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Chemical Structure| 39714-33-5 Chemical Structure| 39714-33-5

Structure of 39714-33-5

Chemical Structure| 39714-33-5

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Product Details of [ 39714-33-5 ]

CAS No. :39714-33-5
Formula : C6H5Cl2N3O
M.W : 206.03
SMILES Code : O=C(NC)C1C(Cl)=NC(Cl)=NC=1
MDL No. :N/A

Safety of [ 39714-33-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 39714-33-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 39714-33-5 ]

[ 39714-33-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 74-89-5 ]
  • [ 2972-52-3 ]
  • [ 39714-33-5 ]
YieldReaction ConditionsOperation in experiment
33% With triethylamine; In tetrahydrofuran; dichloromethane; at -78℃; for 1h; Step-1. Preparation of 2,4-dichloro-N-methylpyrimidine-5-carboxamide (2): To a solution of methyl amine (2M) in THF (2.4 mL, 4.70 mmol) in DCM (50 ml), TEA (963 mg, 9.50 mmol) and <strong>[2972-52-3]2,4-dichloropyrimidine-5-carbonyl chloride</strong> (1 g, 4.70 mmol) were added slowly at -78 C. for 1 h. TLC showed completion of starting material (TLC system: 10% ethyl acetate in hexane (Rf): 0.3). The reaction mixture was diluted with DCM (50 ml), washed with water (2*30 ml) and a saturated solution of NaHCO3. The organic layer was separated, dried over sodium sulphate, and concentrated. Crude compound was purified by column chromatography using silica gel (100-200 mesh) with 5% ethyl acetate in hexane to obtain 2,4-dichloro-N-methylpyrimidine-5-carboxamide as white solid. Yield: (400 mg, 33%). 1HNMR (400 MHz, CDCl3) δ 8.98 (s, 1H), 6.50 (br s, 1H), 3.07 (d, 3H, J=4.8 Hz).
 

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