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Chemical Structure| 41220-34-2 Chemical Structure| 41220-34-2

Structure of 41220-34-2

Chemical Structure| 41220-34-2

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Product Details of [ 41220-34-2 ]

CAS No. :41220-34-2
Formula : C13H20N2
M.W : 204.31
SMILES Code : NC1CCN(CC2=CC=CC=C2C)CC1
MDL No. :MFCD09049748

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Application In Synthesis of [ 41220-34-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 41220-34-2 ]

[ 41220-34-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1643-16-9 ]
  • [ 41220-34-2 ]
  • C24H32N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; Preparation Example 1 Synthesis of Compound 1 (0191) (0192) A vial was charged with a carboxylic acid (330 mg, 1.1 equiv.), a solvent (1 mL of a solution of 200 g N-oxybenzotriazole in 1 L of DMF), and an amine (316 mg, 1 equiv.). To the stirred reaction mixture, EDC was added (290 mg, 1.21 equiv.). Incase the reaction mixture became highly viscous, some more DMF was added. In case the reaction mixture was a homogeneous solution, it was kept at room temperature for 72 hrs. Otherwise the reaction mixture was sonicated at room temperature for 5 days. The reaction mixture was diluted with 1% aqueous sodium phosphate solution until the vial was full. Then the vial was sonicated. In case a crystalline precipitate was formed, the vial was subjected to the filtration. In case an oily product was formed, the product was dissolved in methanol and precipitated by an addition of 4% hydrochloric acid. Alternatively 2-propanol (1 mL) was mixed with the crude product and the mixture was sonicated. Then the solution was diluted with 5% aqueous sodium hydrogen carbonate solution (the procedure repeated 2-3 times if necessary). The crude product was purified by chromatography (silica gel, chloroform:2-propanol=4:1). The yield was 425 mg (72%).
 

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