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Chemical Structure| 45272-19-3 Chemical Structure| 45272-19-3

Structure of 45272-19-3

Chemical Structure| 45272-19-3

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Product Details of [ 45272-19-3 ]

CAS No. :45272-19-3
Formula : C16H30N2O5
M.W : 330.42
SMILES Code : O=C(OC(C)(C)C)CC[C@@H](C(OC(C)(C)C)=O)NC([C@H](C)N)=O

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Application In Synthesis of [ 45272-19-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 45272-19-3 ]

[ 45272-19-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42017-89-0 ]
  • [ 45272-19-3 ]
  • (S)-di-tert-butyl 2-((S)-2-(2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanamido)propanamido)pentanedioate [ No CAS ]
YieldReaction ConditionsOperation in experiment
140 mg With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20℃; To a solution of <strong>[42017-89-0]fenofibric acid</strong> (100 mg, 0.313 mmol) in 5 ml anhydrous dichloromethane was added EDCI (72 mg, 0.375 mmol) at 0 C followed by the addition of HOBt (57 mg, 0.375 mmol). After 10 min. amine compound 2 (1 14 mg, 0.344 mmol) dissolved in 1ml dichloromethane was added to the reaction mixture, followed by the addition of DIPEA (97 mg, 0.751 mmol), and the reaction mixture was stirred at room temperature for 8-10 h. After completion of the reaction by disappearance of the starting material in TLC, water was added to the reaction mixture, and the aqueous layer was extracted with dichloromethane (3x25ml). The combined organic layer was washed with brine solution, dried over anhydrous sodium sulfate, filtered, and evaporated to give a viscous liquid. The crude residue was purified by flash chromatography (Silica gel, 0-50% ethyl acetate/hexane, gradient elution) to afford (S)-di-tert-butyl2-((S)-2-(2-(4- (4-chlorobenzoyl)phenoxy)-2-methylpropanamido) propanamido) pentanedioate (3) (140 654 [M+23].
 

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