Alternatived Products of [ 41284-92-8 ]
Product Details of [ 41284-92-8 ]
CAS No. : | 41284-92-8 |
MDL No. : | N/A |
Formula : |
C8H5IO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
260.03
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Pubchem ID : | - |
Synonyms : |
|
Application In Synthesis of [ 41284-92-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 41284-92-8 ]
- 1
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[ 41284-92-8 ]
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Zn(CN)2
[ No CAS ]
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[ 82104-74-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
tetrakis(triphenylphosphine)palladium (0); In N,N-dimethyl-formamide; |
Example 4 A mixture of Zn(CN)2 (2.4 g, 0.02 mol) and 5-iodo-3H-isobenzofuran-1-one (5.24 g, 0.02 mol) in DMF (80 mL) were stirred at room temperature under an atmosphere of argon for 30 minutes. Then dissolved oxygen was removed by bubbling argon through the reaction mixture for 10 minutes before the addition of tetrakis(triphenylphosphine)palladium (0) (1.2 g, 0.00096 mol). Then the reaction was heated at 75° C. for 3 hrs, and then the solvent was removed under reduce pressure and the residue poured into water (150 mL). Filtration and followed by drying in vacuo give the crude 5-cyano-3H-isobenzofuran-1-one (2.4 g) (HPLC 93percent). |
- 2
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[ 41284-92-8 ]
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[ 1520-31-6 ]
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5-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-3H-isobenzofuran-1-one
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
80% |
With (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine In acetonitrile at 29℃; for 16h; Irradiation; chemoselective reaction; |
General Procedure
General procedure: Ir[dF(CF3)ppy]2(dtbpy))PF6(5.6 mg, 4.99 µmol) was added to a stirred solution of aryl iodide (1.00 mmol), iminodimethyl-λ6-sulfanone (102 mg, 1.10 mmol), 4,4'-di-tert-butyl-2,2'-bipyridine (20 mg, 0.07 mmol), TEA (0.279 mL, 2.00 mmol) and NiCl2(glyme) (11 mg, 0.05 mmol) in acetonitrile (5.6 mL). The resulting mixture was irradiated with a blue LED (450 nm, Penn Optical Photoreactor m1) and stirred at 29 °C for 16 hours. The reaction mixture was quenched with saturated aqueous NaHCO3(2 mL) and extracted with EtOAc. The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure.The resulting residue was purified by flash silica chromatography to afford the corresponding products. |