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Chemical Structure| 4047-24-9 Chemical Structure| 4047-24-9

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Chemical Structure| 4047-24-9

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Product Details of [ 4047-24-9 ]

CAS No. :4047-24-9
Formula : C15H14O3
M.W : 242.27
SMILES Code : CC(C1=C(O)C=CC=C1OCC2=CC=CC=C2)=O
MDL No. :MFCD00100620

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Application In Synthesis of [ 4047-24-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4047-24-9 ]

[ 4047-24-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 3240-35-5 ]
  • [ 4047-24-9 ]
  • (E)-4-[3-(2-benzyloxy-6-hydroxyphenyl)-3-oxopropene-1-yl]benzenesulfonamide [ No CAS ]
  • 2
  • [ 4047-24-9 ]
  • [ 79636-94-5 ]
  • (E)-1-(2-(benzyloxy)-6-hydroxyphenyl)-3-(5-bromo-2-ethoxyphenyl)prop-2-en-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With potassium hydroxide; In methanol; at 85℃; for 3h; 5-Bromo-2-ethoxy-benzaldehyde 7a (473 mg, 2.06 mmol), 1-(2-benzyloxy-6-hydroxy-phenyl)-ethanone 6 (500 mg, 2.06 mmol),and MeOH (9 mL) were combined and KOH in methanol (40%weight/volume, 8.24 mL) added at room temperature. A water condenser was attached to the flask, and the orange solution quickly turned dark red upon heating and was stirred at reflux in an oilbath at 85 C for 3 h. Workup involved evaporation of the solvent and addition of 1 N HCl until the solution was at pH 1, followed by extraction with ethyl acetate (twice). The organic layer was separated,dried over anhydrous Na2SO4, filtered, and concentrated to give an orange solid. Column chromatography was performed (10%EtOAc:hexane) to purify the product. A crystallization step was then performed (ethyl acetate/hexane) to obtain the pure product(75% yield). 8o: mp 107-109 C, 1H NMR (CDCl3): d 13.08 (s,0.76H), 8.07 (d, 1H), 8.03 (d, 0.53H), 7.81 (d, 0.58H), 7.78 (d,0.47H), 7.41 (m, 2H), 7.37 (m, 2H), 7.33 (d, 1H), 7.29 (m, 3H),6.73 (d, 2H, J = 8.8 Hz), 6.66 (d, 1H, J = 1.2 Hz), 6.64 (d, 1H,J = 1 Hz), 6.55 (d, 1H, J = 1 Hz), 6.53 (d, 1H, J = 0.7 Hz), 5.14 (s,2H), 4.00 (1, 2H), 1.54 (s, 0.93H), 1.41 (t, 3H). 13C NMR (CDCl3): d165.05, 160.17, 157.1, 136.20, 133.87, 130.38, 128.76, 127.59,126.20, 113.68, 112.76, 102.71, 71.36, 64.31, 14.68; Anal.C24H21BrO4: C, H; HRMS for C24H22BrO4 (M+H): theory 453.0701;found 453.0691.
  • 3
  • [ 4047-24-9 ]
  • [ 79636-94-5 ]
  • 4-benzyloxy-2-(5-bromo-2-ethoxy-benzylidene)-benzofuran-3-one [ No CAS ]
 

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