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Chemical Structure| 479633-63-1 Chemical Structure| 479633-63-1
Chemical Structure| 479633-63-1

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Product Details of 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

CAS No. :479633-63-1
Formula : C13H10ClN3O2S
M.W : 307.76
SMILES Code : ClC1=NC=NC2=C1C=C[N]2[S](=O)(=O)C3=CC=C(C)C=C3
MDL No. :MFCD09907939
InChI Key :BTOJSYRZQZOMOK-UHFFFAOYSA-N
Pubchem ID :44228967

Safety of 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 479633-63-1 ]

[ 479633-63-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 479633-63-1 ]
  • [ 1158759-06-8 ]
  • tert-butyl 3-methyl-3-((7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
40% at 140℃; Step 5. tert-Butyl 3-methyl-3-((7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate. tert-Butyl 3-amino-3-methylpiperidine-1-carboxylate (3.3 g, 15.398 mmol) and <strong>[1158759-06-8]tert-butyl 3-amino-3-methylpiperidine-1-carboxylate</strong> (3.9 g, 12.7 mmol) was stirred at 140 C. overnight. After TLC showed <strong>[1158759-06-8]tert-butyl 3-amino-3-methylpiperidine-1-carboxylate</strong> to be consumed, the mixture was diluted with DCM (80 ml). The DCM layer was washed with sat NaHCO3 (aq) and brine and concentrated to dryness to give crude product which was purified by chromatography (silica, EtOAc/Petroleum ether, 0-40%) to give tert-butyl 3-methyl-3-((7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate (2.4 g, 40%) as a white solid
 

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