point, 152 to 155 C.).
  • 5
  • [ 3864-99-1 ]
  • [ 3846-71-7 ]
  • 6
  • [ 3846-71-7 ]
  • [ 10096-91-0 ]
  • 7
  • [ 3846-71-7 ]
  • [ 3147-76-0 ]
  • [ 34074-96-9 ]
  • [ 10096-91-0 ]
  • 8
  • 2-Nitro-2'-hydroxy-3',5'-di-tert-butyl-azobenzene [ No CAS ]
  • [ 3846-71-7 ]
YieldReaction ConditionsOperation in experiment
77% In palladium on charcoal catalyst; triethylamine; isopropyl alcohol; EXAMPLE 9 2-(2-Hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole When using the general procedure of Example 5, a 23percent by weight suspension of 2-nitro-2'-hydroxy-3',5'-di-tert-butylazobenzene in isopropanol/triethylamine (1/0.18) was hydrogenated at 45° C. at 1 atmosphere pressure for 3 hours in the presence of 3percent of a 5percent palladium on charcoal catalyst the above noted product was obtained in a yield of 77percent.
73% palladium-carbon; In water; hydrogen; toluene; EXAMPLE 3 35.5 g (0.1 mol) of 2-nitro-2'-hydroxy-3',5'-di-t-butylazobenzene, 0.125 g of 5percent palladium carbon, 100 ml of toluene, 100 ml of IPA, 100 ml water and 8.3 g of caustic soda were charged into a 500-ml stainless autoclave equipped with an agitator. After the air in the autoclave had been replaced by hydrogen, the pressure of hydrogen was set to 10 kg/cm2. Reaction was effected in the same way as that employed in Example 1. After the reaction had been completed, the catalyst was filtered off. When part of the filtrate was subjected to quantitative analysis using GC, it was found that the yield of 2-(2'-hydroxy-3',5'-di-t-butylphenyl)benzotriazole is 82percent. After the solvent had been distilled off from the filtrate, the residual solid was crystallized by IPA, washed with IPA and then dried to obtain 23.6 g of 2-(2'-hydroxy-3',5'-di-t-butylphenyl)benzotriazole (yield, 73percent; melting point, 150°to 152° C.).
70% EXAMPLE 10 2-Nitro-2'-hydroxy-3',5'-di-tert.-butyl-azobenzene is reacted, according to Example 8, to give 2-(2'-hydroxy-3',5'-di-tert.-butyl-phenyl)-benzotriazole in a yield of 70percent of theory.
aluminum nickel; In triethylamine; isopropyl alcohol; EXAMPLE 17 2-(2-Hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole When using the general procedure of Example 1, a 22percent by weight suspension of 2-nitro-2'-hydroxy-3',5'-di-tert-butylazobenzene in isopropanol/triethylamine (1/0.18) was hydrogenated at 45° C. in the presence of a Raney nickel catalyst (6percent by weight based on the azobenzene intermediate) for a period of 13 hours, the above named compound was obtained in a 67percent yield. When the amount of catalyst above was increased to 20percent by weight based on the azobenzene, the hydrogenation was completed in 1.1 hour at 45° C. to give a 75percent yield of product.

  • 9
  • [ 52184-14-2 ]
  • [ 1643-39-6 ]
  • [ 95-54-5 ]
  • [ 3846-71-7 ]
  • 11
  • [ 3846-71-7 ]
  • [ 784163-33-3 ]
YieldReaction ConditionsOperation in experiment
5.1% With hydrogen bromide; bromine; In 1,1-dichloroethane; water; acetic acid; acetone; Example 1 2,4-Di-tert-butyl-6-(4,7-dibromo-benzotriazol-2-yl)-phenol Benzotriazol-2-yl-4,6-di-tert-butyl-phenol (48.6 g, 0.15 mol) was placed in a 3-neck 1-L flask equipped with a stir bar, an addition funnel, a reflux condenser, and a flow control adapter. Through a three-way connecting tube the nitrogen flow was diverted to the flask via the condenser and to an oil bubbler. The bubbler was connected to a filtration flask containing aqueous sodium hydroxide. Hydrobromic acid (45percent in acetic acid, 300 mL) was added. The system was purged with nitrogen for 15 min. The slurry was heated to 110° C. for 0.5 h and bromine (23.2 mL, 0.45 mol, 3 equivalent) was added dropwise. The addition was completed in 1 h and the mixture was stirred for an additional 1 h. Three more portions of bromine (3*23.2 mL, 3*0.45 mol) were added and stirring continued for one more hour. The flask was cooled to room temperature. Water (200 mL) was added and the mixture was filtered. The solid was collected and dissolved in dichloroethane (0.5 L). The solution was neutralized first with NaOH (aq) and then with NaHCO3 (aq). The organic layer was dried over magnesium sulfate. The drying agent was filtered off. The solvent of the filtrate was removed by rotary evaporation resulting in a viscous oil. Upon addition of acetone (200 mL) yellow crystalline solid was produced. The product was purified by recrystallization from acetone. Purity: 99+percent. Yield: 5.1percent. Melting point 244-246° C.
  • 12
  • [ 52184-29-9 ]
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  • 14
  • [ 84755-45-3 ]
  • [ 3846-71-7 ]
  • 15
  • [ 88-74-4 ]
  • 3-nitro-aniline; 4-nitro-aniline [ No CAS ]
  • [ 3846-71-7 ]
  • 16
  • [ 89-63-4 ]
  • [ 3846-71-7 ]
YieldReaction ConditionsOperation in experiment
92% Example 18 Preparation of 2-(2-hydroxy-3-5-di-tert-butylphenyl)-2H-benzotriazole The same process as in Example 3 was carried out except that 2-nitro-2-hydroxy-3-5-di-tert-butylazobenzene (89percent) was used as a starting material. The result was that the yield of 2-(2-hydroxy-3-5-di-tert-butylphenyl)-2H-benzotriazole was 92percent of theoretical yield.
90% EXAMPLE 22 2-(2'-hydroxy-3',5'-di-tert.-butylphenyl)-2H-benzotriazole Example 1 is repeated, except that an equivalent amount of 2-nitro-2'-hydroxy-3', 5'-di-tert.-butylazobenzene (91percent pure) is used instead of 2-nitro-2'-hydroxy-5'-methylazobenzene and a mixture of 40 g of xylene and 60 g of diethylenetriamine instead of 80 g of xylene and 20 g of diethylenetriamine. The hydrogenation is carried out at 50° C. After work up of the hydrogenation solution, the product is crystallized from a mixture of 40 g of xylene and 160 g of methanol. The product (title compound) is isolated in a yield of 90percent of theory. Melting point: 152°-154° C.
85.8% EXAMPLE 18 2-(2-Hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole Using the general procedure 6, 35.5 grams of 2-nitro-2'-hydroxy-3',5'-di-tert-butylazobenzene was suspended in 100 grams of tributyl phosphate, 50 grams of methanol and 4 grams of sodium hydroxide. To the suspension was then added 8 grams of Raney nickel catalyst and hydrogenation was carried out under 1 atmosphere of hydrogen at 45° C. for 7 hours. The catalyst was separated by filtration at 80° C. The above named product was obtained in the usual manner in a yield of 85.8percent.
49.2% EXAMPLE 14 2-(2-Hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole When using the procedure of Example 4, the 2-nitro-2'-hydroxy-5'-methylazobenzene was replaced by an equivalent amount of 2-nitro-2'-hydroxy-3,5-di-tert-butylazobenzene and using a total of 4 grams of molybdenum-promoted Raney nickel catalyst, the above named product was obtained in a yield of 49.2percent.
Example 19 The same process as in Example 18 was carried out except that the sequence of addition of sulfuric acid and zinc powder in the second reduction was reversed. The result was that almost the same yield of 2-(2-hydroxy-3-5-di-tert-butylphenyl)-2H-benzotriazole as that of Example 18 was attained.
Examples of the 2-(2'-hydroxyphenyl)benzotriazoles of group q) are 2-(2'-hydroxy-5'-methylphenyl)benzotriazole,2-(3',5'-di-tert-butyl-2'-hydroxyphenyl)benzotriazole,2-(5'-tert-butyl-2'-hydroxyphenyl)benzotriazole,2-(2'-hydroxy-5'-(1,1,3,3-tetramethylbutyl)phenyl)benzotriazole,2-(31,5'-di-tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole,2-(3'-tert-butyl-2'-hydroxy-5'-methylphenyl)-5-chlorobenzotriazole,2-(3'-sec-butyl-5'-tert-butyl-2'-hydroxyphenyl)benzotriazole,2-(2'-hydroxy-4'-octyloxyphenyl)benzotriazole,2-(3',5'-di-tert-amyl-2'-hydroxyphenyl)benzotriazole,
Illustrative of the corresponding benzotriazole compounds that can be made from the 2-(2-nitrophenylazo) substituted phenols prepared by the present process are:...(28) 5-chloro-2-(2-hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole;(29) 2-(2-hydroxy-5-methylphenyl)-2H-benzotriazole;(30) 5-fluoro-2-(2-hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole;(31) 5-bromo-2-(2-hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole;(32) 2-(2-hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole;(33) 5-chloro-2-(2-hydroxy-3,5-di-alpha-cumylphenyl)-2H-benzotriazole;(34) 5-fluoro-2-(2-hydroxy-3,5-di-alpha-cumylphenyl)-2H-benzotriazole;(35) 5-chloro-2-(2-hydroxy-3-alpha-cumyl-5-tert-octylphenyl)-2H-benzotriazole;...
2.1 Derivatives of 2-(2'-Hydroxyphenyl)benzotriazoles Such as, for Example:2-(2'-hydroxy-5'-methylphenyl)benzotriazole;2-(3',5'-di-t-butyl-2'-hydroxyphenyl)benzotriazole;2-(5'-t-butyl-2'-hydroxyphenyl)benzotriazole;[2-(2'-hydroxy-5'-(1,1,3,3-tetramethylbutyl)phenyl]benzotriazole;2-(3',5'-di-t-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole;2-(3'-t-butyl-2'-hydroxy-5'-methylphenyl)-5-chlorobenzotriazole;2-(3'-sec-butyl-5'-t-butyl-2'-hydroxyphenyl)benzotriazole;2-(2'-hydroxy-4'-octyloxyphenyl)-benzotriazole;2-(3',5'-di-t-amyl-2'-hydroxyphenyl)-benzotriazole;...
2.1 Derivatives of 2-(2'-hydroxyphenyl)benzotriazoles such as, for example:2-(2'-hydroxy-5'methylphenyl)benzotriazole;2-(3',5'-di-t-butyl-2'-hydroxyphenyl)benzotriazole;2-(5'-t-butyl-2'-hydroxyphenyl)benzotriazole;2-[2'-hydroxy-5'-(1,1,3,3-tetramethylbutyl)phenyl]benzotriazole;2-(3',5'-di-t-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole;2-(3'-t-butyl-2'-hydroxy-5'-methylphenyl)-5-chlorobenzotriazole;2-(3'-sec-butyl-5'-t-butyl-2'-hydroxyphenyl)benzotriazole;2-(2'-hydroxy-4'-octyloxyphenyl)-benzotriazole;2-(3',5'-di-t-amyl-2'-hydroxyphenyl)-benzotriazole;...
For the benzotriazole compounds of the formulae (7) and (8), the following may be mentioned by way of example:...2-(2'-hydroxy-3'-acryloylamidomethyl-5'-methylphenyl)benzotriazole,2-(2'-hydroxy-3'-acryloylamidomethyl-5'-benzylphenyl)benzotriazole,2-(2'-hydroxy-3'-butoxacetamidomethyl-5'-benzylphenyl)benzotriazole,2-(2'-hydroxy-3'5'-di-tert-amylphenyl)benzotriazole, and2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole.
As examples of the benzotriazole-type ultraviolet absorber, the following can be mentioned but should not be considered limiting:2-(2-hydroxy-5-methylphenyl)benzotriazol,2-[2-hydroxy-3-(3,4,5,6-tetrahydrophthalimidomethyl)-5-methylphenyl]benzotriazol,2-(3-t-butyl-2-hydroxy-5-methylphenyl)-5-chlorobenzotriazol,2-(3,5-di-t-butyl-2-hydroxyphenyl)-5-chlorobenzotriazol,2-(3,5-di-t-butyl-2-hydroxyphenyl)benzotriazol,2-(3,5-di-t-amyl-2-hydroxyphenyl)benzotriazol,2-(2-hydroxyphenyl-5-t-octylphenyl)benzotriazol,2-[2-hydroxy-3,5-bis(alpha,alpha-dimethylbenzyl)phenyl]-2H-benzotriazol2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol],...
Examples of the ultraviolet absorber include the following:...2-(2-hydroxy-5-methylphenyl)benzotriazole,2-[2-hydroxy-3-(3,4,5,6-tetrahydrophthalimidemethyl)-5-methylphenyl]benzotriazole,2-(3-t-butyl-2-hydroxy-5-methylphenyl)-5-chlorobenzotriazole,2-(2-hydroxy-5-t-octylphenyl)benzotriazole,2-(3,5-di-t-butyl-2-hydroxyphenyl)benzotriazole,2-(3,5-di-t-amyl-2-hydroxyphenyl)benzotriazole,2-(3,5-di-t-butyl-2-hydroxyphenyl)-5-chlorobenzotriazole,2-2-hydroxy-3,5-bis(alpha,[alpha-dimethylbenzyl)phenyl]-2H-benzotriazole,...
14.8 g (91.5%) (b) 2-(2-hydroxy-3,5-di-t-butylphenyl)benzotriazole Yield: 14.8 g (91.5percent), Melting Point: 150° to 152° C.
Examples of stabiliser systems are:...2-hydroxy-4-octooxybenzophenone and1-lauroylamino-2,2,6,6-tetramethyl-1-aza-4-thiacyclohexane-4,4-dioxide,2-(2-hydroxy-5-methylphenyl)-benzotriazole and1-lauroylamino-2,2,6,6-tetramethyl-1-aza-4-thiacyclohexane-4,4-dioxide,2-(2-hydroxy-3,5-di-tert.butylphenyl)-benzotriazole and1-lauroylamino-2,2,6,6-tetramethyl-1-aza-4-thiacyclohexane-4,4-dioxide,2-(2-hydroxy-3-tert.butyl-5-methylphenyl)-5-chlorobenzotriazole and1-lauroylamino-2,2,6,6-tetramethyl-1-aza-4-thiacyclohexane-4,4-dioxide,...
For instance, suitable UV absorbers are selected from the group consisting of3-(2H-benzotriazol-2-yl)-4-hydroxy-5-(1-methylpropyl)-benzenesulfonic acid monosodium salt;2-(2-hydroxy-3,5-di-tert-butylphenyl)-2H-benzotriazole;2-(2-hydroxy-3,5-di-tert-amylphenyl)-2H-benzotriazole;4,6-bis(2,4-dimethylphenyl)-2-(4-(3-dodecyloxy*-2-hydroxypropoxy)-2-hydroxyphenyl)-s-triazine (*is mixture of C12-14oxy isomers);12-hydroxy-3,6,9-trioxadodecyl 3-tert-butyl-4-hydroxy-5-(2H-benzotriazol-2-yl)-hydrocinnamate;2,4-dihydroxybenzophenone;2,2'-dihydroxy-4,4'-dimethoxy-5,5'-disulfobenzophenone, disodium salt;2,2',4,4'-tetrahydroxybenzophenone;3-(4-benzoyl-3-hydroxyphenoxy)-2-hydroxy-N,N,N-trimethyl-1-propanaminium chloride;...

  • 18
  • [ 592-34-7 ]
  • [ 3846-71-7 ]
  • 2-[2-(butoxycarbonyloxy)-3,5-di(tert-butyl)-phenyl]-benzotriazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; tetra(n-butyl)ammonium hydrogen sulfate; In water; toluene; Example D - Esterification with acid chlorides by phase-transfer catalysis 0 1 mol of 2-[2-hydroxy-3,5-di(tert-butyl)-phenyl]-benzotriazole is dissolved in 150-200 ml of toluene. To the solution are added 20 g of NaOH dissolved in 20 ml of water (50percent NaOH solution) and 0.01 mol of tetrabutylammonium hydrogen sulfate (PTC). There is immediately formed an orange-coloured emulsion, and this is heated to 40° C. At this temperature is slowly added dropwise a solution of 0.11 mol of chloroformic acid butyl ester in about 30 ml of toluene. The reaction proceeds exothermically, and from 45°-50° C. it is cooled with ice-water. At the end of the dropwise addition, the reaction solution has become light-yellow. Stirring is maintained for a further 2 hours, after which time no further starting product can be identified in the thin-layer chromatogram. The reaction solution is cooled to room temperature, and about 200 ml of water are added. The organic phase is then separated and is washed twice with 100 ml of water each time. The toluene solution is dried with sodium sulfate and is afterwards concentrated in a rotary evaporator. The light-yellow residue is recrystallized from ethanol to thus obtain 2-[2-(butoxycarbonyloxy)-3,5-di(tert-butyl)-phenyl]-benzotriazole (compound No. 39) in the form of white crystals which melt at 116°-118° C. By variation of the acid chloride, there are obtained in an analogous manner the following phenolic esters: STR13
  • 19
  • [ 37859-25-9 ]
  • [ 3846-71-7 ]
  • 2-[2-(1-naphthylacetoxy)-3,5-di(tert-butyl)-phenyl]-benzotriazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; Example C - Esterification with acid chloride 0.12 mol of triethylamine is added to a solution of 0.08 mol of 2-[2-hydroxy-3,5-di(tert-butyl)-phenyl]-benzotriazole in 150 ml of methylene chloride. To this solution is slowly added dropwise at 10°-15° C., with stirring, a solution of 0.08 mol of 2-naphthylacetyl chloride in 50 ml of methylene chloride. The temperature is then allowed to rise to 20°-25° C., and the mixture is stirred for 6 hours at this temperature. The triethylammonium chloride which has precipitated is filtered off, and the filtrate is washed with water, dried over Na2 SO4 and concentrated by evaporation. The crystalline, reddish-coloured residue is recrystallized from hexane to thus obtain 2-[2-(1-naphthylacetoxy)-3,5-di(tert-butyl)-phenyl]-benzotriazole in the form of white crystals which melt at 150°-151° C. (compound No. 25). There are obtained in an analogous manner the following phenol esters of the general formula STR8
  • 20
  • 2-Nitro-2'-hydroxy-3',5'-di-tert-butyl-azobenzene [ No CAS ]
  • [ 130-15-4 ]
  • [ 3846-71-7 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; sodium; sodium hydrogensulfite; In water; isopropyl alcohol; EXAMPLE 2 A suspension of 9.2 g of sodium in 400 g of isopropanol is refluxed in a 1.5 liter sulfonating flask until a solution is formed. To this are added, at 60° C., 3.2 g of 1,4-naphthoquinone, 2.1 g of sodium bisulfite and 71 g of 2-nitro-2'-hydroxy-3',5'-bis-tert.-butylazobenzene. The mixture is stirred at 60° C. for between half an hour and a full hour. 20 g of 17 percent by volume aqueous sulfuric acid and 100 ml of warm water at 60°-70° C. are then added dropwise. The precipitated crystals are filtered and are washed with warm 60 percent by weight aqueous methanol and with warm water. Drying at 70°-80° C. n vacuo produces 2,4-di-tert.-butyl-6-(2'-benzotriazolyl)-phenol in a high yield.
With sodium hydroxide; sulfuric acid; sodium hydrogensulfite; In water; isopropyl alcohol; EXAMPLE 5 200 g of isopropanol are heated to 60° C. in a 750 ml sulfonating flask, and 1 g of sodium bisulfite, 1.6 g of 1,4-naphthoquinone, 14 g of sodium hydroxide and 35.5 g of 2-nitro-2'-hydroxy-3',5'-bis-tert.-butylazobenzene are then added. The mixture is stirred at 75°-80° C. for two hours, and 18 g of 17 percent by volume aqueous sulfuric acid and 50 ml of warm water are then added dropwise. The precipitated crystals are washed with warm methanol and then with warm water. The product is a high yield of 2,4-di-tert.-butyl-6-(2'-benzotriazolyl)-phenol.
  • 21
  • [ 117-80-6 ]
  • 2-Nitro-2'-hydroxy-3',5'-di-tert-butyl-azobenzene [ No CAS ]
  • [ 3846-71-7 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In cyclohexanol; EXAMPLE 4 A 750 ml sulfonating flask is charged with 300 g of cyclohexanol, 35.5 g of 2-nitro-2'-hydroxy-3',5'-bis-tert.-butylazobenzene, 2.3 g of 2,3-dichloronaphthoquinone and 25.6 g of sodium hydroxide. The mixture is stirred at 70°-75° C. for three hours and is brought to pH 1.5 with 5 percent by volume aqueous hydrochloric acid. The aqueous phase is separated off and discarded. The organic phase is washed with water and cooled down to -5° C. A high yield of 2,4-di-tert.-butyl-6-(2'-benzotriazolyl)-phenol crystallises out.
  • 22
  • [Cu5(2,4,6-Me3C6H2)5] [ No CAS ]
  • [ 121-46-0 ]
  • [ 3846-71-7 ]
  • [ 194808-57-6 ]
  • 23
  • [ 75-24-1 ]
  • [ 3846-71-7 ]
  • [ 1268704-20-6 ]
  • 24
  • [ 546-68-9 ]
  • [ 3846-71-7 ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenolate)2Ti(OiPr)2] [ No CAS ]
  • 25
  • [ 6046-93-1 ]
  • [ 3846-71-7 ]
  • [ 1472068-54-4 ]
  • 26
  • [ 14314-61-5 ]
  • [ 3846-71-7 ]
  • [aluminium(III)(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butyl-phenolato)2(NMe2)] [ No CAS ]
  • 27
  • [ 1070655-38-7 ]
  • [ 3846-71-7 ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol)2Hf(OiPr)2] [ No CAS ]
  • 28
  • [ 14717-56-7 ]
  • [ 3846-71-7 ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol)2(-H)Zr(OiPr)2] [ No CAS ]
  • 29
  • [ 19756-04-8 ]
  • [ 3846-71-7 ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol)2(-H)2Zr(NMe2)2] [ No CAS ]
  • 30
  • [ 19756-04-8 ]
  • [ 3846-71-7 ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol)2(-H)4Zr] [ No CAS ]
  • 31
  • [ 110-54-3 ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol)2(-H)2Zr(NMe2)2] [ No CAS ]
  • [ 3846-71-7 ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol)2(-H)4Zr] [ No CAS ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol)2(-H)3Zr(NMe2)] [ No CAS ]
  • 32
  • [ 1070655-38-7 ]
  • [ 3846-71-7 ]
  • [(2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol)2Hf(OiPr)2] [ No CAS ]
 

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Chemical Structure| 78299-75-9

A317708 [78299-75-9]

5-(Benzyloxy)-1H-indazole

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Chemical Structure| 850364-08-8

A153638 [850364-08-8]

4-(Benzyloxy)-1H-indazole

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Chemical Structure| 1175793-77-7

A132639 [1175793-77-7]

3-(m-Tolyl)-1H-indazol-5-amine

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Alcohols

Chemical Structure| 1131595-36-2

A183446 [1131595-36-2]

3-Methyl-1H-indazol-7-ol

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Chemical Structure| 81382-46-9

A133183 [81382-46-9]

1H-Indazol-7-ol

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Chemical Structure| 201286-99-9

A357250 [201286-99-9]

6-Hydroxy-3-methylindazole

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Chemical Structure| 15579-15-4

A732478 [15579-15-4]

1H-Indazol-5-ol

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Chemical Structure| 769069-96-7

A220517 [769069-96-7]

(3-(2-Aminophenyl)-1H-pyrazol-5-yl)methanol

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Related Parent Nucleus of
[ 3846-71-7 ]

Other Aromatic Heterocycles

Chemical Structure| 3325-11-9

A103032 [3325-11-9]

1H-Benzo[d][1,2,3]triazol-5-amine

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Chemical Structure| 1293284-50-0

A199074 [1293284-50-0]

4-Fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

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Chemical Structure| 1072249-89-8

A287628 [1072249-89-8]

3-Methyl-1H-pyrazolo[3,4-c]pyridine

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Chemical Structure| 1033772-26-7

A151507 [1033772-26-7]

Methyl 1H-pyrazolo[3,4-c]pyridine-5-carboxylate

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Chemical Structure| 1207557-36-5

A186108 [1207557-36-5]

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine

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