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Chemical Structure| 460-39-9 Chemical Structure| 460-39-9

Structure of 460-39-9

Chemical Structure| 460-39-9

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Product Details of [ 460-39-9 ]

CAS No. :460-39-9
Formula : C3H6F3N
M.W : 113.08
SMILES Code : NCCC(F)(F)F
MDL No. :MFCD01694854

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Application In Synthesis of [ 460-39-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 460-39-9 ]

[ 460-39-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 460-39-9 ]
  • [ 161957-56-8 ]
  • 3-bromo-2-fluoro-N-(3,3,3-trifluoro-propyl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 4h; A solution of 3-bromo-2-fluoro-benzoic acid (0.500 g, 2.28 mmol), HATU (0.868 g, 2.28 mmol), 3,3,3-trifluoropropylamine (0.297 g, 2.63 mmol) and DIPEA (1 .19 mL, 6.85 mmol) in DCM (10 mL) was stirred for 4 h. The mixture was diluted with DCM and the organic phase washed with aqueous NaHC03 and dried by passage through a phase separation cartridge. Concentration to dryness gave the crude product (1 .58g, quantative), used without further purification. LC-MS m/z 315 (M + H) +, 1 .33 (ret. time).
 

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[ 460-39-9 ]

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