[ CAS No. 1129-46-0 ]

Name: 1129-46-0|(R)-2-Phenoxypropanoic acid|98%
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Quality Control of [ 1129-46-0 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 1129-46-0 ]

CAS No. :	1129-46-0	MDL No. :	MFCD04038077
Formula :	C₉H₁₀O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	SXERGJJQSKIUIC-SSDOTTSWSA-N
M.W :	166.17	Pubchem ID :	643326
Synonyms :

Safety of [ 1129-46-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1129-46-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1129-46-0 ]

[ 1129-46-0 ] Synthesis Path-Downstream 1~69

1
[ 1129-46-0 ]
[ 32403-66-0 ]

Reference： [1]Arkiv foer Kemi,1953,vol. 6,p. 365,370

2
[ 551-16-6 ]
[ 1129-46-0 ]
[ 34378-72-8 ]

Reference： [1]Journal of the American Chemical Society,1960,vol. 82,p. 3934 - 3938

3
[ 1004-84-8 ]
[ 1129-46-0 ]
(1R,6S,7S)-7-<<((R)-1-phenoxyethyl)carbonyl>oxy>-9-methylenebicyclo<4.3.0>nonane [ No CAS ]
(1S,6R,7R)-7-<<((R)-1-phenoxyethyl)carbonyl>oxy>-9-methylenebicyclo<4.3.0>nonane [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1992,vol. 57,p. 6579 - 6587
[2]Journal of Organic Chemistry,1992,vol. 57,p. 6579 - 6587

4
[ 940-31-8 ]
[ 1129-46-0 ]
[ 87860-35-3 ]

Reference： [1]Agricultural and Biological Chemistry,1984,vol. 48,p. 1373 - 1374

5
[ 42412-84-0 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Tetrahedron Asymmetry,1991,vol. 2,p. 39 - 42

6
[ 2065-24-9 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Tetrahedron Asymmetry,1991,vol. 2,p. 39 - 42
[2]Tetrahedron Asymmetry,1991,vol. 2,p. 39 - 42
[3]Canadian Journal of Chemistry,1988,vol. 66,p. 1219 - 1222
[4]Recueil des Travaux Chimiques des Pays-Bas,1992,vol. 111,p. 490 - 495

7
[ 2065-24-9 ]
[ 1129-46-0 ]
[ 1912-23-8 ]
[ 115880-50-7 ]
[ 115880-48-3 ]

Reference： [1]Tetrahedron Letters,1987,vol. 28,p. 4661 - 4664
[2]Tetrahedron Letters,1987,vol. 28,p. 4661 - 4664

8
[ 1129-46-0 ]
[ 147851-69-2 ]

Yield	Reaction Conditions	Operation in experiment
99%	With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20℃; for 6h;	Oxalyl chloride (1.09 mL, 12.5 mmol) was added to a solution of acid (R)-5 (0.83 g, 5 mmol) and DMF (5 μL) in CH2Cl2 (20 mL). The reaction mixture was stirred at room temperature for 6 h, and then evaporated to dryness under reduced pressure. The residue was dried over P2O5 in vacuo to afford 0.92 g (99%) of compound (R)-2a as a yellowish oil, which had an unpleasant odor. Anal. Calcd for C9H9ClO2: C, 58.55; H, 4.91. Found: C, 58.78; H, 5.07. 1H NMR spectrum was identical to that published for racemic chloride 2a. 5

Reference： [1]Tetrahedron Asymmetry,2016,vol. 27,p. 1231 - 1237
[2]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499

9
[ 76671-56-2 ]
[ 1129-46-0 ]

Yield	Reaction Conditions	Operation in experiment
89%	With sodium hydroxide; In ethanol; at 4 - 20℃; for 24h;	At first, 2 M NaOH (5.2 mL, 10.4 mmol) was added dropwise to a solution of compound (R)-4 (1.01 g, 5.2 mmol) in ethanol (20 mL) with stirring at 4 C. The reaction mixture was stirred at room temperature for 24 h, and then evaporated to dryness under reduced pressure. The residue was dissolved in water (40 mL), washed with ethyl ether (2 * 10 mL), acidified with 4 M HCl to pH 1-2 and extracted with ethyl ether (4 * 20 mL). The organic layers were washed with saturated aqueous NaCl (2 * 40 mL), dried over MgSO4, and evaporated to dryness under reduced pressure. The residue was recrystallized from hexane to yield 0.77 g (89%) of compound (R)-5 as a colorless solid, mp 86-88 C (hexane) (lit. 85-87 C, 12 83 C 13 ); [α]D20 = +16.2 (c 0.6, CHCl3) {lit. 13 [α]D20 = +19 (c 1.0, CHCl3)}. HPLC (Chiralpak AD, n-hexane-iPrOH-TFA 20:1:0.02): 95.6% ee. Anal. Calcd for C9H10O3: C, 65.05; H, 6.06. Found: C, 64.95; H, 6.24. 1H and 13C NMR spectra were identical to those published for (S)-5.14

Reference： [1]Journal of the American Chemical Society,2007,vol. 129,p. 12616 - 12617
[2]Tetrahedron Asymmetry,2016,vol. 27,p. 1231 - 1237
[3]Journal of Organic Chemistry,1992,vol. 57,p. 6579 - 6587
[4]Il Farmaco,1993,vol. 48,p. 1401 - 1416

10
[ 54656-96-1 ]
[ 446878-78-0 ]
[ 1129-46-0 ]
[ 1912-23-8 ]
[ 94559-16-7 ]
[ 94559-15-6 ]

Reference： [1]Chemische Berichte,1984,vol. 117,p. 3457 - 3462
[2]Chemische Berichte,1984,vol. 117,p. 3457 - 3462
[3]Chemische Berichte,1984,vol. 117,p. 3457 - 3462

11
[ 115880-50-7 ]
[ 1129-46-0 ]

Reference： [1]Synthetic Communications,2009,vol. 39,p. 3459 - 3470
[2]Il Farmaco,1993,vol. 48,p. 1401 - 1416

12
[ 1129-46-0 ]
[ 89209-34-7 ]
[ 91712-57-1 ]
[ 89255-52-7 ]

Reference： [1]Journal of the American Chemical Society,1984,vol. 106,p. 5997

13
[ 163104-06-1 ]
[ 1129-46-0 ]
[ 1912-23-8 ]
[ 163104-05-0 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516

14
(R)-2-Phenoxy-propionic acid (1S,2S,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl ester [ No CAS ]
[ 1129-46-0 ]
[ 1912-23-8 ]
[ 163104-05-0 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516

15
(R)-2-Phenoxy-propionic acid (1S,2S,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-bicyclo[3.1.0]hex-2-yl ester [ No CAS ]
[ 1129-46-0 ]
[ 163104-05-0 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516

16
[ 940-31-8 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1995,p. 301 - 302
[2]Russian Chemical Bulletin,2021,vol. 70,p. 900 - 907
Izv. Akad. Nauk, Ser. Khim.,2021,p. 900 - 907
[3]Chirality,2022

17
[ 513-49-5 ]
[ 1129-46-0 ]
(R)-N-((S)-sec-Butyl)-2-phenoxy-propionamide [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7285 - 7290

18
[ 13250-12-9 ]
[ 1129-46-0 ]
(R)-N-((R)-sec-Butyl)-2-phenoxy-propionamide [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7285 - 7290

19
D-Valine methyl ester [ No CAS ]
[ 1129-46-0 ]
(R)-3-Methyl-2-((R)-2-phenoxy-propionylamino)-butyric acid methyl ester [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7285 - 7290

20
[ 4070-48-8 ]
[ 1129-46-0 ]
(S)-3-Methyl-2-((R)-2-phenoxy-propionylamino)-butyric acid methyl ester [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7285 - 7290

21
[ 2627-86-3 ]
[ 1129-46-0 ]
[ 184178-55-0 ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7285 - 7290

22
[ 3886-69-9 ]
[ 1129-46-0 ]
(R)-N-(1-phenylethyl)-(R)-2-phenoxypropionamide [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1996,vol. 61,p. 7285 - 7290

23
[ 184178-55-0 ]
[ 1129-46-0 ]

Reference： [1]Tetrahedron Letters,1999,vol. 40,p. 2307 - 2310

24
[ 1129-46-0 ]
[ 94050-90-5 ]

Reference： [1]Pesticide Science,1996,vol. 46,p. 33 - 35

26
inactive form [ No CAS ]
[ 1129-46-0 ]

Reference： [1]Bulletin de la Societe Chimique de France,1922,vol. <4> 31,p. 990
Bulletin de la Societe Chimique de France,1923,vol. <4> 33,p. 459

27
[ 1129-46-0 ]
/PBMZE₀₁₇-1320/ [ No CAS ]
(S)-2-Phenoxy-propionic acid 3,8,13-triethoxy-7,12-bis-((R)-2-phenoxy-propionyloxy)-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-yl ester [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1985,vol. 107,p. 1299

28
n-butyl 2-phenoxypropionate [ No CAS ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Tetrahedron Asymmetry,2005,vol. 16,p. 3698 - 3702
[2]Journal of the Chemical Society. Perkin Transactions 1 (2001),2001,p. 1386 - 1390
[3]Bulletin of the Chemical Society of Japan,2008,vol. 81,p. 617 - 622

29
[ 908094-01-9 ]
[ 1129-46-0 ]
[ 115880-50-7 ]

Reference： [1]Journal of Organic Chemistry,2003,vol. 68,p. 7234 - 7242
[2]Organic letters,2002,vol. 4,p. 371 - 373

30
[ 940-31-8 ]
[ 1129-46-0 ]

Reference： [1]Journal of Organic Chemistry,2003,vol. 68,p. 7234 - 7242
[2]Organic letters,2002,vol. 4,p. 371 - 373
[3]Tetrahedron Letters,1999,vol. 40,p. 2307 - 2310

31
[ 1129-46-0 ]
[ 474809-21-7 ]
[2-(2-phenoxy-propionylamino)-pyridin-4-ylmethyl]-carbamic acid tert-butyl ester [ No CAS ]

Reference： [1]Organic Letters,2002,vol. 4,p. 3423 - 3426

32
[ 1129-46-0 ]
[ 106-50-3 ]
N-(4-amino-phenyl)-2-phenoxy-propionamide [ No CAS ]

Reference： [1]Organic Letters,2002,vol. 4,p. 3423 - 3426

33
[ 940-31-8 ]
[ 71-36-3 ]
[ 1129-46-0 ]
[ 1912-23-8 ]
(R)-2-Phenoxy-propionic acid butyl ester [ No CAS ]
(S)-2-Phenoxy-propionic acid butyl ester [ No CAS ]

Reference： [1]Bulletin of the Chemical Society of Japan,2003,vol. 76,p. 399 - 403

34
[ 57057-80-4 ]
[ 108-95-2 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Acta Crystallographica Section B: Structural Science,2003,vol. 59,p. 132 - 140

35
[ 1129-46-0 ]
[ 917-54-4 ]
[ 189300-43-4 ]

Reference： [1]Tetrahedron,2004,vol. 60,p. 449 - 457

36
[ 32644-15-8 ]
[ 108-95-2 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Organic Letters,2002,vol. 4,p. 3423 - 3426

37
[ 10009-70-8 ]
[ 108-95-2 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Organic Letters,2002,vol. 4,p. 3423 - 3426

38
3-(2-phenoxy-propionyl)-4-phenyl-oxazolidin-2-one [ No CAS ]
[ 1129-46-0 ]

Reference： [1]Tetrahedron Asymmetry,2007,vol. 18,p. 476 - 482

39
N,N-diisopropyl-3-[2-hydroxy-5-(2-hydroxyethyl)phenyl]-3-phenylpropanamine [ No CAS ]
[ 1129-46-0 ]
(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(2-hydroxyethyl)phenol (R)-2-phenoxypropionic acid salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
37%	In ethyl acetate; at 80℃; for 48h;	(S)-2-Phenoxypropionic acid (3.4Og, 20.5 mmol, 1 equiv) was added to a solution of 2-[3- (diisopropylamino)-l-phenylpropyl]-4-(2-hydroxyethyl)phenol (Example 9, 7.28g, 20.5 mmol, 1 equiv) in ethyl acetate. The mixture was heated at 80 0C for 2 days, upon which the mixture was cooled to room temperature, filtered and washed with ethyl acetate and dried in vacuo at 50 0C overnight to give the title compound as a white solid (3.9g, 7.48 mmol, 37% yield, 94% ee).

Reference： [1]Patent: WO2007/138440,2007,A1 .Location in patent: Page/Page column 19-20

40
[ 1129-46-0 ]
[ 664374-43-0 ]

Reference： [1]Tetrahedron,2004,vol. 60,p. 449 - 457

41
[ 1129-46-0 ]
N-(4-aminomethyl-pyridin-2-yl)-2-phenoxy-propionamide [ No CAS ]

Reference： [1]Organic Letters,2002,vol. 4,p. 3423 - 3426

42
2-Phenoxy-propionic acid 2,2,2-trifluoro-ethyl ester [ No CAS ]
[ 1129-46-0 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516
[2]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516
[3]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516

43
[ 161969-67-1 ]
[ 1129-46-0 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516

44
[ 161969-69-3 ]
[ 1129-46-0 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516
[2]Journal of the Chemical Society. Perkin transactions I,1994,p. 1509 - 1516

45
[ 100-67-4 ]
copper powder [ No CAS ]
[ 1129-46-0 ]

Reference： [1]Il Farmaco,1993,vol. 48,p. 1401 - 1416
[2]Il Farmaco,1993,vol. 48,p. 1401 - 1416

46
[ 1129-46-0 ]
(1S,2R,5S)-menthyl (R)-2-phenoxypropionate [ No CAS ]

Reference： [1]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499

47
[ 1129-46-0 ]
(1R,2S,5R)-menthyl (R)-2-phenoxypropionate [ No CAS ]

Reference： [1]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499
[2]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499

48
[ 1129-46-0 ]
(S)-1-phenylethyl (R)-2-phenoxypropionate [ No CAS ]

Reference： [1]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499

49
[ 1129-46-0 ]
(R)-1-phenylethyl (R)-2-phenoxypropionate [ No CAS ]

Reference： [1]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499

50
[ 1129-46-0 ]
(S)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl (R)-2-phenoxypropionate [ No CAS ]

Reference： [1]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499
[2]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499

51
[ 1129-46-0 ]
(R)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl (R)-2-phenoxypropionate [ No CAS ]

Reference： [1]Acta Chemica Scandinavica,1993,vol. 47,p. 492 - 499

52
[ 1129-46-0 ]
[ 4169-04-4 ]

Reference： [1]Journal of the American Chemical Society,1985,vol. 107,p. 1299
[2]Journal of the American Chemical Society,1985,vol. 107,p. 1299

53
[ 108-95-2 ]
phosphorous oxychloride [ No CAS ]
[ 1129-46-0 ]

Reference： [1]Journal of Organic Chemistry,1992,vol. 57,p. 6579 - 6587

54
[ 62784-66-1 ]
[ 446878-78-0 ]
[ 1213744-22-9 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Advanced Synthesis and Catalysis,2009,vol. 351,p. 2301 - 2304

55
[ 16929-35-4 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Journal of the American Chemical Society,2010,vol. 132,p. 1172 - 1179

56
[ 940-31-8 ]
[ 62784-66-1 ]
[ 1213744-22-9 ]
[ 1345458-52-7 ]
[ 1129-46-0 ]
[ 1912-23-8 ]

Reference： [1]Chemistry - A European Journal,2011,vol. 17,p. 11296 - 11304
[2]Heterocycles,2012,vol. 86,p. 1227 - 1252

57
[ 116435-79-1 ]
[ 1129-46-0 ]

Reference： [1]Organic Letters,2012,vol. 14,p. 194 - 197

58
[ 1129-46-0 ]
3-(3-tolyl)-1H-1,2,4-triazol-5-amine [ No CAS ]
[ 1391916-84-9 ]

Reference： [1]ACS Medicinal Chemistry Letters,2012,vol. 3,p. 715 - 720

59
[ 1402665-69-3 ]
[ 1129-46-0 ]
[ 1419334-50-1 ]

Reference： [1]Organic and Biomolecular Chemistry,2012,vol. 10,p. 8051 - 8054

60
[ 1402665-70-6 ]
[ 1129-46-0 ]
[ 1419334-63-6 ]

Reference： [1]Organic and Biomolecular Chemistry,2012,vol. 10,p. 8051 - 8054

61
[ 2065-24-9 ]
[ 1129-46-0 ]
[ 115880-48-3 ]

Reference： [1]Bioorganic Chemistry,2016,vol. 65,p. 1 - 8

62
[ 82419-33-8 ]
[ 147851-69-2 ]
7,8-difluoro-3,4-dihydro-3-methyl-N-(2′-phenoxypropionyl)-2H-[1,4]benzoxazine [ No CAS ]
[ 1129-46-0 ]