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Chemical Structure| 4620-67-1 Chemical Structure| 4620-67-1

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Chemical Structure| 4620-67-1

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Product Details of [ 4620-67-1 ]

CAS No. :4620-67-1
Formula : C11H11ClO
M.W : 194.66
SMILES Code : O=C(Cl)C1(C2=CC=CC=C2)CCC1
MDL No. :MFCD09903688

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Application In Synthesis of [ 4620-67-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4620-67-1 ]

[ 4620-67-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 13220-33-2 ]
  • [ 4620-67-1 ]
  • 1-Methyl-3-pyrrolidinyl 1-phenylcyclobutanecarboxylate Hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 62 1-Methyl-3-pyrrolidinyl 1-phenylcyclobutanecarboxylate Hydrochloride The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutanecarbonyl chloride with <strong>[13220-33-2]1-methyl-3-hydroxypyrrolidine</strong> at 80° C. for 17 h. The yield was 1.1 g (67percent); mp 153-155° C.; 1 H NMR (DMSO-d6, 1percent TFA) delta 1.83 (m, 1.5H), 1.96 (m, 1.5H), 2.17 (m, 0.5H), 2.38-2.51 (m, 2.5H), 2.64 (t, 1.5H), 2.73-2.92 (m, 4H), 2.97 (m, 0.5H), 3.06 (m, 0.5H), 3.32 (m, 0.5H), 3.54 (m, 1.5H), 3.76 (m, 0.5H), 5.26 (m, 1H), 7.23-7.39 (m, 5H). Anal. (C16 H21 NO2.HCl) C, H, N. The compound exists in two forms in DMSO-TFA solution.
  • 2
  • [ 20845-34-5 ]
  • [ 4620-67-1 ]
  • [ 202736-60-5 ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 57 (1-Methyl-2-piperidino)methyl 1-phenylcyclobutanecarboxylate Hydrochloride The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutanecarbonyl chloride with 1-methyl-2-piperidinemethanol at 80° C. for 17 h. The yield was 1.1 g (61percent); mp 159-162° C.; 1 H NMR (DMSO-d6, 1percent TFA) delta 1.42 (m, 1H), 1.54 (m, 1H), 1.60-1.87 (m, 5H), 1.97 (m, 1H), 2.42-2.55 (m, 5H), 2.81 (m, 2H), 2.95 (m, 0.8H), 3.11 (m, 0.4H), 3.21-3.35 (m, 1.6H), 3.53 (m, 0.2H), 4.21-4.39 (m, 2H), 7.26 (m, 1H), 7.31-7.38 (m, 4H). Anal. (C18 H25 NO2.HCl) H, N; C: calcd, 66.8; found, 67.5. The compound exists in two forms in DMSO-TFA solution.
  • 3
  • [ 7583-53-1 ]
  • [ 4620-67-1 ]
  • [ 202736-61-6 ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 58 (1-Methyl-3-piperidino)methyl 1-phenylcyclobutanecarboxylate Hydrochloride The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-phenylcyclobutanecarbonyl chloride with 1-methyl-3-piperidinemethanol at 80° C. for 18 h. The yield was 1.4 g (77percent); mp 126-128° C.; 1 H NMR (D2 O) delta 1.15 (m, 1H), 1.67-1.81 (m, 2H), 1.97 (m, 2H), 2.05-2.19 (m, 2H), 2.42 (t, 1H), 2.64 (m, 2H), 2.73 (m, 1H), 2.80 (s, 3H), 2.87 (m, 2H), 3.17 (d, 1H), 3.49 (d, 1H), 4.09 (q, 1H), 4.17 (q, 1H), 7.44 (t, 1H), 7.49 (d, 2H), 7.54 (t, 2H). Anal. (C18 H25 NO2.HCl) C, H, N.
 

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