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Chemical Structure| 4337-43-3 Chemical Structure| 4337-43-3

Structure of 4337-43-3

Chemical Structure| 4337-43-3

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Product Details of [ 4337-43-3 ]

CAS No. :4337-43-3
Formula : C7H4ClNOS
M.W : 185.63
SMILES Code : O=C1NSC2=CC=C(Cl)C=C12
MDL No. :MFCD01659015

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Application In Synthesis of [ 4337-43-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4337-43-3 ]

[ 4337-43-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50-00-0 ]
  • [ 4337-43-3 ]
  • [ 59878-57-8 ]
  • 5-chloro-2-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)benzo[d]isothiazol-3(2H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% In methanol; at 0℃; [0138] To a solution of 37% aq. formaldehyde (15 uL) in MeCH (1 mL) was added 5-chlorobenzoisothiazol-3-one (25 mg, 0.13 mmol) and cyclopropyl(piperazin1-yl)methanone (20 mg, 0.13 mmol). The resulting suspension was stirred for several days, cooled to 0C and resulting precipitate was filtered to give the title compound as a white powder (35.6 mg, 78% yield). 1H NMR (400 MHz, CDCI3) O 8.00 (d, 1 H), 7.59 (dd, 1 H), 7.48 (d, 2H), 4.72 (5, 2H), 3.68 (bds, 4H), 2.73 (bds, 4H), 1.68(m, 1H), 0.96(m, 1H), 0.74(m, 1H).
 

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