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Chemical Structure| 42524-21-0 Chemical Structure| 42524-21-0

Structure of 42524-21-0

Chemical Structure| 42524-21-0

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Product Details of [ 42524-21-0 ]

CAS No. :42524-21-0
Formula : C8H8BrNO2
M.W : 230.06
SMILES Code : C/C(C1=CC(Br)=CC=C1O)=N\O
MDL No. :MFCD26131157

Safety of [ 42524-21-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 42524-21-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 42524-21-0 ]

[ 42524-21-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1450-75-5 ]
  • [ 5676-56-2 ]
  • [ 42524-21-0 ]
YieldReaction ConditionsOperation in experiment
65%; 7% With acetylhydroxamic acid; sulfuric acid; In acetonitrile; at 80℃; under 1292.9 Torr; for 0.166667h;Microwave irradiation; General procedure: 2-Hydroxy acetophenone 4a (1.0 g, 7.4 mmol), acetohydroxamic acid (0.83 g, 11.0 mmol), acetonitrile (3 ml), and conc. H2SO4 (0.2 ml) were taken into a 10 ml pressure tube and subjected to microwave heating (CEM discover, 360 W, 80 C, 25 psi) for 8 min. Next, the reaction mixture was diluted with ethyl acetate (3 ml) and to this; saturated sodium bicarbonate solution (5 ml) was added drop-wise. The mixture was extracted with ethyl acetate (2 × 10 ml) and the combined organic layer was washed with saturated NaCl solution, dried over anhy. Na2SO4, and concentrated under reduced pressure. Purification of the mixture by normal column chromatography (silica gel 60-120 mesh, ethyl acetate/hexane: 1:9) gave benzoxazole 5a (0.67 g, 70%) in the form of a yellow oil and 2-hydroxy acetophenone oxime 6a (68 mg, 6%, mp 104-107 C) in the form of a white powder.
  • 2
  • [ 1450-75-5 ]
  • [ 5676-56-2 ]
  • [ 42524-21-0 ]
  • [ 6329-74-4 ]
  • 3
  • [ 42524-21-0 ]
  • [ 5676-56-2 ]
 

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