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CAS No. : | 38806-09-6 | MDL No. : | MFCD11226171 |
Formula : | C7H10O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | JXBAKCMWFYJKGF-UHFFFAOYSA-N |
M.W : | 142.15 | Pubchem ID : | 10214400 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 0.71 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 34.87 |
TPSA : | 43.37 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.95 cm/s |
Log Po/w (iLOGP) : | 1.83 |
Log Po/w (XLOGP3) : | 0.31 |
Log Po/w (WLOGP) : | 0.47 |
Log Po/w (MLOGP) : | 0.25 |
Log Po/w (SILICOS-IT) : | 1.24 |
Consensus Log Po/w : | 0.82 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -0.72 |
Solubility : | 27.2 mg/ml ; 0.191 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.78 |
Solubility : | 23.4 mg/ml ; 0.165 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -1.09 |
Solubility : | 11.7 mg/ml ; 0.082 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.3 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridinium p-toluenesulfonate; In toluene; for 20h;Reflux; Dean-Stark; | Methyl 1-acetylcyclopropanecarboxylate (5.02 g,35.3 mmol, 1 equiv) and pyridinium-paratoluenesulfonate (1.36 g,5.30mmol, 0.15 equiv) were dissolved in 150 ml of toluene. Ethylene glycol (7.80 ml, 141 mmol, 4.00 equiv) was added and the reaction was stirred at reflux with a Dean-Starck apparatus for 20 h until no more water was formed. Toluene and ethylene glycol were removed by distillation. The reaction was concentrated then dissolved with 45 ml of ethanol. 2 M NaOH aqueous solution (45.0 ml, 90.0 mmol, 2.50 equiv) was added and the reactionwas stirred at 25 C for 19 h to give a yellow suspension. The reaction was saturated with NaCl and acidified with 6 N HCl to reach a persistent pH 4. The mixture was extracted with 350 ml of DCM. Combined organic layers were dried over MgSO4, and concentrated. The crude was purified by flash chromatography over silica gel, petroleum ether/EtOAc (95/5 to 20/80) to give 4.35 g of a white solid (71%). 1H NMR (300MHz, CDCl3) dH1.03e1.06 (2H, m, CH2eCH2), 1.21e1.26 (2H, m, CH2eCH2), 1.57 (3H,s, CH3eCOO), 3.93e4.04 (4H, m, OeCH2eCH2eO). 13C NMR(75.47 MHz, CDCl3) dC 13.6 (CH2, CH2eCH2), 24.1 (CH3, CeCH3), 30.4(C, COOeCeCOOH), 65.3 (CH2, OeCH2eCH2eO),108.1 (C, COO),178.1(C, COOH). IR (KBr) n: 3431 (br.), 1689, 1050 cm1. m/z HR-MS: (DCI/CH4): calculated for C8H13O4 173.0814, found 173.0818. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With tetrabutylammomium bromide; potassium carbonate; In acetonitrile; for 96h; | 1-Acetylcyclopropanecarboxylic acid methyl ester (28)To a vigorously stirred suspension of anhydrous K2 CO3 (40.0 g; 290 mmol) in acetonitrile (100 ml), tetra-n-butylammonium bromide (3.20 g; 10.0 mmol), 1,2-dibromoethane (13.0 ml; 28.4 g; 150 mmol) and methyl acetoacetate 27 (10.8 ml; 11.6 g; 100 mmol) were added. The reaction mixture was stirred for 4 days. The solids were filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by distillation under reduced pressure to give 9.55 g (67.0 mmol; 67% yield) of 28. 1H NMR (400 MHz, CDCl3) δ 1.48 (4H, s), 2.47 (3H, s), 3.75 (3H, s); 13C NMR (101 MHz, CDCl3) δ 19.3, 29.8, 34.9, 171.5, 203.0; MS (EI) m/z 143 ([M+H]+, 100), 142 (M+, 70), 127 (81), 111 (87); exact mass calculated for C7H11O3 ([M+H]+) 143.0708. found 143.0705. |
67% | K2CO3 (11.9 g, 86.0 mmol, 2.50 equiv) was suspended in 35 ml of acetone. Methylacetoacetate (3.70 ml, 34.4 mmol, 1.00 equiv) was added dropwise to the suspension. The mixture was stirred at room temperature for 20 min. 1,2-Dibromoethane (6.00 ml, 68.9 mmol, 2.00 equiv) was added and the reaction was stirred at reflux for 26 h. The reaction was filtered and concentrated. The crude mixture was purified by flash chromatography, using petroleum ether/EtOAc (95/5 to 90/10) to give 3.26 g (67% yield) of a colorless oil. Rf (petroleum ether/EtOAc:90/10) 0.50. 1H NMR (300 MHz, CDCl3) dH 1.47 (4H, s,CH2eCH2), 2.46 (3H, s, COeCH3), 3.74 (3H, s, COOCH3). | |
52% | With potassium carbonate; In acetone; for 36h;Reflux; | To a mixture of methyl 3-oxobutanoate (10 g, 86 mmol), potassium carbonate (29.8 g, 36 mmol) and acetone (150 mL) was added 1,2-dibromoethane (21 g, 112 mmol) and the mixture was heated under reflux for 1.5 days. The reaction mixture was cooled to room temperature, insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography [eluent: hexane-ethyl acetate (97:3-3:1)] to give the title compound (6.41 g) as a colorless oil (yield 52%). 1H NMR (300 MHz, CDCl3) δ 1.48 (4H, s), 2.47 (3H,s), 3.75 (3H,s). |
37% | With potassium hydroxide; In hexane; dimethyl sulfoxide; | a) Methyl 1-Acetylcyclopropylcarboxylate Methyl acetoacetate (8.6ml, 80mmol), 1,2-dibromoethane (7ml, 80mmol) and potassium hydroxide (11.2g, 200mmol) in DMSO (80ml) were stirred for 48h, poured into water, acidified and extracted with ether (3x50ml). The extracts were washed with water (2x100ml) and brine 50ml), dried, concentrated and flash chromatographed on silica gel eluding with 5-10% ethyl acetate in hexane to yield the title compound (4.18g, 37%); δH(90MHz, CDCl3) 1.46 (4H,s), 2.44 (3H,s), 3.72 (3H,s). |
With potassium carbonate; In acetone; at 20℃; for 8h;Heating / reflux; | Reference Example 87 To a mixture of methyl acetoacetate (10.0 g), potassium carbonate (29.8 g), and acetone (145 mL) was added 1,2-dibromoethane (21.0 g) at room temperature, and the mixture was heated under reflux for 8 hours. The reactant was concentrated after cooling to room temperature. The obtained residue was purified by silica gel column chromatography to obtain methyl 1-acetylcyclopropanecarboxylate (1.90 g). 1H-NMR (300 MHz, CDCl3) δ: 1.49 (4H, s), 2.47 (3H, s), 3.75 (3H, s). | |
2.17 g | With potassium carbonate; In acetone; at 65℃; for 17h; | To a solution of methyl acetoacetate (3 ml) in acetone (30 ml) were sequentially added potassium carbonate (11.54 g) and 1,2-dibromoethane (2.4 ml) at room temperature, and the mixture was stirred at 65 C. for 17 hours. This reaction mixture was filtered, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=10/1) to give the titled compound (2.17 g). 1H-NMR (CDCl3) δ: 1.48 (s, 4H), 2.47 (s, 3H), 3.75 (s, 3H). |
0.7 mol | With potassium carbonate; In acetone; at 70℃; for 24h; | Step a. To a solution of methyl acetoacetate (1.72 mol) and 1,2-dibromoethane (1.90 mol) in acetone (2000 ml) was added K2CO3 (2.59 mol) at rt. The reaction mixture was heated at 70C for 24 h. The resulting reaction mixture was allowed to cool to rt and filtered through celite hyflow. The celite cake was washed with acetone (2 x 100 ml). The filtrate was concentrated under reduced pressure and the resulting residue was purified by column chromatography (4% EtOAc in hexane) yielding methyl 1-acetylcyclopropane-l-carboxylate (0.70 mol). MS: ES+ 143.14. |
100 g | With potassium carbonate; In acetone; at 70℃; for 24h; | To a solution of methyl acetoacetate (200 g, 1724.13 mmol) and 1 ,2- dibromoethane (179.2 mL, 2068.95 mmol) in acetone (2000 mL) was added K2CO3 (356.8 g, 2586.19 mmol) at rt. The reaction mixture was heated at 70C for 24 h. The resulting mixture was cooled to rt, filtered through celite and washed with acetone (2 x 100 mL). The filtrate was concentrated under reduced pressure to give a crude oil which was purified by column chromatography (4% EtOAc in hexane) to yield methyl 1 -acetylcyclopropane-1 -carboxylate (100 g, 704.22 mmol). LCMS: Method C, 1 .47 min, MS: ES+ 143.14 |
100 g | With potassium carbonate; In acetone; at 70℃; for 24h; | To a solution of methyl acetoacetate (200 g, 1724.13 mmol) and 1,2-dibromoethane (179.2 mL, 2068.95 mmol) in acetone (2000 mL) was added K2C03 (356.8 g, 2586.19 mmol) at rt. The reaction mixture was heated at 70C for 24 h. The resulting mixture was cooled to rt, fdtered through celite and washed with acetone (2 x 100 mL). The filtrate was concentrated under reduced pressure to give a crude oil which was purified by column chromatography (4% EtOAc in hexane) to yield methyl 1-acetylcyclopropane-l-carboxylate (100 g, 704.22 mmol). LCMS: Method C, 1.47 min, MS: ES+ 143.14. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; potassium iodide; potassium carbonate; In N,N-dimethyl acetamide; | Example 2 Production of Methyl 1-Acetyl-1-cyclopropanecarboxylate A total of 662.4 g of potassium carbonate, 1161.2 g of 1,2-dichloroethane, 696.7 g of N,N-dimethylacetamide, 33.2 g of potassium iodide, and 464.5 g of methyl acetoacetate were mixed, followed by a reaction at 100 C. for 13 hours. The reaction mixture was cooled to room temperature and was filtrated, the resulting filtrate was washed with two portions of 5% by weight hydrochloric acid, and the organic layer was washed with water. The washing with the aqueous layer was extracted with 999.7 g of 1,2-dichloroethane. The extract with the organic layer was concentrated under a reduced pressure to distill off 1,2-dichloroethane, was subjected to distillation under a reduced pressure and thereby yielded 160.1 g of methyl 1-acetyl-1-cyclopropanecarboxylate as a colorless liquid as a fraction at 75 C./20 mmHg. [Spectral data] 1H-NMR (CDCl3) δ: 1.48 (s, 4H, cyclopropane), 2.48 (s, 3H, C3COC), 3.75 (s, 3H, CH3O) | |
With β‐cyclodextrin; sodium hydroxide; at 40 - 45℃; for 3h; | 1st: To 2L reaction flask, methyl acetoacetate 1a (116.1g, 1.0 µM), dichloroethane (247.4g, 2.5 eq) and β-cyclodextrin (22.7g, 0.02 eq) were heated, stirred to 40 C, slowly added 40% sodium hydroxide solution (400.0g, 4.0 eq), time consuming 1.0h drops, and stirred 40-45 C at 2.0h C. dropwise.After stopping heating to room temperature, the alkali liquor layer containing β-cyclodextrin is separated for recycling, the dichloroethane layer is separated, water is added for washing to neutral and directly used for ring opening halogenation reaction, and intermediate (2a) gas chromatography purity 97% (de-dichloroethane). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With n-butyllithium; ammonium chloride; oxalic acid; In tetrahydrofuran; hexane; diisopropylamine; | 6.) (5E,7E,22E)-(1S,3R)-1,3-Bis[[dimethyl(1,1dimethylethyl)silyl]oxy]-24-oxo-26,27-cyclo-9,10-secocholesta-5,7,10(19),22-tetraene-25-carboxylic acid 6 38.8 ml of butyllithium (1.6 molar in hexane) is instilled with ice cooling under nitrogen in 9.5 ml of diisopropylamine in 607 ml of tetrahydrofuran and stirred for 15 minutes. Then 8.83 g of 1-acetylcyclopropane carboxylic acid methyl ester (D. F. Taber et al., J. Org. Chem. (1992) 57, 436) is instilled at -78 C. and stirred for 1 hour. Then 5.96 g of aldehyde 1 (Calverly, Tetrahedron 43 4609 (1987)) in 18.4 ml of tetrahydrofuran is instilled at -78 C. and stirred for 1.5 hours. Then the reaction mixture is allowed to reach 0 C. within 1.5 hours and it is stirred for 15 minutes more at this temperature. After addition of saturated ammonium chloride solution at -20 C. it is diluted with saturated sodium chloride solution at room temperature, extracted with ethyl acetate by addition of 5% oxalic acid, dried on sodium sulfate and concentrated by evaporation. The thus obtained crude product (11.90 g of yellow oil) is subjected to the subsequent esterification without further purification. An NMR-sample is obtained after thin layer chromatographic (silica gel, ethyl acetate/hexane) purification. 1 H-NMR(300 MHZ, CDCl3): δ=0.05 ppm (s, 12H); 0.57 (s, 3H); 0.84 (s, 9H); 0.87 (s, 9H); 1.10(d, J=7 Hz, 3H); 1.73 (m, 2H); 2.03 (m, 2H); 4.23 (m, 1H); 4.53 (m, 1H); 4.94 (br. s, 1H); 4.97 (br. s, 1H); 5.82 (d, J=11 Hz, 1H); 5.85 (d, J=15 Hz, 1H); 6.43 (d, J=11 Hz, 1H); 7.13 (dd, J=15 Hz, J=9 Hz, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of <strong>[38806-09-6]methyl 1-acetylcyclopropanecarboxylate</strong> (1.66 g, 11.68 mmol) obtained in Example 194-A) in methanol (18 mL) was added 8M aqueous sodium hydroxide solution (2.92 mL, 23.35 mmol), and the mixture was stirred at room temperature for one day. The mixture was neutralized with Dowex 50W-X8 (H+ form), the resin was filtered off, and washed with methanol. The filtrate was concentrated under reduced pressure to give a colorless oil (1.03 g) containing the title compound. This was used in the next step without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
20% | 1-Acetylcyclopropanethiocarboxylic acid S-n-butyl ester (29)To a stirred solution of 28 (6.80 g; 47.9 mmol) in methanol (40 ml) LiOHxH2O (1.05 g; 25.0 mmol) was added. After 3 days, 1M HCl solution in diethyl ether (25.0 ml; 25.0 mmol) was added dropwise at 0 C. Solvents were removed under reduced pressure and residual moisture was removed by evaporating with anhydrous toluene (3×30 ml). The residue was dissolved in anhydrous methylene chloride (140 ml) and treated with N-hydroxysuccinimide (5.52 g; 48.0 mmol), 4-dimethylaminopyridine (293 mg; 2.40 mmol) and N,N'-dicyclohexylcarbodiimide (12.4 g; 60.0 mmol) for 6 hours. Then triethylamine (1.35 ml; 0.97 g; 9.60 mmol) and 1-butanethiol (25.6 ml; 21.6 g; 240 mmol) was added. After 2 days, volatiles were removed under reduced pressure and the residue was purified by column chromatography (2-8% ethyl acetate/hexane) to give 1.95 g (9.75 mmol; 20% yield) of 29. 1H NMR (400 MHz, CDCl3) δ 0.93 (3H, t, J=7.3 Hz), 1.40 (2H, m), 1.51 (4H, m), 1.56 (2H, m), 2.37 (3H, s), 2.91 (2H, t, J=7.4 Hz); 13C NMR (101 MHz, CDCl3) δ 13.5, 18.8, 21.9, 28.9, 29.0, 31.3, 43.8, 197.0, 202.5; MS (EI) m/z 201 ([M+H]+, 15), 200 (M+, 5), 173 (17), 145 (30), 116 (54), 111 (100); exact mass (ESI) calculated for C10H16O2SNa ([M+Na]+) 223.0769. found 223.0764. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
4.36 g | Under argon atmosphere, to a solution of diisopropylamine (2.37 ml) in tetrahydrofuran (11 ml) was added n-butyllithium (10.4 ml, 1.6M solution in n-hexane) at 0 C., and the mixture was stirred for 0.5 hours. At -78 C., a solution of 1-accetylcyclopropane carboxylic acid methyl ester (2.17 g) in tetrahydrofuran (11 ml) was added thereto, and the mixture was stirred for 0.5 hours. Then, N-phenylbis(trifluoromethanesulfonimide) (6.00 g) was added thereto, and the mixture was stirred for 0.5 hours, and then stirred at 0 C. for additional 1 hour. To this reaction mixture was added water, and the mixture was extracted with ethyl acetate. This organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure to give the titled compound (4.36 g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1.46 g | With bromine; In ethanol; at 20℃; for 2.25h;Cooling with ice; | Methyl 1-acetylcyclopropanecarboxylate (ref. Synthetic Communications, 26, 535-530, 1996) (1.090 g, 7.68 mmol) in EtOH (3.5 mL), cooled with an ice bath, was treated with bromine (1.59 g, 10 mmol) dropwise over 15 min, under stirring. The reaction was allowed to reach rt and after 2 h was treated with water (6 mL). The solvent was evaporated and the aqueous phase was extracted with EtOAc (20 mL). The organic phase was washed with 10% sodium thiosulfate (2 mL), saturated aqueous NaHC03 and brine, dried over feSC and evaporated to leave 1.46 g of methyl 1-(bromoacetyl)cyclopropanecarboxylate which was employed in the following step without any further purification.HRMS (ESI+): calcd. for C7H10BrO3[M + H]+220.9808; found 220.9810. |
Tags: 38806-09-6 synthesis path| 38806-09-6 SDS| 38806-09-6 COA| 38806-09-6 purity| 38806-09-6 application| 38806-09-6 NMR| 38806-09-6 COA| 38806-09-6 structure
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P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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