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Chemical Structure| 4350-41-8 Chemical Structure| 4350-41-8

Structure of 4350-41-8

Chemical Structure| 4350-41-8

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Product Details of [ 4350-41-8 ]

CAS No. :4350-41-8
Formula : C12H10ClN
M.W : 203.67
SMILES Code : ClC1=CC=C(CC2=NC=CC=C2)C=C1
MDL No. :MFCD00006353
InChI Key :XSVWMIMFDMJQRL-UHFFFAOYSA-N
Pubchem ID :78054

Safety of [ 4350-41-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H332-H335
Precautionary Statements:P261-P280

Application In Synthesis of [ 4350-41-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4350-41-8 ]

[ 4350-41-8 ] Synthesis Path-Downstream   1~2

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  • [ 4350-41-8 ]
  • [ 27652-89-7 ]
  • 2
  • [ 27652-89-7 ]
  • [ 4350-41-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogen iodide; acetic acid; In water; at 140℃; for 10h; General procedure: In a pressure tube aq ~57percent HI (155 muL, 2 mmol) and phenyl-2-pyridylmethanol derivative (1 mmol) in AcOH (3 mL) was stirred at 140 °C. The reaction was monitored by TLC. After 10 h, the reaction mixture was diluted with H2O and neutralized by aq NaHCO3. The resulting aqueous layer was extracted with EtOAc (3 × 5 mL) and the combined organic layers were washed with sat. aq Na2S2O3 to remove the I2 generated during the reaction. Then the organic layer was dried (anhyd Na2SO4) and evaporated in vaccuo and the resulting residue was purified by silica gel column chromatography (eluents: hexanes/EtOAc) to give the pure 2-benzylpyridine derivative 1a?i in good yield.
 

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