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Chemical Structure| 474707-20-5 Chemical Structure| 474707-20-5

Structure of 474707-20-5

Chemical Structure| 474707-20-5

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Product Details of [ 474707-20-5 ]

CAS No. :474707-20-5
Formula : C13H13BrN2O
M.W : 293.16
SMILES Code : BrC1=CC=C2N=CC=C(N3CCOCC3)C2=C1
MDL No. :MFCD20483952

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 474707-20-5 ]

[ 474707-20-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 474707-20-5 ]
  • [ 1083326-75-3 ]
  • [ 1201844-29-2 ]
YieldReaction ConditionsOperation in experiment
76.4% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100℃; for 5h;Inert atmosphere; 6-Bromo-4-morpholinoquinoline (105 mg, 0.36 mmol), <strong>[1083326-75-3]N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide</strong> (141 mg, 0.43 mmol, 1.2 eq) and 2N aqueous potassium carbonate solution (0.54 mL, 1.08 mmol, 3.0 eq) In dioxane (4 mL) was degassed and then [l, l & ' -bis (diphenylphosphino) ferrocene] dichloropalladium (13 mg, 0.018 mmol, 0.05 eq) was added. The resulting reaction mixture was degassed and backfilled with argon (three cycles) Followed by stirring at 100 C for 5 hours in an argon atmosphere. The reaction mixture was cooled to room temperature, diluted with (30 mL) of water and extracted with ethyl acetate (30 mL x 3). The combined organic layers were washed with brine (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash column chromatography (silica gel, dichloromethane / methanol = 60: 1) to give the product as a light yellow solid (114 mg, 76.4% yield).
 

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