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Chemical Structure| 46232-97-7 Chemical Structure| 46232-97-7

Structure of 46232-97-7

Chemical Structure| 46232-97-7

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Product Details of [ 46232-97-7 ]

CAS No. :46232-97-7
Formula : C9H9BrO3
M.W : 245.07
SMILES Code : C[C@@H](OC1=CC=C(Br)C=C1)C(O)=O
MDL No. :MFCD29966370

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Application In Synthesis of [ 46232-97-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 46232-97-7 ]

[ 46232-97-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1129-46-0 ]
  • [ 46232-97-7 ]
YieldReaction ConditionsOperation in experiment
95.1% With N-Bromosuccinimide; In water; N,N-dimethyl-formamide; at 20 - 30℃; for 8h; Dissolve 2-phenoxypropionic acid 838 (0.51 ^ 1, 1.069) in water, add 0.6g (0.0075mol,0 · 015eq), NBS 102g (0.575mol, 1.15eq) was added at 20-30C. After the addition was completed, the reaction was performed at 20-30C for 8h.HPLC monitors that 2-phenoxypropionic acid is less than or equal to 2%. Cool down, adjust pH <1 with 31% hydrochloric acid, separate layers, and cool the water phase toBelow 10C, stir for 30 minutes to crystallize, suction filter to obtain 116.5g of 2- (4-bromophenoxy) propionic acid, yield 95.1%, purity98.7%.
  • 2
  • [ 46232-97-7 ]
  • [ 94050-90-5 ]
YieldReaction ConditionsOperation in experiment
98% With water; at 150 - 160℃; under 75.0075 - 150.015 Torr;Alkaline conditions; Autoclave; Inert atmosphere; The 2- (4-bromophenoxy) propionic acid 122.5g (0.5mol, 1.0eq), 30% liquid alkali 67g (4.0eq), gamma-alumina supported copper chloride catalyst 6.2g (0.05eq) , 200g of water was put into the autoclave, nitrogen was replaced three times, and the equipment was sealed.The temperature was raised to 150-160 C with stirring, the reaction pressure was controlled at 0.1-0.2 bar, and the reaction was completed when HPLC monitored 2- (4-halophenoxy) propionic acid ?0.5%.Reduce the temperature, replace with nitrogen three times, transfer the reaction solution to the acidification kettle, adjust the pH
 

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