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Chemical Structure| 4731-34-4 Chemical Structure| 4731-34-4

Structure of 4731-34-4

Chemical Structure| 4731-34-4

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Product Details of [ 4731-34-4 ]

CAS No. :4731-34-4
Formula : C14H14O
M.W : 198.26
SMILES Code : CC1=CC=CC=C1OC2=CC=CC=C2C

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Application In Synthesis of [ 4731-34-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4731-34-4 ]

[ 4731-34-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 615-37-2 ]
  • [ 95-48-7 ]
  • [ 4731-34-4 ]
YieldReaction ConditionsOperation in experiment
98% With caesium carbonate;copper(I) oxide; trans-N,N'-bis(pyridin-2-ylmethylene)cyclohexane-1,2-diamine; In acetonitrile; at 110℃; for 35h;activated 3 A molecular sieve (KnNa12-n[(AlO2)12(SiO2)12]);Conversion of starting material; Example 3.10 [0926] Preparation of bis(o-tolyl) Ether [0927] Example 3.1 was repeated, replacing the phenol with 206 ?l of o-cresol (2 mmoles) and the iodobenzene with 383 ?l of 2-iodotoluene (3 mmoles), the acetonitrile with DMF, and with the nucleophile and the arylation agent being added at the same time as the solvent. [0928] The reaction time was taken to 35 h and the temperature was 110 C. [0929] The degree of transformation and the selectivity for bis(o-tolyl) ether were 100%. [0930] The oily residue obtained after treatment purified by silica gel chromatography (eluent: hexane). [0931] 389 mg of a colourless oil was obtained, which corresponded to a yield of 98%. [0932] The compound obtained had the following formula: [CHEMMOL-00079] [0933] The characteristics were as follows: [0934] 1H NMR/CDCl3: ? 7.32 (m, 2H, H2,11), 7.04-7.25 (m, 4H, H3,4,9,10), 6.81 (m, 2H, H5,8), 2.38 (s, 6H, H13,14); [0935] 13C NMR/CDCl3: ? 155.35 (C6 and C7), 131.39 (C4 and C9), 128.90 (C1 and C12), 127.09 (C2 and C11), 123.11 (C3 and C10), 117.74 (C5 and C8), 16.25 (C13 and C14); [0936] GC/MS:Rt=16.10 min, M/Z=198, purity=100%; [0937] Rf: 0.40 (eluent: hexane).
 

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