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Chemical Structure| 42729-56-6 Chemical Structure| 42729-56-6

Structure of 42729-56-6

Chemical Structure| 42729-56-6

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Product Details of [ 42729-56-6 ]

CAS No. :42729-56-6
Formula : C7H15NO
M.W : 129.20
SMILES Code : OC1CN(C(C)C)CC1
MDL No. :MFCD00191525

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Application In Synthesis of [ 42729-56-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 42729-56-6 ]

[ 42729-56-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42729-56-6 ]
  • [ 24985-85-1 ]
  • [ 872030-34-7 ]
YieldReaction ConditionsOperation in experiment
44% With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 20℃; Example 5; 5-(1-Isopropyl-pyrrolidin-3-yloxJr)-1H-indole-2-carbox7rlic acid cyclopropylmethyl- propyl-amide; a) Step 1: 5-(l-isopropyl-pyrrolidin-3-yloxy)-lH-indole-2-carboxylic acid ethyl ester; A mixture of 3.08 g (15 mmol) 5-hydroxy-lH-indole-2-carboxylic acid ethyl ester, 2.51 g (20 mmol) 1-isopropyl-3-pyrrolidinol and 8.7 ml (30 mmol) tri-N-butyl phospine in 75 ml was treated at room temperature with 7.57 g (30 mmol) 1,1'-(azodicarbonyl)- dipiperidine in 75 ml THF. The mixture was allowed to stir for a prolonged period of time and subsequently evaporated to dryness. The residue was suspended in 40 ml DCM/n- heptane 1/1, filtered and again washed with 40 ml DCM/n-heptane 1/1. The filtrate was evaporated and purified on silica eluting with a gradient of DCM/ 2N NH3 in methanol 99/1 to DCM/ 2N NH3 in methanol 93/7. The product fractions were evaporated and the residue was titurated with diethyl ether to yield after filtration, washing and drying of the residue at 50 C under vacuum 2.1 g (44 %) of the title compound as off-white solid. MS (m/e): 317.1 (MH+, 100%).
 

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