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Chemical Structure| 4388-97-0 Chemical Structure| 4388-97-0

Structure of 4388-97-0

Chemical Structure| 4388-97-0

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Product Details of [ 4388-97-0 ]

CAS No. :4388-97-0
Formula : C4H9NO2
M.W : 103.12
SMILES Code : NCC1OCCO1
MDL No. :MFCD00142862
InChI Key :QXXRLUXAOFVOTE-UHFFFAOYSA-N
Pubchem ID :10855394

Safety of [ 4388-97-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319
Precautionary Statements:P305+P351+P338
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 4388-97-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4388-97-0 ]

[ 4388-97-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5683-31-8 ]
  • [ 4388-97-0 ]
  • N-((1,3-dioxolan-2-yl)methyl)-3-(trimethylsilyl)propiolamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% Isobutyl chloroformate (970 mg, 7.1 mmol) was dropwise added to a solution of <strong>[5683-31-8]3-(trimethylsilyl)propiolic acid</strong> 25 (1010 mg, 7.1 mmol) and NMM (934 mg, 9.2 mmol) in THF (10 mL) at -40 oC. The reaction was stirred at -40 to -10 oC for 40 min. A solution of (1,3-dioxolan-2-yl)methanamine 32 (879 mg, 8.5 mmol) and NMM (934 mg, 9.2 mmol) in THF (10 mL) was slowly added to the reaction solution at -40 oC for 20 min. The mixture slowly recovered to r.t. from -40oC and was stirred overnight at r.t.. After concentration, the residue was dissolved in CH2Cl2, washed by NaHCO3 and brine, dried by Na2SO4 and purified by silica gel column chromatography (10% EtOAc/Hexanes, then 5-15% iPrOH/Hexanes stepwise gradient by 5%,) to afford 33. Yield: 1335 mg, 83%. 1H NMR (CDCl3, 600 MHz) 6.18 (b, 1H, NH), 4.97-4.99 (m, 1H), 4.01-4.03 (m, 2H), 3.90-3.93 (m, 2H), 3.51-3.53 (m, 2H), 0.22 (d, 9H). MS (ESI) [M+H]+ 228.3, found 228.0.
 

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