41602-56-6|4-(Dimethylamino)-2-hydroxybenzaldehyde| Ambeed

CAS No. :	41602-56-6
Formula :	C₉H₁₁NO₂
M.W :	165.19
SMILES Code :	CN(C)C1=CC(O)=C(C=O)C=C1
MDL No. :	MFCD00027419
InChI Key :	KURCTZNCAHYQOV-UHFFFAOYSA-N
Pubchem ID :	9815305

Safety of [ 41602-56-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Computational Chemistry of [ 41602-56-6 ] Show Less

Physicochemical Properties

Num. heavy atoms	12
Num. arom. heavy atoms	6
Fraction Csp3	0.22
Num. rotatable bonds	2
Num. H-bond acceptors	2.0
Num. H-bond donors	1.0
Molar Refractivity	48.06
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	40.54 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.39
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	1.02
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	1.27
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	0.83
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	1.07
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	1.12

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-1.74
Solubility	2.97 mg/ml ; 0.018 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-1.46
Solubility	5.71 mg/ml ; 0.0346 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-1.87
Solubility	2.21 mg/ml ; 0.0134 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.58 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	1.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.12

Application In Synthesis of [ 41602-56-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 41602-56-6 ]

[ 41602-56-6 ] Synthesis Path-Downstream 1~54

1
[ 41602-56-6 ]
[ 593-56-6 ]
4-dimethylamino-2-hydroxy-benzaldehyde-(O-methyl oxime ) [ No CAS ]

References: [1]Patent: US2712031,1953, .

2
[ 41602-56-6 ]
[ 79-19-6 ]
4-dimethylamino-2-hydroxy-benzaldehyde-thiosemicarbazone [ No CAS ]

References: [1]Journal of Pharmacy and Pharmacology,1950,vol. 2,p. 764,768.

3
[ 50-00-0 ]
[ 99-07-0 ]
[ 41602-56-6 ]

References: [1]Patent: DE105103, .

4
[ 79055-17-7 ]
[ 41602-56-6 ]
7-Dimethylamino-7',8'-dihydroxy-2'-oxo-2'H-[2,3']bichromenyl-1-ylium; perchlorate [ No CAS ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1983,vol. 325,p. 505 - 510.

5
[ 41602-56-6 ]
[ 74696-95-0 ]
7,7'-Bis-dimethylamino-2'-oxo-2'H-[2,3']bichromenyl-1-ylium; perchlorate [ No CAS ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1983,vol. 325,p. 505 - 510.

6
[ 41602-56-6 ]
[ 141-97-9 ]
7,7'-Bis-dimethylamino-2'-oxo-2'H-[2,3']bichromenyl-1-ylium; perchlorate [ No CAS ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1983,vol. 325,p. 505 - 510.

7
[ 63907-38-0 ]
[ 68-12-2 ]
[ 41602-56-6 ]
[ 96649-22-8 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2690 - 2698.

8
[ 68-12-2 ]
[ 99-07-0 ]
[ 41602-56-6 ]

Yield	Reaction Conditions	Operation in experiment
90.9%	With methanesulfonyl chloride; at 20 - 100℃; for 1h;	To 20-40 C, 13.8 g (0.1 mol) of N, N-dimethyl-m-hydroxyaniline, 16.0 g (0.22 mol) of N, N-(0.125 mol) of methylsulfonyl chloride was added dropwise to control the dropwise temperature of not more than 40 C, and the mixture was stirred for 1.0 hour and kept at a temperature of 50 to 100 C. After the reaction was completed, the temperature was lowered to 30 C , Add appropriate amount of water hydrolysis, filtration, a small amount of water, 4-N, N-dimethyl-2-hydroxybenzaldehyde 15.0g. Yield 90.9%, content 95.5%.
68%		The compound was prepared following the literature procedure with some modifications [24]. The Vilsmeier Haack adduct wasprepared by addition of POCl3 (15.0 mL, 0.16 mol) dropwise to dryDMF (30 mL) at 0 C, and the mixturewas then stirred for 30 min atthe same temperature. To the adduct, a solution of 3-(N,N-dimethylamino)phenol (11.0 g, 80.3 mmol) in dry DMF (23 mL) wasadded dropwise at 0 C. The reaction mixture was slowly warmedto room temperature, stirred for 4 h, and then heated at 85-90 Cfor 30 min. The reaction mixture was allowed to cool to roomtemperature and kept at that temperature with stirring overnight.It was then poured into crushed ice and neutralized with saturatedaqueous solution of Na2CO3 (120 mL). The precipitate was filteredoff, washed with water and dried in a vacuum oven at 25 C for 4 h.Yield: 9.00 g (68%), m.p. 78-79 C (lit. 80.5-81 C). The compoundwas used without further purification. 1H NMR (500 MHz, CDCl3)(Fig. S1-S3): delta=11.56 (1H, s, OH), 9.47 (1H, s, CHO), 7.24 (1H, d,J 9 Hz, H-6), 6.24 (1H, dd, J 9, 2.1 Hz, H-5), 6.03 (1H, d, J 2.1 Hz,H-3), 3.02 (6H, s, CH3); 13C NMR (125 MHz, CDCl3) (Fig. S4):delta= 192.4, 164.1, 156.2, 135.2, 111.7, 104.6, 97.2, 40.1. FT-IR:nCO 1628 cm-1.
65%	With trichlorophosphate; at 20 - 80℃; for 1.16667h;	3-N, N-dimethylaminophenol(10.5 g, 0.075 mol) was dissolved in 20 mL of dry DMF,(0.1 mL, 0.22 mol) in fresh Vilsmeier Haack reagent, followed by stirring at room temperature for 20 min,Heating to 40 reaction 20min, and then heated to 80 reaction 30min. Cooled to room temperature,The reaction mixture was quickly poured into a large amount of ice water, and the solution was neutralized with NaHCO3,The precipitate was collected and filtered, washed with water and dried to give 8.8 g of the desired product in 65% yield.

65%		3-N, N-dimethylaminophenol (10.5 g, 0.075 mol)Was dissolved in 20 mL of dry DMF,And added dropwise from phosphorus oxychloride (8.2 mL, 0.09 mol) and at room temperatureAnhydrous DMF (17 mL, 0.22 mol)In the new Vilsmeier Haack reagent,Followed by stirring at room temperature for 20 min,Heated to 40 reaction 20min,Then warmed to 80 reaction 30min.Cool to room temperature,The reaction mixture is quickly poured into a large amount of ice water,The above solution was neutralized with NaHCO3, the precipitate was collected and filtered, washed with water,After drying, 8.8 g of the target product was obtained in a yield of 65%.
	With trichlorophosphate; at 0 - 90℃; for 1.25h;Inert atmosphere;	General procedure: We performed the Vilsmeier-Haack reaction to add the aldehyde function to the 2-aminophenol derivative. The phosphoryl oxychloride POCl3 (1.2 equiv in 3.0 equiv of anhydrous DMF) was carefully added dropwise to the previous synthesis product (also in anhydrous DMF: 200 mul for 1 mmol) under argon at 0 C. The reaction mixture was stirred 15 min at 0 C, then 15 min at room temperature,15 min at 37 C and finally 30 min at 80-90 C. After cooling, addition of ice and Na2CO3 in the reaction mixture and stirring, we obtain a precipitate (not pure but the cyclisation selects the desired coumarinic end product). This reaction step was used for the compounds 18-22. The previously synthesized salicylaldehyde (1.0 equiv) was dissolved in EtOH (10 ml for 1 mmol). Meldrum acid (1.2 equiv) was added to the stirred solution. Piperidineand acetic acid were added dropwise to catalyse the reaction (six drops for 1 mmol). The solution was stirred and heated 3 h under reflux. After cooling, the yellow to orange precipitate was filtered and obtained pure. This final reaction step was used for all the compounds (the only synthesis step of 17 and 23).
	With trichlorophosphate; at 0 - 80℃;	4-(Dimethylamino)salicylaldehyde was prepared by the reported procedure [18] with little modification. To a dry DMF solution (21.0 ml) containing 3-(dimethylamino)phenol (3.10 g, 22.6 mmol) was added POCl3 (4.0 ml, 43.2mmol) at 0 C. The mixture was stirred for 10min, and further stirred for 30 min at room temperature. Then the resulting mixture was stirred overnight at 80 C. After cooling, the reaction mixture poured into ice-cold water. The solution was neutralized using saturated Na2CO3, and the formed precipitate was filtered off, washed several times with water and dried under vacuum. m.p. 80.1-81.2 C [19]; 1H NMR (400 MHz, CDCl3): delta 3.09 (s, 6H, CH3), 6.10-7.29 (m, 3H, Ar-H), 9.53 (s, 1H, OH), 11.61 (s, 1H, CHO).
3.30 g	With trichlorophosphate; at 0 - 80℃;	4-(Dimethylamino)salicylaldehydewas synthesized according to the literature [15,16] with littlemodification. POCl3 (4.0 mL, 43.2 mmol) was added dropwiseto dry DMF (21.0 mL, 271.8 mmol) containing 3-(dimethylamino)phenol (3.10 g, 22.6 mmol) at 0 C, and the mixture wasstirred for 10 min, slowly warmed to room temperature andstirred for another 30 min. The reaction mixture was heated at80 C overnight. After cooling to room temperature, the mixturewas poured into ice cold water. The solution was neutralizedwith saturated Na2CO3. The precipitate was washedseveral times with distilled water, and dried under vacuum to yield 3.30 g of 1. 1H NMR (400 MHz, CDCl3) delta 3.09 (s, 6H,CH3), 6.10-7.29 (m, 3H, Ar-H), 9.53 (s, 1H, OH), 11.61 (s, 1H,CHO). This was consistent with the literature.

References: [1]Chemistry - An Asian Journal,2010,vol. 5,p. 2053 - 2061.
[2]Patent: CN104262253,2017,B .Location in patent: Paragraph 0049; 0050; 0051; 0052.
[3]Molecules,2009,vol. 14,p. 4838 - 4848.
[4]Journal of Molecular Structure,2018,vol. 1154,p. 373 - 381.
[5]Chemical Papers,2010,vol. 64,p. 806 - 811.
[6]Chemical Communications,2019,vol. 55,p. 4703 - 4706.
[7]Journal of Chemical Sciences,2011,vol. 123,p. 459 - 466.
[8]Patent: CN106543126,2017,A .Location in patent: Paragraph 0026; 0027.
[9]Patent: CN106543125,2017,A .Location in patent: Paragraph 0020; 0026; 0027.
[10]Dyes and Pigments,2011,vol. 90,p. 56 - 64.
[11]Journal of the American Chemical Society,2013,vol. 135,p. 12360 - 12365.
[12]Chemical Communications,2011,vol. 47,p. 2435 - 2437.
[13]Chemical Communications,2014,vol. 50,p. 9329 - 9332.
[14]Tetrahedron,1982,vol. 38,p. 1203 - 1211.
[15]Chemical and pharmaceutical bulletin,1989,vol. 37,p. 373 - 376.
[16]Bioorganic and Medicinal Chemistry,2013,vol. 21,p. 7107 - 7117.
[17]Journal of Photochemistry and Photobiology B: Biology,2014,vol. 138,p. 75 - 79.
[18]Chemistry - An Asian Journal,2017,vol. 12,p. 936 - 946.
[19]Beilstein Journal of Organic Chemistry,2015,vol. 11,p. 563 - 567.

9
[ 122-51-0 ]
[ 99-07-0 ]
[ 41602-56-6 ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

10
[ 41602-56-6 ]
[ 120-92-3 ]
N,N,N',N'-Tetramethyl-2,11-diamino-cyclopenta<2,1-b:2,3-b'>bis<1>benzopyran [ No CAS ]

References: [1]Journal of Chemical Research, Miniprint,1983,p. 868 - 875.

11
[ 41602-56-6 ]
[ 589-15-1 ]
4-dimethylamino-2-(4-bromobenzyloxy)benzaldehyde [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

12
[ 41602-56-6 ]
[ 67-64-1 ]
N,N,N',N'-Tetramethyl-7,7'-diamino-2,2'-spirobi<2H-1-benzopyran> [ No CAS ]

References: [1]Journal of Chemical Research, Miniprint,1983,p. 868 - 875.

13
[ 41602-56-6 ]
[ 17201-43-3 ]
[ 101046-16-6 ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

14
[ 41602-56-6 ]
[ 100-11-8 ]
[ 96323-58-9 ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

15
[ 41602-56-6 ]
[ 105-53-3 ]
[ 55804-64-3 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 2975 - 2982.
[2]Journal of the American Chemical Society,2013,vol. 135,p. 12360 - 12365.
[3]Chemical and pharmaceutical bulletin,1989,vol. 37,p. 373 - 376.

16
[ 41602-56-6 ]
[ 107-91-5 ]
[ 79604-92-5 ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1981,vol. 323,p. 691 - 693.

17
[ 24589-97-7 ]
[ 41602-56-6 ]

References: [1]Journal of Medicinal Chemistry,1969,vol. 12,p. 420 - 424.

18
[ 41602-56-6 ]
[ 177093-50-4 ]
4-(7-Dimethylamino-2-oxo-2H-chromen-3-yl)-benzoic acid ethyl ester [ No CAS ]

References: [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 793 - 799.

19
[ 41602-56-6 ]
[ 1099-45-2 ]
7-(N,N-dimethylamino)-2-oxo-2H-chromene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	at 180℃; for 1h;Inert atmosphere;	4-N, N-dimethylamino-2-hydroxy-benzaldehyde (5 g, 30 mmol) and triphenylphosphinyloxyacetate (12 g,35 mmol) was heated to 180 C under argon for 1 h, cooled to room temperature,The crude product was purified by silica gel column chromatography to give 5.5 g of the desired product in 62% yield.
62%	at 180℃; for 1h;Inert atmosphere;	4-N, N-dimethylamino-2-hydroxy-benzaldehyde (5 g, 30 mmol)And triphenylphosphinylethyl acetate (12 g, 35 mmol)Heated to 180 C under argon for 1 h,Cool to room temperature,The crude product was purified by silica gel column chromatography to give the target product 5.5g, yield 62%.

References: [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 793 - 799.
[2]Molecules,2009,vol. 14,p. 4838 - 4848.
[3]Patent: CN106543126,2017,A .Location in patent: Paragraph 0028; 0029.
[4]Patent: CN106543125,2017,A .Location in patent: Paragraph 0020; 0028; 0029.

20
[ 41602-56-6 ]
[ 2026-11-1 ]
3-phenyl-7-(N,N-dimethylamino)coumarin [ No CAS ]

References: [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 793 - 799.
[2]Organic and Biomolecular Chemistry,2016,vol. 14,p. 5673 - 5682.

21
[ 41602-56-6 ]
4-Dimethylamino-2-hydroxy-benzaldehyde oxime [ No CAS ]

References: [1]Magnetic Resonance in Chemistry,1997,vol. 35,p. 778 - 784.

23
[ 41602-56-6 ]
[ 37722-34-2 ]
6-bromo-3,9-bis-dimethylamino-13,13-dimethyl-13H-7-oxa-5-oxonia-pentacene; perchlorate [ No CAS ]

References: [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 527 - 538.

24
[ 41602-56-6 ]
2-bromo-5,5-dimethyl-1,3-diethoxy-1-cyclohexenylium perchlorate [ No CAS ]
6-bromo-3,9-bis-dimethylamino-13,13-dimethyl-13H-7-oxa-5-oxonia-pentacene; perchlorate [ No CAS ]

References: [1]Russian Journal of Organic Chemistry,2001,vol. 37,p. 527 - 538.

25
[ 103-82-2 ]
[ 41602-56-6 ]
3-phenyl-7-(N,N-dimethylamino)coumarin [ No CAS ]

References: [1]Synthetic Communications,2004,vol. 34,p. 3129 - 3134.

26
[ 107-86-8 ]
[ 41602-56-6 ]
(1RS,9RS,11RS)-5-N,N-dimethylamino-9-methyl-8,12-dioxatricyclo[7.3.1.0^2,7]tri-deca-2,4,6-trien-11-ol [ No CAS ]

References: [1]Advanced Synthesis and Catalysis,2005,vol. 347,p. 555 - 562.

27
[ 41602-56-6 ]
[ 122607-15-2 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 2975 - 2982.
[2]Chemical and pharmaceutical bulletin,1989,vol. 37,p. 373 - 376.
[3]Journal of the American Chemical Society,2013,vol. 135,p. 12360 - 12365.

28
[ 41602-56-6 ]
7-Dimethylamino-2-oxo-2H-chromene-3-carboxylic acid (2-amino-ethyl)-amide [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 2975 - 2982.

29
[ 41602-56-6 ]
C₁₇H₁₉NO₆ [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 2975 - 2982.

30
[ 41602-56-6 ]
[ 160291-47-4 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 2975 - 2982.

31
[ 41602-56-6 ]
[ 160291-48-5 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 2975 - 2982.

32
[ 41602-56-6 ]
(Z)-3-{2-[(7-Dimethylamino-2-oxo-2H-chromene-3-carbonyl)-amino]-ethylcarbamoyl}-acrylic acid [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 2975 - 2982.

33
[ 41602-56-6 ]
[ 101046-20-2 ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

34
[ 41602-56-6 ]
[ 96323-60-3 ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

35
[ 41602-56-6 ]
4-(6-dimethylamino-2-benzofuranyl)benzoic acid [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

36
[ 41602-56-6 ]
4-(6-dimethylamino-2-benzofuranyl)phenyl isothiocyanate [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

37
[ 41602-56-6 ]
[ 96323-59-0 ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

38
[ 41602-56-6 ]
[ 101046-18-8 ]

References: [1]Bulletin of the Chemical Society of Japan,1985,vol. 58,p. 2192 - 2196.

39
[ 41602-56-6 ]
[ 53050-52-5 ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1981,vol. 323,p. 691 - 693.

40
[ 41602-56-6 ]
3-Cyano-7-dimethylamino-2-(dimethylamino-methyleneamino)-chromenylium; perchlorate [ No CAS ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1981,vol. 323,p. 691 - 693.

41
[ 99-07-0 ]
<3.6-bis-diethylamino-9-oxy-xanthyl>-benzene-pentacarboxylic acid [ No CAS ]
[ 41602-56-6 ]

References: [1]Journal of Organic Chemistry,1985,vol. 50,p. 2690 - 2698.

42
[ 41602-56-6 ]
[ 122607-32-3 ]