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Chemical Structure| 484-11-7 Chemical Structure| 484-11-7
Chemical Structure| 484-11-7

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Neocuproine is an organic compound commonly used as a ligand and copper ion detector. It forms stable complexes with copper ions and catalyzes specific chemical reactions and analytical methods. Neocuproine is widely applied in biomedical research, such as studies on copper metabolism disorders and neurodegenerative diseases.

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Product Details of Neocuproine

CAS No. :484-11-7
Formula : C14H12N2
M.W : 208.26
SMILES Code : CC1=CC=C(C=CC2=CC=C(C)N=C32)C3=N1
MDL No. :MFCD00004973
InChI Key :IYRGXJIJGHOCFS-UHFFFAOYSA-N
Pubchem ID :65237

Safety of Neocuproine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P280-P302+P352-P261-P304+P340-P305+P351+P338

Application In Synthesis of Neocuproine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 484-11-7 ]

[ 484-11-7 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 52522-40-4 ]
  • [ 484-11-7 ]
  • [ 17530-24-4 ]
  • [ 1132766-68-7 ]
  • 2
  • [ 52522-40-4 ]
  • [ 484-11-7 ]
  • [ 15717-50-7 ]
  • [Pd(η2-trans-1,2-bis((4-methylphenyl)sulphonyl)ethene)(2,9-dimethylphenanthroline)] [ No CAS ]
  • 3
  • [ 52522-40-4 ]
  • [ 484-11-7 ]
  • [ 762-21-0 ]
  • [ 1132766-66-5 ]
  • 4
  • [ 52522-40-4 ]
  • [ 484-11-7 ]
  • [ 106-51-4 ]
  • [Pd(η4-benzoquinone)(Neocuproine)] [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% In acetone; for 0.5h;Inert atmosphere; Darkness; General procedure: To 64.3 mg (0.278 mmol) of TTbQ-Me dissolved in anhydrous acetone (20 ml) in a two necked flask, 30 mg (0.278 mmol) of p-benzoquinone and 120 mg (0.116 mmol) of Pd2DBA3CHCl3 were added in sequence under inert atmosphere (Ar). The resulting mixture was stirred in the dark for 30 min, filtered on a celite filter and evaporated under vacuum to a small volume. Addition of Et2O induces the precipitation of the complex which was filtered off and dried in a desiccator for 5 h. 82.2 mg of the title compound as a red solid were obtained (yield 80percent).
  • 5
  • [ 484-11-7 ]
  • [ 3321-03-7 ]
  • [ 7732-18-5 ]
  • copper(II) salt [ No CAS ]
  • C25H24CuN4O3*3H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In ethanol;pH 7.0; General procedure: Heteroleptic Cu-dipeptide-necuproine complexes where L-dipeptide: Gly-Val, Gly-Leu, <strong>[3321-03-7]Gly-Phe</strong>, Ala-Gly, Ala-Phe, Val-Phe, Phe-Ala or Phe-Phe were obtained as follows (Fig. 1). 0.1mmol of dipeptide were dissolved in the minimum volume of warm water (10-50mL) and 0.1mmol of CuSO4·5H2O was added. The pH was adjusted to 7 with a 0.1M NaOH solution. A solution of 0.1mmol of neo in 5mL of ethanol was added, while stirring. The compounds were isolated by evaporation at 40-50C, until blue crystals were formed. Yield 60-70%. Crystals suitable for X-ray analysis were obtained by slow evaporation of solvent at room temperature.
 

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