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[ CAS No. 400858-39-1 ] {[proInfo.proName]}

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Chemical Structure| 400858-39-1
Chemical Structure| 400858-39-1
Structure of 400858-39-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 400858-39-1 ]

CAS No. :400858-39-1 MDL No. :
Formula : C18H24N2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 268.40 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 400858-39-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 400858-39-1 ]

[ 400858-39-1 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 400858-39-1 ]
  • [ 116854-10-5 ]
  • N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-5-methoxyindan-1-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 48 By the reaction and treatment in the same manner as in Example 12 using <strong>[116854-10-5]5-methoxyindan-1-carboxylic acid</strong> (0.50 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.80 g) as starting materials, N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-5-methoxyindan-1-carboxamide (1.00 g) was obtained. 1H-NMR(CDCl3)delta: 1.23(6H,d,J=6.9), 2.08-2.09(1H,m), 2.31-2.38(1H,m), 2.63-2.77(1H,m), 2.86-2.93(1H,m), 2.93(6H,s), 3.76(3H,s), 3.90(1H,t,J=8.6hz), 4.71(1H,d,J=13.9Hz), 4.92(1H,d,J=13.9Hz), 6.63-6.73(4H,m), 6.95-7.02(3H,m), 7.01(2H,d,J=8.7Hz), 7.17(2H,d,J=8.3Hz).
  • 2
  • [ 400858-39-1 ]
  • [ 1914-65-4 ]
  • N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In dichloromethane; 1,2-dichloro-ethane; Example 4 To a solution of 1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (3.3 g) in 1,2-dichloroethane (20 mL) was added thionyl chloride (2.1 mL), and the mixture was heated under reflux with stirring for 3 hr. The reaction mixture was concentrated under reduced pressure, and methylene chloride (10 mL) was added to the residue. This solution was added to a solution of [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (5.1 g) in methylene chloride (10 mL) under ice-cooling. The reaction mixture was warmed to room temperature and stirred at the same temperature for one day. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography. The obtained crystals were recrystallized from isopropyl ether to give N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (4.38 g). melting point: 121ØC
  • 3
  • [ 20426-80-6 ]
  • [ 400858-39-1 ]
  • N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)chroman-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 13 By the reaction and treatment in the same manner as in Example 1 using <strong>[20426-80-6]chroman-4-carboxylic acid</strong> (0.5 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.63 g) as starting materials, N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)chroman-4-carboxamide (0.25 g) was obtained. melting point: 110-112ØC
  • 4
  • [ 400858-39-1 ]
  • [ 80858-95-3 ]
  • N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 24 By the reaction and treatment in the same manner as in Example 12 using <strong>[80858-95-3]6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid</strong> (0.54 g) and [(4-dimethylaminophenyl)methyl](4-isopropylphenyl)amine (0.7 g) as starting materials, N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.36 g) was obtained. 1H-NMR(CDCl3)delta: 1.23(6H,d,J=6.6Hz), 1.35-1.55(1H,m), 1.75-2.10(3H,m), 2.55-2.70(1H,m), 2.75-3.00(2H,m), 2.94(6H,s), 3.60-3.70(1H,m), 3.74(3H,s), 4.70(1H,d,J=13.9Hz), 4.93(1H,d,J=13.9Hz), 6.50-6.75(4H,m), 6.90-7.20(7H,m).
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