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Chemical Structure| 387350-79-0 Chemical Structure| 387350-79-0

Structure of 387350-79-0

Chemical Structure| 387350-79-0

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Product Details of [ 387350-79-0 ]

CAS No. :387350-79-0
Formula : C15H19F3N2O2S
M.W : 348.38
SMILES Code : O=S(C1=CC=CC(C(F)(F)F)=C1)(N(C2CC2)C3CCNCC3)=O
MDL No. :MFCD01568000

Safety of [ 387350-79-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P271-P261-P280

Application In Synthesis of [ 387350-79-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 387350-79-0 ]

[ 387350-79-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 387350-79-0 ]
  • [ 138165-75-0 ]
  • [ 884308-88-7 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; To a solution of N-cyclopropyl-N-(piperidin-4-yl)-3-trifluoromethylbenzenesulfonamide (0.287 mmol, 100 mg) in DMF (5 mL) was added HOBt (0.287 mmol, 39 mg), EDCI (0.287 mmol, 55 mg) and BOC-L-b-homoleucine (0.287 mmol, 70 mg) at room temperature. The resulting mixture was kept shaken at room temperature overnight. EtOAc (20 mL) was then added to the mixture and the mixture was washed with 10% HCl (20 mL), saturated NaHCO3 (20 mL) and water (10 mL). The organic layer was dried over Na2SO4 and concentrated to dryness. The crude product was purified through a column of silica gel with a gradient of 25% to 100% EtOAc in hexanes to afford (3S) 1-{4-[cyclopropyl-(3-trifluoromethylbenzenesulfonyl)amino]piperidine-1-ethanoyl}-3-methylbutyl carbamic acid tert-butyl ester (45).
  • 2
  • [ 387350-79-0 ]
  • [ 4481-28-1 ]
  • C23H24F3N3O4S [ No CAS ]
 

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