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[ CAS No. 4341-02-0 ] {[proInfo.proName]}

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Chemical Structure| 4341-02-0
Chemical Structure| 4341-02-0
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Product Details of [ 4341-02-0 ]

CAS No. :4341-02-0 MDL No. :MFCD01312162
Formula : C14H8N2 Boiling Point : -
Linear Structure Formula :- InChI Key :XDQREGRMKWTMOO-UHFFFAOYSA-N
M.W : 204.23 Pubchem ID :266827
Synonyms :

Safety of [ 4341-02-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 UN#:N/A
Hazard Statements:H302+H312+H332-H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 4341-02-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4341-02-0 ]

[ 4341-02-0 ] Synthesis Path-Downstream   1~68

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  • [ 344-04-7 ]
  • [ 4387-36-4 ]
  • [ 4341-02-0 ]
  • [ 434-90-2 ]
  • 2',3',4',5',6'-pentafluorobiphenyl-2-carbonitrile [ No CAS ]
  • 5
  • [ 4341-02-0 ]
  • [ 14034-59-4 ]
  • [ 126664-76-4 ]
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  • [ 2042-37-7 ]
  • [ 4341-02-0 ]
YieldReaction ConditionsOperation in experiment
91% With manganese; zirconocene dichloride; [(2,9-dimethyl-1,10-phenanthroline)dichloro nickel(II)]; lithium chloride; In 1,2-dimethoxyethane; at 20℃; for 1h;Inert atmosphere; General procedure: To a suspension of a NiCl2-complex (0.01 mmol, 0.02 equiv), Zr(cp)2Cl2 (Strem, 99%; 7.3 mg, 0.025 mmol, 0.05 equiv), Mn powder (Aldrich, 99.99%; 54.9 mg, 1.0 mmol, 2.0 equiv) and LiCl (Aldrich, anhydrous, ground powder; 42.4 mg, 1.0 mmol, 2.0 equiv) in DME (Aldrich, anhydrous, 99.5%; 1.0 mL) was added an iodide (0.5 mmol) under nitrogen. The mixture was stirred at rt under nitrogen until the reaction completed (TLC). Except for the dipyridyls, the mixture was loaded on silica gel directly, and the flash chromatography on silica gel gave the homo-coupling product. For dipyridyls, the reaction was quenched with aq. NH4OH (27% w/w, 0.6 mL), stirred for 10 min, extracted with CH2Cl2 (10 mL × 3), washed with brine (15 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel to give the homocoupling product. For alkenyl halide substrates (Fig. 3 and Table 3), the reaction was done in 0.2 mmol scale (C: 0.5 M) with added toluene (42 μl, 0.4 mmol, 2.0 equiv) as an internal standard. After the reaction was completed, a small portion (50 μL) of the mixture was passed through a small silica pad, and eluted with CDCl3 (1 mL). The yield was estimated from 1H NMR (600 MHz, CDCl3).
65% With bis-triphenylphosphine-palladium(II) chloride; 1,1'-dioctyl-4,4'-bipyridinium bis(trifluimide); tetrabutylammonium bis[(trifluoromethane)sulfonyl]imide; In 1-methyl-pyrrolidin-2-one; at 60℃;Electrochemical reaction; A typical procedure of the electroreductive coupling of aryl bromide1 with catalytic amounts of [OctV2+][Tf2N]2 and Pd species isas follows. Into an undivided cell fitted with a Zn anode(1.5 1 cm2) and a Pt cathode (1.5 1 cm2) was added a DMF(3 mL) solution of 4-bromopropiophenone (1a, 0.25 mmol),[Bu4N+][Tf2N] (0.3 mmol), [OctV2+][Tf2N]2 (0.075 mmol,30 mol %), and PdCl2(PPh3)2 (0.0125 mmol, 5 mol %). The wholemixture was electrolyzed at 60 C under constant current(10 mA) conditions until 2 F/mol-1a of electricity was passed.The reaction mixture was poured into 5% aq HCl and extractedwith AcOEt. Purification by column chromatography (SiO2, toluene/AcOEt = 10/1) afforded 4,40-dipropanoylbiphenyl (2a) in 94%yield
61% With bis-triphenylphosphine-palladium(II) chloride; 1,1',1"-[benzene-1,3,5-triyltris(methylene)]tris[(octyl)-4-pyridin-4-ylpyridinium] hexafluorophosphate; tetrabutylammonium bis[(trifluoromethane)sulfonyl]imide; In N,N-dimethyl-formamide; at 60℃;Electrochemical reaction; General procedure: In an undivided cellequipped with a Zn sacrificial anode (1.5 x 1.0 cm2) and a Pt cathode (1.5 x 1.0 cm2) was placed a DMF(3 mL) solution of 4-bromopropiophenone (4a, 0.053 g, 0.25 mmol), 1 (0.14 g, 7.6 x 10-2 mmol),[Bu4N+][Tf2N-] (0.16 g, 0.30 mmol), and a catalytic amount of PdCl2(PPh3)2 (0.0086 g, 1.2 x 10-2 mmol).The solution was electrolyzed under constant current conditions (10 mA) at 60 C until 2 F/mol-4a ofelectricity was passed. The reaction mixture was poured into 5% aq. HCl (12 mL). The mixture wasextracted with AcOEt (10 mL x 3). The combined organic layer was washed successively with waterand brine, dried (Na2SO4), and concentrated under reduced pressure. The residue was purified bycolumn chromatography (SiO2, toluene/AcOEt = 10/1) to afford 4,4’-dipropanoylbiphenyl (5a, 0.030 g,0.11 mmol, 89%).
  • 8
  • [ 100-47-0 ]
  • [ 108-95-2 ]
  • [ 1591-30-6 ]
  • [ 36852-02-5 ]
  • [ 4341-02-0 ]
  • [ 42289-54-3 ]
  • [ 42289-52-1 ]
  • [ 42289-51-0 ]
  • 9
  • [ 591-50-4 ]
  • [ 4387-36-4 ]
  • [ 4341-02-0 ]
  • 10
  • [ 13029-09-9 ]
  • [ 544-92-3 ]
  • [ 4341-02-0 ]
  • 12
  • [ 544-92-3 ]
  • [ 2236-52-4 ]
  • [ 4341-02-0 ]
  • 14
  • [ 79048-34-3 ]
  • [ 4341-02-0 ]
YieldReaction ConditionsOperation in experiment
24.3 mg (47%) EXAMPLE 37 STR129 To a stirred solution of 53.1 mg (0.1 mmole) of crude oxime from Example 36 in 1.6 mL of sieve dried CH2 Cl2 at -78 C. under a nitrogen atmosphere was added sequentially 21.9 mg (0.22 mmole) of neat triethylamine and 29.1 mg (0.1 mmole) of neat triflic anhydride. After stirring 15 minutes at -78 C., an additional 13.4 mg (0.05 mmole) of triflic anhydride was added and the mixture stirred further for 15 minutes. The mixture was partitioned between EtOAc/ice/saturated NH4 Cl (aq.) solution and the organic phase was separated, washed with saturated NaHCO3 (aq.) solution/ice and then brine, dried over Na2 SO4, filtered, and evaporated. The residue was purified by PLC [one development 5% EtOAc in CH2 Cl2 ] to give 24.3 mg (47%) of biphenylnitrile carbapenem derivative., IR (CH2 Cl2) 2235, 1780, 1745, and 1720 cm-1; NMR (CDCl3) δ: 1.5 (d, CH3), 3.29 (m, 2H-1), 3.46 (dd, 1H-6), 4.34 (td, 1H-5), 4.66 (m, 2--OCH2 CH=CH2), 5.26 (m, 1H-8 and 2--CH=CH2), 5.88 (m, 2CH=CH2), 7.38-7.83 (m, Ar--H).
24.3 mg (47%) EXAMPLE 37 STR57 To a stirred solution of 53.1 mg (0.1 mmole) of crude oxime from Example 36 in 1.6 mL of sieve dried CH2 Cl2 at -78 C. under a nitrogen atmosphere was added sequentially 21.9 mg (0.22 mmole) of neat triethylamine and 29.1 mg (0.1 mmole) of neat triflic anhydride. After stirring 15 minutes at -78 C., an additional 13.4 mg (0.05 mmole) of triflic anhydride was added and the mixture stirred further for 15 minutes. The mixture was partitioned between EtOAc/ice/saturated NH4 Cl (aq.) solution and the organic phase was separated, washed with saturated NaHCO3 (aq.) solution/ice and then brine, dried over Na2 SO4, filtered, and evaporated. The residue was purified by PLC [one development 5% EtOAc in CH2 Cl2 ] to give 24.3 mg (47%) of biphenylnitrile carbapenem derivative; IR (CH2 Cl2) 2235, 1780, 1745, and 1720 cm-1; NMR (CDCl3) δ: 1.5 (d, CH3), 3.29 (m, 2H-1), 3.46 (dd, 1H-6), 4.34 (td, 1H-5), 4.66 (m, 2--OCH2 CH=CH2), 5.26 (m, 1H-8 and 2--CH=CH2), 5.88 (m, 2CH=2), 7.38-7.83 (m, Ar-H).
  • 16
  • [ 4387-36-4 ]
  • copper-powder [ No CAS ]
  • [ 4341-02-0 ]
  • 17
  • [ 4341-02-0 ]
  • [ 7664-93-9 ]
  • [ 6747-35-9 ]
  • [ 863305-32-2 ]
  • 18
  • [ 104-92-7 ]
  • [ 544-97-8 ]
  • [ 104-93-8 ]
  • [ 4341-02-0 ]
  • 19
  • [ 2042-37-7 ]
  • [ 544-97-8 ]
  • [ 529-19-1 ]
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  • 21
  • [ 10419-32-6 ]
  • [ 2042-37-7 ]
  • [ 4341-02-0 ]
  • 2-(3-methoxy-benzo[<i>b</i>]thiophen-2-yl)-benzonitrile [ No CAS ]
  • 22
  • [ 5798-75-4 ]
  • [ 2042-37-7 ]
  • [ 4341-02-0 ]
  • [ 47230-38-6 ]
  • [ 100-47-0 ]
  • [ 501427-88-9 ]
  • 23
  • [ 696-62-8 ]
  • [ 2042-37-7 ]
  • [ 4341-02-0 ]
  • [ 2132-80-1 ]
  • [ 125610-78-8 ]
  • [ 100-47-0 ]
  • 24
  • [ 2042-37-7 ]
  • [ 401-81-0 ]
  • [ 4341-02-0 ]
  • [ 580-82-5 ]
  • [ 100-47-0 ]
  • 3'-(trifluoromethyl)-[1,1'-biphenyl]-2-carbonitrile [ No CAS ]
  • 25
  • [ 873-32-5 ]
  • [ 591-87-7 ]
  • [ 4341-02-0 ]
  • [ 61463-61-4 ]
  • [ 100-47-0 ]
YieldReaction ConditionsOperation in experiment
3%; 83%; 14% With manganese;cobalt(II) bromide; iron(II) bromide; In pyridine; acetonitrile; at 50℃; [0266] Allyl acetate (10 mmol) and aryl chloride (5 mmol) are introduced into a pyridine acetonitrile solution (AN=20 ml/Py=2 ml) that contains manganese dust (50 mmol), cobalt bromide dust (2 mmol), and ferrous bromide dust (5 mmol). The reaction mixture is brought to 50 C. and is stirred until aryl chloride completely disappears (not detectable in gas chromatography).
  • 26
  • [ 591-87-7 ]
  • [ 2042-37-7 ]
  • [ 4341-02-0 ]
  • [ 61463-61-4 ]
  • [ 100-47-0 ]
  • 27
  • [ 2549-31-7 ]
  • [ 4341-02-0 ]
  • [ 781-43-1 ]
  • [ 56153-61-8 ]
  • [ 604-83-1 ]
  • 28
  • [ 5381-20-4 ]
  • [ 2042-37-7 ]
  • [ 4341-02-0 ]
  • 2-(2'-benzonitrile)-benzo[b]thiophene-3-carboxaldehyde [ No CAS ]
  • 29
  • [ 2236-52-4 ]
  • CuCN [ No CAS ]
  • [ 4341-02-0 ]
  • [ 36271-73-5 ]
  • 30
  • (2-cyanophenyl)magnesium chloride [ No CAS ]
  • [ 4341-02-0 ]
  • 31
  • [ 120914-99-0 ]
  • [ 4341-02-0 ]
  • [ 85-01-8 ]
  • [ 100-47-0 ]
  • 32
  • [ 1003046-47-6 ]
  • [ 623-03-0 ]
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  • [ 85-01-8 ]
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  • [ 1003046-49-8 ]
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  • [ 85-01-8 ]
  • [ 104-85-8 ]
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  • [ 4341-02-0 ]
  • [ 107011-08-5 ]
  • 35
  • [ 583-55-1 ]
  • [ 4341-02-0 ]
  • 36
  • [ 153915-36-7 ]
  • [ 153915-34-5 ]
  • [ 4341-02-0 ]
YieldReaction ConditionsOperation in experiment
83% With trichlorophosphate; In pyridine; EXAMPLE 5 cis-4-[4-(2'-Cyanophenyl)phenylmethyl]-2,6-dimethylmorpholine To a solution of cis-2,6-dimethyl-4-[2'-(4,4-dimethyl-2-oxazolinyl)phenyl]-phenylmethylmorpholine (1.302 g, 3.44 mmol) in 6.0 mL of pyridine at 0 C. was slowly added phosphorous oxychloride (0.50 mL, 5.36 mmol). After 15 minutes at room temperature the mixture was heated to 100 C. for 4 hours. The mixture was cooled to room temperature, was quenched with water (20 mL), then was extracted 3*50 mL with EtOAc. The combined extracts were dried over Na2 SO4 and concentrated under reduced pressure to give the biphenyl nitrile (0.870 g, 83%) as a tan solid with spectral characteristics identical to those reported above in Example 3. STR21
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  • [ 7440-66-6 ]
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  • [ 131379-17-4 ]
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  • [ 873-32-5 ]
  • [ 1126-46-1 ]
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  • [ 89900-98-1 ]
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  • [ 873-32-5 ]
  • [ 106-38-7 ]
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  • [ 114772-53-1 ]
  • 40
  • [ 5798-75-4 ]
  • [ 2042-37-7 ]
  • [ 4341-02-0 ]
  • [ 501427-88-9 ]
  • 41
  • (2-cyanophenyl)magnesium chloride [ No CAS ]
  • [ 4890-63-5 ]
  • [ 4341-02-0 ]
  • [ 886-66-8 ]
  • [ 32183-76-9 ]
  • 42
  • (2-cyanophenyl)magnesium chloride [ No CAS ]
  • [ 5713-61-1 ]
  • [ 4341-02-0 ]
  • [ 492-97-7 ]
  • [ 125610-77-7 ]
  • 44
  • 4,5-bis(p-tert-butylphenyl)phthalonitrile [ No CAS ]
  • [ 4341-02-0 ]
  • [ 1289556-17-7 ]
  • Ni[C32H8N8(C6H4C4H9)8] [ No CAS ]
  • 45
  • 4,5-bis(4-tert-butylphenoxy)-1,2-dicyanobenzene [ No CAS ]
  • [ 4341-02-0 ]
  • [ 1329995-36-9 ]
  • Ni[C32H8N8(OC6H4C4H9)8] [ No CAS ]
  • 46
  • 4,5-bis(4-tert-butylphenoxy)-1,2-dicyanobenzene [ No CAS ]
  • [ 91-22-5 ]
  • [ 4341-02-0 ]
  • nickel diacetate [ No CAS ]
  • [ 1329995-36-9 ]
  • Ni[C32H8N8(OC6H4C4H9)8] [ No CAS ]
  • 47
  • 4,5-bis(p-tert-butylphenyl)phthalonitrile [ No CAS ]
  • [ 91-22-5 ]
  • [ 4341-02-0 ]
  • nickel diacetate [ No CAS ]
  • [ 1289556-17-7 ]
  • Ni[C32H8N8(C6H4C4H9)8] [ No CAS ]
  • 48
  • [ 4341-02-0 ]
  • [ 1835-65-0 ]
  • [ 10294-34-5 ]
  • dodecafluorosubphthalocyanatoboron(III) chloride [ No CAS ]
  • [ 1588942-19-1 ]
  • 49
  • [ 84-11-7 ]
  • [ 4341-02-0 ]
  • 50
  • [ 4341-02-0 ]
  • [ 106-49-0 ]
  • 5-(p-tolylimino)-5H-dibenzo[c,e]azepin-7-amine [ No CAS ]
  • 51
  • [ 504-29-0 ]
  • [ 4341-02-0 ]
  • [7-amino-dibenzo[c,e]acepin-(5Z)-yliden]-pyridin-2-ylamine [ No CAS ]
  • 52
  • [ 4341-02-0 ]
  • [ 57-14-7 ]
  • 7-(dimethyl-hydrazono)-7H-dibenzo[c,e]-azepin-5-ylamine [ No CAS ]
  • 53
  • [ 131379-17-4 ]
  • [ 4341-02-0 ]
YieldReaction ConditionsOperation in experiment
With p-benzoquinone; cobalt(II) bromide; In acetonitrile; at 20℃; General procedure: Oxidative Synthesis of Symmetrical Biaryl Using p-Benzoquinone as Oxidant; General Procedure To a solution of CoBr2 (220 mg, 1 mmol, 13 mol%) and zinc powder(1.3 g, 20 mmol) in MeCN (5 mL) were successively added at r.t. allylchloride (250 μL, 3 mmol) and TFA (50 μL), causing an immediate risein temperature and color change to dark grey. After stirring the re-sulting mixture for 3 min, aryl bromide (7.5 mmol) was added. Themedium was then stirred at r.t. until the aryl halide was consumed.The amount of the corresponding organozinc species was measuredby reaction with I2 and GC analysis using an internal reference (do-decane 100 μL). When the aromatic halide had been consumed, p-benzoquinone (405 mg, 3.75 mmol) was added and the mixture wasstirred overnight. The mixture was hydrolyzed by 2 M HCl and ex-tracted with Et2O. The organic layer was dried (MgSO4). Evaporationof solvent and purification by column chromatography (silica gel, pe-troleum ether/Et2O) afforded the symmetrical biaryl characterized byNMR (1H, 13C).
  • 57
  • bis(trimethylsilyl)acetylenetitanocene [ No CAS ]
  • [ 4341-02-0 ]
  • C24H18N2Ti [ No CAS ]
  • 58
  • [ 4341-02-0 ]
  • [ 762-42-5 ]
  • dimethyl dibenzo[f,h]quinoxaline-2,3-dicarboxylate [ No CAS ]
  • 59
  • [ 14447-02-0 ]
  • [ 4341-02-0 ]
  • dipropyl dibenzo[f,h]quinoxaline-2,3-dicarboxylate [ No CAS ]
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  • [ 2042-37-7 ]
  • [ 4341-02-0 ]
  • [ 100-47-0 ]
  • 61
  • [ 530-48-3 ]
  • [ 874-05-5 ]
  • [ 4341-02-0 ]
  • 2-(2,2-diphenylethenyl)benzonitrile [ No CAS ]
  • 62
  • [ 4341-02-0 ]
  • [ 16419-60-6 ]
  • 7-(o-tolyl)-5H-dibenzo[c,e]azepin-5-ketone [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% With methanesulfonic acid; palladium(II) acetylacetonate; In N,N-dimethyl acetamide; at 110℃; for 24h;Sealed tube; In an air atmosphere, add the raw material [1,1'-biphenyl]-2,2'-dinitrile (0.4mmol) to a 25ml sealed tube, o-methylphenylboronic acid (0.8 mmol), catalyst palladium diacetylacetonate (5 mol%), N, N-dimethylacetamide (2mL) and methanesulfonic acid (4mmol), and then reacted at 110 C for 24h to obtain 7-(o-tolyl)-5H-dibenzo[c,e]azepin-5-one; the final product yield was 93%;
  • 63
  • [ 4341-02-0 ]
  • [ 1679-18-1 ]
  • 7-(4-chlorophenyl)-5H-dibenzo[c,e]azepin-5-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With methanesulfonic acid; palladium(II) acetylacetonate; In N,N-dimethyl acetamide; at 110℃; for 24h;Sealed tube; In the air atmosphere, add the raw material [1,1'-biphenyl]-2,2'-dinitrile (0.4mmol) to a 25ml sealed tube, p-chlorophenylboronic acid (0.8 mmol), palladium diacetylacetonate (5 mol%), N,N-dimethylacetamide (2 mL) and methanesulfonic acid (4 mmol), then reacted at 110C for 24h, obtained 7-(4-chlorophenyl)-5H-dibenzo[c,e]azepin-5-one; the yield of the final product was 89%;
  • 64
  • [ 4341-02-0 ]
  • [ 5467-74-3 ]
  • 7-(4-bromophenyl)-5H-dibenzo[c,e]azepin-5-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% With methanesulfonic acid; palladium(II) acetylacetonate; In N,N-dimethyl acetamide; at 110℃; for 24h;Sealed tube; In the atmosphere, add the raw material [1,1'-biphenyl]-2,2'-dinitrile (0.4mmol) to a 25ml sealed tube, p-bromophenylboronic acid (0.8 mmol), catalyst palladium diacetylacetonate (5 mol%), N,N-dimethylacetamide (2 mL) and methanesulfonic acid (4 mmol), then reacted at 110C for 24h, 7-(4-bromophenyl)-5H-dibenzo[c,e]azepin-5-one was obtained; the yield of the final product was 83%;
  • 65
  • [ 4341-02-0 ]
  • [ 5122-99-6 ]
  • 7-(4-iodophenyl)-5H-dibenzo[c,e]azepin-5-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With methanesulfonic acid; palladium(II) acetylacetonate; In N,N-dimethyl acetamide; at 110℃; for 24h;Sealed tube; In an air atmosphere, add the raw material [1,1'-biphenyl]-2,2'-dinitrile (0.4mmol) to a 25ml sealed tube, p-iodophenylboronic acid (0.8 mmol), catalyst diacetylacetonate palladium (5mol%), N,N-dimethylacetamide (2 mL) and methanesulfonic acid (4 mmol), then it was reacted at 110C for 24 hours to obtain 7-(4-iodophenyl)-5H-dibenzo[c,e]aza-5-one; the final product yield is 80%;
  • 66
  • [ 4341-02-0 ]
  • [ 5122-94-1 ]
  • 7-([1,1'-biphenyl]-4-yl)-5H-dibenzo[c,e]azepin-5-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With methanesulfonic acid; palladium(II) acetylacetonate; In N,N-dimethyl acetamide; at 110℃; for 24h;Sealed tube; In an air atmosphere, add the raw material [1,1'-biphenyl]-2,2'-dinitrile (0.4mmol) to a 25ml sealed tube, 4-phenylphenylboronic acid (0.8mmol), catalyst diacetylacetonate palladium (5mol%), N,N-dimethylacetamide (2 mL) and methanesulfonic acid (4 mmol), then reacted at 110C for 24h, 7-([1,1'-biphenyl]-4-yl)-5H-dibenzo[c,e]aza-5-one was obtained; the yield of the final product was 73%;
  • 67
  • [ 4341-02-0 ]
  • [ 13922-41-3 ]
  • 7-(naphthalene-1-yl)-5H-dibenzo[c,e]azepin-5-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With methanesulfonic acid; palladium(II) acetylacetonate; In N,N-dimethyl acetamide; at 110℃; for 24h;Sealed tube; In an air atmosphere, add the raw material [1,1'-biphenyl]-2,2'-dinitrile (0.4mmol) to a 25ml sealed tube, 1-naphthaleneboronic acid (0.8mmol), catalyst palladium diacetylacetonate (5mol%), N,N-dimethylacetamide (2 mL) and methanesulfonic acid (4 mmol), then, it was reacted at 110C for 24 hours to obtain 7-(naphthalene-1-yl)-5H-dibenzo[c,e]azepin-5-one; the yield of the final product is 75%;
  • 68
  • [ 4341-02-0 ]
  • [ 98-80-6 ]
  • 7-phenyl-5H-dibenzo[c,e]azepin-5-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With methanesulfonic acid; palladium(II) acetylacetonate; In N,N-dimethyl acetamide; at 110℃; for 24h;Sealed tube; Under air atmosphere, add raw materials to 25ml sealed tube in sequence [1,1'-biphenyl]-2,2'-dinitrile (0.4 mmol), phenylboronic acid (0.8mmol), catalyst diacetylacetonate palladium (5mol%), N,N-dimethylacetamide (2 mL) and methanesulfonic acid (4 mmol), then it was reacted at 110C for 24 hours to obtain 7-phenyl-5H-dibenzo[c,e]aza-5-one; the final product yield is 95%;
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Chemical Structure| 37580-53-3

[ 37580-53-3 ]

2-Methyl-[1,1'-biphenyl]-3-carbonitrile

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Chemical Structure| 917839-33-9

[ 917839-33-9 ]

4,5-Dimethyl-[1,1'-biphenyl]-2,4'-dicarbonitrile

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Chemical Structure| 42289-52-1

[ 42289-52-1 ]

[1,1'-Biphenyl]-2,4'-dicarbonitrile

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