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Chemical Structure| 470482-41-8 Chemical Structure| 470482-41-8
Chemical Structure| 470482-41-8

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CAS No. :470482-41-8
Formula : C11H16F3NO4
M.W : 283.24
SMILES Code : CC(C)(C)OC(=O)N1C[C@H](C[C@H]1C(O)=O)C(F)(F)F
MDL No. :MFCD08460520
InChI Key :OHIYKPXMNWXZQH-BQBZGAKWSA-N
Pubchem ID :11426084

Safety

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 470482-41-8 ]

[ 470482-41-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 89466-16-0 ]
  • [ 470482-41-8 ]
  • (2S,4S)-tert-butyl 2-((6-bromo-3-methylpyridin-2-yl)carbamoyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
57% With pyridine; trichlorophosphate; In dichloromethane; at 0℃; for 0.5h; To a solution of compound 223-Si (50mg, 0.18 mmol ) and <strong>[89466-16-0]6-bromo-3-methylpyridin-2-amine</strong> (33.3 mg, 0.18 mmol) in DCM (3 mL)was added pyridine (71.1 mg, 0.90 mmol) at 0 C followed by the dropwise addition of POC13(27.54 mg, 0.18 mmol). The reaction mixture was stirred at 0 C for 30 minutes. The reactionmixture was quenched with ice-cooled water and extracted with DCM twice. The combined organic phases were washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated to dryness. The residue was purified by silica gel column (eluted with DCM / MeOH= 50 / 1) to afford compound 223-5i2 (45 mg, 57.0%) as a white solid. LC/MS (ESI) m/z: 452/454 (M+H)t
 

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