Home Cart Sign in  
Chemical Structure| 46050-30-0 Chemical Structure| 46050-30-0

Structure of 46050-30-0

Chemical Structure| 46050-30-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 46050-30-0 ]

CAS No. :46050-30-0
Formula : C9H12N2O
M.W : 164.20
SMILES Code : O=C(N)CC(N)C1=CC=CC=C1
MDL No. :MFCD06216612

Safety of [ 46050-30-0 ]

Application In Synthesis of [ 46050-30-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 46050-30-0 ]

[ 46050-30-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 22838-46-6 ]
  • [ 46050-30-0 ]
YieldReaction ConditionsOperation in experiment
1.195 g With ammonium hydroxide; In water; at 20℃; The procedure for the synthesis of 3a is described as a representative one. Thionyl chloride (1.45mL, 20mmol) was dropwise added to a mixture of 3-amino-3-phenylpropanoic acid (1.65g, 10mmol) and dry methanol (15mL) in a 2-neck round bottom flask connected with a condenser. After being refluxed overnight at 70C, the mixture was cooled to ambient temperature, and methanol was removed by evaporation. The salt precipitate was washed with ethyl acetate and then dissolved in aqueous ammonium hydroxide (20mL). The resulting mixture was stirred at room temperature overnight and extracted with CH2Cl2. The organic layer was dried over Na2SO4 and evaporated under reduced pressure to obtain 3a as a white solid (1.195g, 7.28mmol, 73%): mp 99-101C (lit.20 mp 110.1C); the data of 1H and 13C NMR were in good agreement with the literature data.20 Compound 3b: mp 118-122C; 1H NMR (300MHz, CDCl3, ppm): delta 1.8 (2H, br s, NH2), 2.51-2.53 (2H, m, CH2CH), 4.36-4.40 (1H, m, CHNH2), 5.7 (1H, br s, CONH2), 6.7 (1H, br s, CONH2), 7.00-7.07 (2H, m, C6H4), 7.27-7.34 (2H, m, C6H4). 13C NMR (75MHz, CDCl3, ppm): delta 45.1, 52.2, 115.6(d), 127.5(d), 140.7(d), 160.4, 163.7, 173.5. 3c: mp 123-126C; the data of 1H and 13C NMR were in good agreement with the literature data.20 3d: mp 102-105C; the data of 1H and 13C NMR were in good agreement with the literature data.20
  • 2
  • [ 46050-30-0 ]
  • [ 56844-12-3 ]
  • 3-((6-bromothieno[2,3-d]pyrimidin-4-yl)amino)-3-phenylpropanamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
84% With sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 0.166667h;Sealed tube; Microwave irradiation; 6-Bromo-4-chlorothieno[2,3-d]pyrimidine[9] (153 mg, 0.613 mmol) wasmixed with 3-amino-3-phenylpropanamide (105 mg, 0.637 mmol), NaHCO3(101 mg, 1.20 mmol) and DMF (4 mL). The reaction mixture was heated in asealed tube with a microwave at 120 W for 10 minutes. The mixture was thencooled to ambient temperature, concentrated in vacuo, diluted with water andextracted with EtOAc (2 × 25 mL). The combined organic phases were washed with saturatedaq. NaCl solution (15 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo.The crude material was purified by silica-gel column chromatography (EtOAc, Rf = 0.18). Thisgave 191 mg (0.506 mmol, 84%) of the target compound as a white solid.
  • 3
  • [ 46050-30-0 ]
  • [ 56844-12-3 ]
  • 3-((6-(4-(hydroxymethyl)phenyl)thieno[2,3-d]pyrimidin-4-yl)amino)-3-phenylpropanamide [ No CAS ]
 

Historical Records