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Chemical Structure| 426463-01-6 Chemical Structure| 426463-01-6

Structure of 426463-01-6

Chemical Structure| 426463-01-6

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Product Details of [ 426463-01-6 ]

CAS No. :426463-01-6
Formula : C5H6IN3
M.W : 235.03
SMILES Code : NC1=NC=C(I)C=C1N
MDL No. :MFCD10697693

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 426463-01-6 ]

[ 426463-01-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 27258-32-8 ]
  • [ 426463-01-6 ]
  • 5-iodo-N3-((1-methyl-1H-pyrazol-3-yl)methyl)pyridine-2,3-diamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.325 g A mixture of <strong>[27258-32-8]1-methyl-1H-pyrazole-3-carbaldehyde</strong> (0.516 g) and 5-iodopyridine-2,3-diamine (1 g), acetic acid (0.256 mL) and THF (20 mL) was stirred at room temperature for 21 hours. The mixture was neutralized with a saturated aqueous sodium hydrogen carbonate solution, and extracted with THF and ethyl acetate. The organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution and a saturated brine, dried over magnesium sulfate, and then concentrated to obtain a residue. Sodium borohydride (0.485 g) was added to a solution of the residue in THF (40 mL)/methanol (10 mL) at 0°C, and the mixture was stirred at room temperature for 1 hour. The reaction was stopped with water and a saturated aqueous ammonium chloride solution at room temperature, and the mixture was basified, and extracted with ethyl acetate. The organic layer was washed with a saturated brine, then dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol) to obtain the title compound (0.325 g). MS: [M+H]+ 330.1.
 

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