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Chemical Structure| 4485-89-6 Chemical Structure| 4485-89-6

Structure of 4485-89-6

Chemical Structure| 4485-89-6

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Product Details of [ 4485-89-6 ]

CAS No. :4485-89-6
Formula : C15H14N2
M.W : 222.29
SMILES Code : C1(N=CC=CNC2=CC=CC=C2)=CC=CC=C1
MDL No. :MFCD00051805

Safety of [ 4485-89-6 ]

Application In Synthesis of [ 4485-89-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4485-89-6 ]

[ 4485-89-6 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 80370-42-9 ]
  • [ 4485-89-6 ]
  • 3
  • [ 109-89-7 ]
  • [ 4485-89-6 ]
  • [ 13361-34-7 ]
  • C18H30N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
73.5% [N- (3-ANILINO-ALLYLIDENE)-ANILINE] (4.5 g, 0.02 mol) and cyanoacetic acid 2-ethylhexyl ester (4.2 g, 0.021 mol) are stirred in 10 ml of acetanhydride for 2 hours at [85-90XB0;C.] After removing the excess of acetanhydride in vacuo, the reaction batch is poured onto ice, and the resulting precipitate is filtered off and washed with copious amounts of water. After drying in vacuo at [60XB0;C,] the intermediate product is taken up in 10 ml of dry ethanol, and diethylamine (3.1 g, 0.042 mol) is added. The reaction mixture is stirred for 2 hours at 50- [55XB0;C.] The ethanol and the excess of amine are then distilled off in vacuo. The residue, in a mixture of toluene and acetone (9.5 : 0.5), is subjected to fractionated filtration over silica gel 60 from Merck and isolated. The pure product is dried under a high vacuum at [60XB0;C.] Yield : 4.5 g (73.5 % of theory).
  • 4
  • [ 110-85-0 ]
  • [ 4485-89-6 ]
  • [ 13361-34-7 ]
  • C32H48N4O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% [N- (3-ANILINO-ALLYLIDENE)-ANILINE] (4.5 g, 0.02 mol) and cyanoacetic acid 2-ethylhexyl ester [(4. 2] g, 0.021 mol) are stirred in 10 ml of acetanhydride for 2 hours at [85-90XB0;C.] After removing the excess of acetanhydride in vacuo, the reaction batch is poured onto ice, and the resulting precipitate is filtered off and washed with copious amounts of water. After drying in vacuo at [60XB0;C,] the intermediate product is taken up in 10 mi of dry ethanol, and piperazine (0.8 g, 0.01 mol) is added. After stirring for 2 hours at [50-55XB0;C,] the ethanol is distilled off in vacuo. Subsequent column chromatography over silica gel 60 from Merck using a mixture of toluene and acetone (9: 1) yields the pure product, which is [DRIED IN VACUO] at [60XB0;C.] Yield : 3.9 g (69 % of theory).
  • 5
  • [ 10061-68-4 ]
  • [ 4485-89-6 ]
  • [ 13361-34-7 ]
  • C35H56N4O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% [N- (3-ANILINO-ALLYLIDENE)-ANILINE] (4.5 g, 0.02 mol) and cyanoacetic acid 2-ethylhexyl ester (4.2 g, 0.021 mol) are stirred in 10 ml of acetanhydride for 2 hours at [85-90XB0;C.] After removing the excess of acetanhydride in vacuo, the reaction batch is poured onto ice, and the resulting precipitate is filtered off and washed with copious amounts of water. After drying in vacuo at [60XB0;C,] the intermediate product is taken up in 10 ml of dry ethanol, and diethyl- 1,3-propanediamine (1.3 g, 0.01 mol) is added. The reaction mixture is stirred for 2 hours at [50XB0;C.] The ethanol is then distilled off, and the residue, in a mixture of toluene and acetone (9: 1), is subjected to fractionated filtration over silica gel 60 from Merck and isolated. The pure product is then [DRIED IN VACUO] at [60XB0;C.] Yield : 4.4 g (73 % of theory).
 

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