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[ CAS No. 455-88-9 ]

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Chemical Structure| 455-88-9
Chemical Structure| 455-88-9
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Product Details of [ 455-88-9 ]

CAS No. :455-88-9 MDL No. :MFCD00007284
Formula : C7H6FNO2 Boiling Point : 223°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :155.13 g/mol Pubchem ID :68001
Synonyms :

Safety of [ 455-88-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302+H312+H332-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 455-88-9 ]

  • Upstream synthesis route of [ 455-88-9 ]
  • Downstream synthetic route of [ 455-88-9 ]

[ 455-88-9 ] Synthesis Path-Upstream   1~26

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Reference: [1] Journal of the Indian Chemical Society, 1944, vol. 21, p. 112,114
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YieldReaction ConditionsOperation in experiment
90% With silver fluoride In toluene at 150℃; for 12 h; Sealed tube To an oven-dried resealable tube equipped with a stir bar was added aryl halide as depicted in FIG. 20 (0.12 mmol), BrettPhos (6.4 mg, 0.012 mmol, 10 mol percent), (COD)Pd(CH2TMS)2 (2.3 mg, 0.006 mmol, 5 mol percent), AgF (23 mg, 0.18 mmol) and toluene (2 mL). The tube was then sealed with a screw-cap and taken out of the glove box, wrapped in aluminum foil and placed into a preheated oil bath at the indicated temperature with adequate stirring. After 12, the tube was removed from the oil bath and allowed to cool to room temperature. 4-Fluorotoluene (13.2 μL, 0.12 mmol, 1 equiv) and dodecane (27.3 μL, 0.12 mmol, 1 equiv) were added as standards. The reaction mixture was filtered through a glass filter and a plug of Celite.(R). to remove all solids. Then, it was analyzed by 19F NMR (282 MHz) for yield and GC for conversion.
Reference: [1] Patent: US2011/15401, 2011, A1, . Location in patent: Page/Page column 17
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 315,316
  • 3
  • [ 95-52-3 ]
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Reference: [1] Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 3952 - 3958
[2] Bulletin des Societes Chimiques Belges, 1960, vol. 69, p. 312 - 322
[3] Journal of Organic Chemistry, 1979, vol. 44, # 14, p. 2556 - 2560
[4] Patent: US4801717, 1989, A,
  • 4
  • [ 7149-70-4 ]
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Reference: [1] Applied Catalysis A: General, 2011, vol. 394, # 1-2, p. 191 - 194
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  • [ 1195931-64-6 ]
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Reference: [1] Science, 2009, vol. 325, # 5948, p. 1661 - 1664
  • 6
  • [ 95-52-3 ]
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  • [ 1427-07-2 ]
Reference: [1] Journal of Organic Chemistry, 1998, vol. 63, # 23, p. 8448 - 8454
  • 7
  • [ 99-99-0 ]
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  • [ 500-11-8 ]
Reference: [1] Journal of Fluorine Chemistry, 1996, vol. 77, # 1, p. 65 - 70
  • 8
  • [ 99-08-1 ]
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  • [ 1427-07-2 ]
  • [ 455-94-7 ]
Reference: [1] Journal of Fluorine Chemistry, 1996, vol. 77, # 1, p. 65 - 70
  • 9
  • [ 95-52-3 ]
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  • [ 769-10-8 ]
Reference: [1] Chemische Berichte, 1929, vol. 62, p. 1804
  • 10
  • [ 95-52-3 ]
  • [ 455-88-9 ]
  • [ 1427-07-2 ]
  • [ 437-86-5 ]
Reference: [1] Russian Journal of General Chemistry, 1996, vol. 66, # 11, p. 1831 - 1836
  • 11
  • [ 95-52-3 ]
  • [ 7697-37-2 ]
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Reference: [1] Journal of the Chemical Society, 1955, p. 4026
  • 12
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  • [ 63878-68-2 ]
Reference: [1] Journal of Fluorine Chemistry, 1996, vol. 77, # 1, p. 65 - 70
  • 13
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  • [ 27996-87-8 ]
Reference: [1] Canadian Journal of Chemistry, 1960, vol. 38, p. 712 - 719
  • 14
  • [ 455-88-9 ]
  • [ 452-67-5 ]
Reference: [1] Bulletin des Societes Chimiques Belges, 1960, vol. 69, p. 312 - 322
  • 15
  • [ 95-52-3 ]
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  • [ 1427-07-2 ]
Reference: [1] Journal of Organic Chemistry, 1998, vol. 63, # 23, p. 8448 - 8454
  • 16
  • [ 99-08-1 ]
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  • [ 1427-07-2 ]
  • [ 455-94-7 ]
Reference: [1] Journal of Fluorine Chemistry, 1996, vol. 77, # 1, p. 65 - 70
  • 17
  • [ 95-52-3 ]
  • [ 455-88-9 ]
  • [ 1427-07-2 ]
  • [ 437-86-5 ]
Reference: [1] Russian Journal of General Chemistry, 1996, vol. 66, # 11, p. 1831 - 1836
  • 18
  • [ 95-52-3 ]
  • [ 7697-37-2 ]
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Reference: [1] Journal of the Chemical Society, 1955, p. 4026
  • 19
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  • [ 769-10-8 ]
Reference: [1] Chemische Berichte, 1929, vol. 62, p. 1804
  • 20
  • [ 95-52-3 ]
  • [ 7697-37-2 ]
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  • [ 1427-07-2 ]
  • [ 769-10-8 ]
Reference: [1] Journal of the Chemical Society, 1955, p. 4026
  • 21
  • [ 455-88-9 ]
  • [ 452-68-6 ]
Reference: [1] Journal of the Indian Chemical Society, 1944, vol. 21, p. 112,114
  • 22
  • [ 95-52-3 ]
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  • [ 1427-07-2 ]
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Reference: [1] Russian Journal of General Chemistry, 1996, vol. 66, # 11, p. 1831 - 1836
  • 23
  • [ 455-88-9 ]
  • [ 452-69-7 ]
Reference: [1] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[2] Canadian Journal of Chemistry, 1958, vol. 36, p. 238
[3] Journal of the Indian Chemical Society, 1944, vol. 21, p. 112,114
[4] Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1985, vol. 39, # 3, p. 213 - 217
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 23, p. 6492 - 6499
  • 24
  • [ 125620-28-2 ]
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  • [ 452-69-7 ]
Reference: [1] Patent: US6162927, 2000, A,
  • 25
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  • [ 97389-11-2 ]
Reference: [1] Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1985, vol. 39, # 3, p. 213 - 217
  • 26
  • [ 455-88-9 ]
  • [ 112900-82-0 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 4, p. 353 - 360
[2] Patent: WO2015/38417, 2015, A1,
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5099 - 5119
[4] Patent: WO2005/105761, 2005, A1,
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