Home Cart Sign in  
Chemical Structure| 438019-67-1 Chemical Structure| 438019-67-1

Structure of 438019-67-1

Chemical Structure| 438019-67-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 438019-67-1 ]

CAS No. :438019-67-1
Formula : C9H7F3N4
M.W : 228.17
SMILES Code : NC1=CC(C(F)(F)F)=CC=C1N2N=CN=C2
MDL No. :MFCD02712729

Safety of [ 438019-67-1 ]

Application In Synthesis of [ 438019-67-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 438019-67-1 ]

[ 438019-67-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 438019-67-1 ]
  • [ 459-04-1 ]
  • [ 1276284-64-0 ]
YieldReaction ConditionsOperation in experiment
33.8% With sodium hydrogencarbonate; In acetonitrile; at 55℃; for 0.75h;Microwave irradiation; Example 2-(4-fluorophenyl)-/V-[2-(1 H-1 ,2,4-triazol-1 -yl)-5-(trifluoromethyl)phenyl]- acetamide[2-(1 H-1 ,2,4-triazol-1 -yl)-5-(trifluoromethyl)phenyl]amine (ENAMINE, 30 mg, 0.131 mmol) was dissolved in acetonitrile (2 ml). Sodium bicarbonate (12 mg, 0.146 mmol) was added followed by (4-fluorophenyl)acetyl chloride (ALDRICH, 0.020 mL, 0.146 mmol). Reaction was heated 45 min at 55C under MW irradiation. Solution was concentrated to dryness and crude was purified by silica chromatography using hexane/EtOAc as eluents. 2-(4- fluorophenyl)-/V-[2-(1 /-/-1 ,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-acetamide (18 mg, 0.049 mmol, 33.8% yield) was obtained. 1 H NMR (400 MHz, CDCI3) δ ppm: 9.62 (s, 1 H), 8.93 (s, 1 H), 8.41 (s, 1 H), 7.90 (s, 1 H), 7.45 (t, 1 H), 7.43 (t, 1 H),7.21-7.25 (m, 1 H), 7.09 (t, 2H), 7.07 (t, 1 H), 3.73 (s, 2H). [ES+ MS] m/z 365 (MH+).
 

Historical Records

Technical Information

Categories