[ CAS No. 4542-47-6 ] {[proInfo.proName]}

Name: 4542-47-6|3-(4-Morpholino)propionitrile|95%
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Quality Control of [ 4542-47-6 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 4542-47-6 ]

CAS No. :	4542-47-6	MDL No. :	MFCD00006178
Formula :	C₇H₁₂N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	WXVKGHVDWWXBJX-UHFFFAOYSA-N
M.W :	140.18	Pubchem ID :	78298
Synonyms :

Safety of [ 4542-47-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P210-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501	UN#:	N/A
Hazard Statements:	H227-H302+H312+H332-H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 4542-47-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 4542-47-6 ]
Downstream synthetic route of [ 4542-47-6 ]

[ 4542-47-6 ] Synthesis Path-Upstream 1~3

1
[ 4542-47-6 ]
[ 110-91-8 ]
[ 123-00-2 ]

Yield	Reaction Conditions	Operation in experiment
22%	With sodium tetrahydroborate; hydrogen; nickel dichloride In <i>tert</i>-butyl alcohol at 70℃; for 8 h;	Similarly to the described above, using sodium borohydride (0.6 g, 0.016 mol), 15 mL of tert-butanol, anhydrous nickel(II) chloride (1.0 g, 0.008 mol), and nitrile 1n (14 g, 0.1 mol). The reaction duration was 8h, the temperature was 70°C. Morpholine 9n, content 22 wt percent. Mass spectrum, m/e (I_rel, percent): 88.8 (2) [ M+2], 87.9 (59) [ M+ 1], 86.8 (67) [M], 86.0 (100), 56.9(86), 55.9 (98), 41.9 (28). 3-N-Morpholino-1-aminopropane 2n, content 59 wt percent. Mass spectrum, m/e(I_rel, percent): 145.0 (5) [ M+ 1], 128.0 (1.5), 126.8 (7),113.0 (32), 101.0 (11), 100.0 (100), 86.0 (7), 72.0 (10),70.0 (30), 57.0 (11), 56.0 (35), 42.0 (30).

Reference： [1] Russian Journal of General Chemistry, 2016, vol. 86, # 2, p. 273 - 280[2] Zh. Obshch. Khim., 2016, vol. 86, # 2, p. 245 - 252,8

2
[ 4542-47-6 ]
[ 123-00-2 ]

Reference： [1] Journal of the Indian Chemical Society, 1958, vol. 35, p. 205,208,209
[2] Journal of the American Chemical Society, 1944, vol. 66, p. 725,728
[3] Patent: US2883370, 1954, ,
[4] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 6, p. 675 - 680

3
[ 4542-47-6 ]
[ 123-00-2 ]
[ 18889-29-7 ]

Reference： [1] Journal of the American Chemical Society, 1944, vol. 66, p. 725,728

[ 4542-47-6 ] Synthesis Path-Downstream 1~18

1
[ 110-91-8 ]
[ 110-67-8 ]
[ 4542-47-6 ]

Reference： [1]Patent: US2425693,1944,

2
[ 4542-47-6 ]
[ 58819-72-0 ]
[ 65873-60-1 ]

Reference： [1]European Journal of Medicinal Chemistry,1977,vol. 12,p. 531 - 536

3
[ 4542-47-6 ]
[ 79714-25-3 ]
(Z)-2-(3-Ethoxy-4-pentyloxy-benzyl)-3-morpholin-4-yl-acrylonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium methylate In dimethyl sulfoxide

Reference： [1]Sirichaiwat, Chawanee; Intaraudom, Chakapong; Kamchonwongpaisan, Sumalee; Vanichtanankul, Jarunee; Thebtaranonth, Yodhathai; Yuthavong, Yongyuth [Journal of Medicinal Chemistry, 2004, vol. 47, # 2, p. 345 - 354]

4
[ 4542-47-6 ]
[ 5922-56-5 ]
(Z)-2-(4-Methoxy-3-propoxy-benzyl)-3-morpholin-4-yl-acrylonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium methylate In dimethyl sulfoxide

5
[ 4542-47-6 ]
[ 32024-15-0 ]
[ 113-00-8 ]
[ 83166-73-8 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 1811 - 1815

6
[ 4542-47-6 ]
[ 60186-33-6 ]
C₂₃H₂₆N₂O₃ [ No CAS ]

Reference： [1]Analytical Chemistry,2007,vol. 79,p. 5006 - 5012

7
[ 4542-47-6 ]
[ 102440-39-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: H₂, NH₃ / Raney-Ni / methanol 2: 58 percent / methanol / 0 °C
	Multi-step reaction with 2 steps 1: ethanolic NH₃ / 105 °C / 147102 - 205942 Torr
	Multi-step reaction with 2 steps 1: Raney nickel / 95 °C / 95616 Torr / Hydrogenation

Reference： [1]Kumar, Versha Vinay; Singh, Sudhir K.; Sharma; Bhaduri; Gupta, Suman; Zaidi, Alima; Tiwari, Suman; Katiyar [Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 6, p. 675 - 680]
[2]Whitmore et al. [Journal of the American Chemical Society, 1944, vol. 66, p. 725,728]
[3]Whitmore et al. [Journal of the American Chemical Society, 1944, vol. 66, p. 725,728]

8
[ 4542-47-6 ]
[ 351066-31-4 ]
C₂₃H₂₅BrN₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium methylate In dimethyl sulfoxide at 75℃;

Reference： [1]Location in patent: scheme or table Xu, Li Bao; Sun, Wei; Liu, Hong Ying; Wang, Li Li; Xiao, Jun Hai; Yang, Xiao Hong; Li, Song [Chinese Chemical Letters, 2010, vol. 21, # 11, p. 1318 - 1321]

9
[ 4542-47-6 ]
[ 351066-34-7 ]
C₂₃H₂₆N₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium methylate In dimethyl sulfoxide at 75℃;

10
[ 4542-47-6 ]
[ 32024-15-0 ]
3-morpholino-2-(5-iodo-3,4-dimethoxybenzyl)acrylonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		The general method of Roth et al. [29] was modified. A solution of 6.92 g (54.1 mmol) of 9 in 20 mL of anhydrous DMSO was treated with 0.29 g (5.40 mmol) of sodium methoxide, and heated at 70-72 C. A warm solution of 12.2 g (41.8 mmol) of 11 in 15 mL of DMSO was added to the solution of 9 over 15 min, and stirring was continued at 72 C for 45 min. The crude reaction mixture was cooled in an ice bath, and 40 mL of ice-cold water was added. The mixture was extracted with dichloromethane (3 × 100 mL), and the combined organic layers were washed with saturated NaCl, dried (MgSO4), and concentrated under vacuum to give 3-morpholino-2-(5-iodo-3,4-dimethoxybenzyl)acrylonitrile (12) as dark red oil. This crude material was dissolved in dry ethanol, 6.76 g (52.2 mmol) of aniline hydrochloride was added, and the mixture was refluxed for 1 h. While the mixture was still hot, 9.55 g (100 mmol) of guanidine hydrochloride was added, followed by 9.00 g (167 mmol) of sodium methoxide (Caution. The initial addition must be done very slowly). The reaction mixture was then heated under reflux for 3 h and concentrated under vacuum to one-third volume. The mixture was cooled to 0 C for 30 min, and 40 mL of ice-cold water was added. The resulting crude product was filtered, washed with water and recrystallized twice (4:1 ethanol:water) to give 13 (9.68 g, 60%) as a tan solid, mp 217-218 C. IR: 3467, 3315, 3140, 1638 cm-1; 1H NMR (DMSO-d6, 300 MHz): delta 7.57 (s, 1H), 7.14 (d, 1H, J = 1.8 Hz), 6.98 (d, 1H, J = 1.8 Hz), 6.16 (br s, 2H), 5.77 (br s, 2H), 3.77 (s, 3H), 3.66 (s, 3H), 3.54 (s, 2H); 13C NMR (DMSO-d6, 75 MHz): delta 162.4, 162.1, 156.0, 152.0, 146.3, 138.9, 129.1, 113.8, 105.2, 92.4, 59.8, 55.8, 31.7.
		General procedure: The condensation reactions of halogenated dimethoxy benzaldehydeadducts (2a, 2b, or 2c) and 3-morpholinopropio nitrile (3) wereconducted based on the previously reported procedure.15 Compound 3(11.49 mmol), prepared based on previously reported procedure.20 wasdissolved in DMSO (3.0 mL) and heated to 65 C. Into a preheated solution,a freshly prepared sodium methoxide (4.59 mmol) was slowlyadded and stirred for 45 min at 80 C. Then, a solution of 2 (9.19 mmol)in DMSO (5.0 mL) was added into the heated solution. The reaction wasstirred at 80 C for 16 h. The reaction was quenched with diluted HCl(1:2 of 1M HCl in H2O) and extracted with CH2Cl2. An organic layerwas subsequently washed with water and saturated NaCl solution. Thewashed organic layer was dried over Na2SO4. The solvent was removedunder reduced pressure, affording dark brown viscous liquid. The crudeproduct was partially purified by column chromatography to give ayellow to brown viscous liquid mixture. The mixture was carried on tothe next step.

Reference： [1]European Journal of Medicinal Chemistry,2012,vol. 54,p. 387 - 396
[2]Bioorganic and Medicinal Chemistry,2018,vol. 26,p. 5343 - 5348

11
[ 4542-47-6 ]
[ 443291-33-6 ]
C₁₈H₂₃IN₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 3-Morpholin-4-yl-propionitrile With sodium methylate In dimethyl sulfoxide at 65 - 90℃; Inert atmosphere; Stage #2: 3-iodo-4,5-diethoxybenzaldehyde In dimethyl sulfoxide at 90℃; for 1.08333h; Inert atmosphere;	4.2.3. 5-(3,4-Diethoxy-5-iodobenzyl)pyrimidine-2,4-diamine (15) To a stirred solution of NaOMe (1.69 g, 31.3 mmol, 1.0 equiv) in DMSO (25mL) was added dropwise 3-morpholinopropionitrile 10 (5.25 g, 37.5 mmol, 1.2 equiv) at 65°C. The reaction mixture was heated to 90°C, followed by the addition of a warm solution of 6 (10.0 g, 31.3 mmol) in DMSO (15 mL) over 20 min. Stirring was continued at 90°C for 45 min. The crude reaction mixture was then cooled in an ice bath, poured into ice-cold water, and extracted with CH2Cl2 (3×100 mL). The combined organic extracts were washed with saturated NaCl (1×100 mL), dried (MgSO4), filtered, and concentrated under vacuum to give crude 11 as dark red oil.

Reference： [1]Nammalwar, Baskar; Bourne, Christina R.; Wakeham, Nancy; Bourne, Philip C.; Barrow, Esther W.; Muddala, N. Prasad; Bunce, Richard A.; Berlin, K. Darrell; Barrow, William W. [Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 1, p. 203 - 211]

12
[ 4542-47-6 ]
[ 384857-33-4 ]
C₁₇H₂₁IN₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 3-Morpholin-4-yl-propionitrile With sodium methylate In dimethyl sulfoxide at 65 - 90℃; Inert atmosphere; Stage #2: 4-ethoxy-5-iodo-3-methoxybenzaldehyde In dimethyl sulfoxide at 90℃; for 1.08333h; Inert atmosphere;	General procedure: To a stirred solution of NaOMe (1.69 g, 31.3 mmol, 1.0 equiv) in DMSO (25mL) was added dropwise 3-morpholinopropionitrile 10 (5.25 g, 37.5 mmol, 1.2 equiv) at 65°C. The reaction mixture was heated to 90°C, followed by the addition of a warm solution of 6 (10.0 g, 31.3 mmol) in DMSO (15 mL) over 20 min. Stirring was continued at 90°C for 45 min. The crude reaction mixture was then cooled in an ice bath, poured into ice-cold water, and extracted with CH2Cl2 (3×100 mL). The combined organic extracts were washed with saturated NaCl (1×100 mL), dried (MgSO4), filtered, and concentrated under vacuum to give crude 11 as dark red oil. 4.2.4. 5-(4-Ethoxy-3-iodo-5-methoxybenzyl)pyrimidine-2,4-diamine (16); This compound was prepared as described above for compound 15 using 7 (10.0 g, 32.7 mmol), 10 (5.49 g, 39.2 mmol, 1.2 equiv),and NaOMe (1.77 g, 32.7 mmol, 1.0 equiv) in DMSO (40 mL) to give crude 12 as a dark red oil.

13
[ 4542-47-6 ]
[ 119113-94-9 ]
C₂₂H₂₃IN₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 3-Morpholin-4-yl-propionitrile With sodium methylate In dimethyl sulfoxide at 65 - 90℃; Inert atmosphere; Stage #2: 4-Benzyloxy-3-iodo-5-methoxybenzaldehyde In dimethyl sulfoxide at 90℃; for 1.08333h; Inert atmosphere;	General procedure: To a stirred solution of NaOMe (1.69 g, 31.3 mmol, 1.0 equiv) in DMSO (25mL) was added dropwise 3-morpholinopropionitrile 10 (5.25 g, 37.5 mmol, 1.2 equiv) at 65°C. The reaction mixture was heated to 90°C, followed by the addition of a warm solution of 6 (10.0 g, 31.3 mmol) in DMSO (15 mL) over 20 min. Stirring was continued at 90°C for 45 min. The crude reaction mixture was then cooled in an ice bath, poured into ice-cold water, and extracted with CH2Cl2 (3×100 mL). The combined organic extracts were washed with saturated NaCl (1×100 mL), dried (MgSO4), filtered, and concentrated under vacuum to give crude 11 as dark red oil. 4.2.5. 5-[4-(Benzyloxy)-3-iodo-5-methoxybenzyl]pyrimidine-2,4-diamine (17); This compound was prepared as described above for compound15 using 8 (10.0 g, 27.2 mmol), 10 (4.57 g, 32.6 mmol, 1.2 equiv),and NaOMe (1.47 g, 27.2 mmol, 1.0 equiv) in DMSO (40 mL) to give crude 13 as a dark brown oil.

14
[ 4542-47-6 ]
[ 1676-90-0 ]
[ 108-94-1 ]
[ 100-46-9 ]
C₂₂H₃₀N₂O₄ [ No CAS ]

Reference： [1]PLoS ONE,2015,vol. 10

15
[ 4542-47-6 ]
[ 110-91-8 ]
[ 123-00-2 ]

Yield	Reaction Conditions	Operation in experiment
22%; 59%	With sodium tetrahydroborate; hydrogen; nickel dichloride; In tert-butyl alcohol; at 70℃; under 760.051 Torr; for 8h;	Similarly to the described above, using sodium borohydride (0.6 g, 0.016 mol), 15 mL of tert-butanol, anhydrous nickel(II) chloride (1.0 g, 0.008 mol), and nitrile 1n (14 g, 0.1 mol). The reaction duration was 8h, the temperature was 70C. Morpholine 9n, content 22 wt %. Mass spectrum, m/e (Irel, %): 88.8 (2) [ M+2], 87.9 (59) [ M+ 1], 86.8 (67) [M], 86.0 (100), 56.9(86), 55.9 (98), 41.9 (28). 3-N-Morpholino-1-aminopropane 2n, content 59 wt %. Mass spectrum, m/e(Irel, %): 145.0 (5) [ M+ 1], 128.0 (1.5), 126.8 (7),113.0 (32), 101.0 (11), 100.0 (100), 86.0 (7), 72.0 (10),70.0 (30), 57.0 (11), 56.0 (35), 42.0 (30).

Reference： [1]Russian Journal of General Chemistry,2016,vol. 86,p. 273 - 280
Zh. Obshch. Khim.,2016,vol. 86,p. 245 - 252,8

16
[ 4542-47-6 ]
[ 48152-09-6 ]
C₁₃H₂₈N₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 50% 2: 21.3%	With sodium tetrahydroborate; hydrogen; nickel dichloride In isopropyl alcohol at 70℃; for 14h;	Hydrogenation of 3-N-morpholinopropionitrile 1n. a Similarly to the described above, using sodium borohydride (0.6 g, 0.016 mol), 15 mL of isopropanol, anhydrous nickel(II) chloride (1.0 g, 0.008 mol), and nitrile 1n (14 g, 0.1 mol). The reaction duration was 14 h, the temperature was 70°C. 1,3-Bis-N-morpholinopropane 12n, content 50 wt %. Mass spectrum, m/e (Irel, %): 215 (12) [M+1], 214 (100) [M], 196 (19), 184 (13), 128 (16) [M-C4H8NO], 127 (31), 126 (16), 114 (16) [M-C5H10NO], 112 (77), 100 (72) [C5H10NO], 98 (17), 70 (17). Compound 13n, content 21.3 wt %. Mass spectrum, m/e (Irel, %): 228 (9) [M], 227 (55) [M-1], 208 (13), 196 (19), 139 (16), 128 (20) [M- C4H8NO], 124 (100), 112 (89), 100 (23) [C5H10NO], 70 (10), 43 (4) [C3H7].

Reference： [1]Mokhov; Popov; Shcherbakova [Russian Journal of General Chemistry, 2016, vol. 86, # 2, p. 273 - 280][Zh. Obshch. Khim., 2016, vol. 86, # 2, p. 245 - 252,8]

17
[ 4542-47-6 ]
[ 18268-68-3 ]
C₁₆H₁₉ClN₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 3-Morpholin-4-yl-propionitrile With sodium methylate In dimethyl sulfoxide at 65 - 80℃; for 0.75h; Inert atmosphere; Stage #2: 5-chloroveratraldehyde In dimethyl sulfoxide at 80℃; for 16h; Inert atmosphere;	1 4.1.3. General procedure for cyclization of 2,4-diamino pyrimidine ring(TMP-Cl, TMP-Br, and TMP-I) General procedure: The condensation reactions of halogenated dimethoxy benzaldehydeadducts (2a, 2b, or 2c) and 3-morpholinopropio nitrile (3) wereconducted based on the previously reported procedure.15 Compound 3(11.49 mmol), prepared based on previously reported procedure.20 wasdissolved in DMSO (3.0 mL) and heated to 65 °C. Into a preheated solution,a freshly prepared sodium methoxide (4.59 mmol) was slowlyadded and stirred for 45 min at 80 °C. Then, a solution of 2 (9.19 mmol)in DMSO (5.0 mL) was added into the heated solution. The reaction wasstirred at 80 °C for 16 h. The reaction was quenched with diluted HCl(1:2 of 1M HCl in H2O) and extracted with CH2Cl2. An organic layerwas subsequently washed with water and saturated NaCl solution. Thewashed organic layer was dried over Na2SO4. The solvent was removedunder reduced pressure, affording dark brown viscous liquid. The crudeproduct was partially purified by column chromatography to give ayellow to brown viscous liquid mixture. The mixture was carried on tothe next step.

Reference： [1]Nilchan, Napon; Phetsang, Wanida; Nowwarat, Taechin; Chaturongakul, Soraya; Jiarpinitnun, Chutima [Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 19, p. 5343 - 5348]

18
[ 4542-47-6 ]
[ 6948-30-7 ]
[ 41833-82-3 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 3-Morpholin-4-yl-propionitrile With sodium methylate In dimethyl sulfoxide at 65 - 80℃; for 0.75h; Inert atmosphere; Stage #2: 5-bromoveratralaldehyde In dimethyl sulfoxide at 80℃; for 16h; Inert atmosphere;	2 4.1.3. General procedure for cyclization of 2,4-diamino pyrimidine ring(TMP-Cl, TMP-Br, and TMP-I) General procedure: The condensation reactions of halogenated dimethoxy benzaldehydeadducts (2a, 2b, or 2c) and 3-morpholinopropio nitrile (3) wereconducted based on the previously reported procedure.15 Compound 3(11.49 mmol), prepared based on previously reported procedure.20 wasdissolved in DMSO (3.0 mL) and heated to 65 °C. Into a preheated solution,a freshly prepared sodium methoxide (4.59 mmol) was slowlyadded and stirred for 45 min at 80 °C. Then, a solution of 2 (9.19 mmol)in DMSO (5.0 mL) was added into the heated solution. The reaction wasstirred at 80 °C for 16 h. The reaction was quenched with diluted HCl(1:2 of 1M HCl in H2O) and extracted with CH2Cl2. An organic layerwas subsequently washed with water and saturated NaCl solution. Thewashed organic layer was dried over Na2SO4. The solvent was removedunder reduced pressure, affording dark brown viscous liquid. The crudeproduct was partially purified by column chromatography to give ayellow to brown viscous liquid mixture. The mixture was carried on tothe next step.

Reference： [1]Nilchan, Napon; Phetsang, Wanida; Nowwarat, Taechin; Chaturongakul, Soraya; Jiarpinitnun, Chutima [Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 19, p. 5343 - 5348]

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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 4542-47-6 ] {[proInfo.proName]}

Quality Control of [ 4542-47-6 ]

Related Doc. of [ 4542-47-6 ]

Product Details of [ 4542-47-6 ]

Safety of [ 4542-47-6 ]

Application In Synthesis of [ 4542-47-6 ]

[ 4542-47-6 ] Synthesis Path-Upstream 1~3

[ 4542-47-6 ] Synthesis Path-Downstream 1~18

Related Functional Groups of [ 4542-47-6 ]

Nitriles

Related Parent Nucleus of [ 4542-47-6 ]

Morpholines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 4542-47-6 ]

Related Parent Nucleus of
[ 4542-47-6 ]