Alternatived Products of [ 406233-35-0 ]
Product Details of [ 406233-35-0 ]
CAS No. : | 406233-35-0 |
MDL No. : | MFCD16251357 |
Formula : |
C18H24N4O4S2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
424.54
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 406233-35-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 406233-35-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 406233-35-0 ]
- 1
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[ 406233-26-9 ]
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[ 406233-35-0 ]
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(R)-4-(3-dimethylamino-1-phenylsulfanylmethylpropylamino)-N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-3-nitrobenzenesulfonamide
[ No CAS ]
- 2
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[ 162046-66-4 ]
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[ 406233-35-0 ]
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[ 926933-96-2 ]
- 3
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[ 6668-56-0 ]
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[ 406233-35-0 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 5 steps
1: 162.4 g / aq. NH3 / propan-2-ol / 0.5 h / -35 °C
2: 68 percent / DIPEA / dimethylformamide / 12 h / 20 °C
3: 99 percent / HCl / dioxane / 6 h / 20 °C
4: 56 percent / EDCI; DMAP / tetrahydrofuran; dimethylformamide / 16 h / 20 °C
5: 99 percent / BH3 / tetrahydrofuran / 16 h / 20 °C |
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Reference:
[1]Wendt, Michael D.; Shen, Wang; Kunzer, Aaron; McClellan, William J.; Bruncko, Milan; Oost, Thorsten K.; Ding, Hong; Joseph, Mary K.; Zhang, Haichao; Nimmer, Paul M.; Ng, Shi-Chung; Shoemaker, Alexander R.; Petros, Andrew M.; Oleksijew, Anatol; Marsh, Kennan; Bauch, Joy; Oltersdorf, Tilman; Belli, Barbara A.; Martineau, Darlene; Fesik, Stephen W.; Rosenberg, Saul H.; Elmore, Steven W.
[Journal of Medicinal Chemistry, 2006, vol. 49, # 3, p. 1165 - 1181]
- 4
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[ 406233-35-0 ]
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[ 1044598-91-5 ]
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[ 852811-25-7 ]
- 5
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[ 870812-32-1 ]
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[ 97-09-6 ]
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[ 406233-35-0 ]
Yield | Reaction Conditions | Operation in experiment |
74% |
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide for 24h; Inert atmosphere; Large scale; |
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Reference:
[1]Hardouin, Christophe; Baillard, Sandrine; Barière, François; Craquelin, Anthony; Grandjean, Mathieu; Janvier, Solenn; Le Roux, Stéphane; Penloup, Christine; Russo, Olivier
[Organic Process Research and Development, 2020, vol. 24, # 5, p. 670 - 685]