[ CAS No. 762-21-0 ]

Name: 762-21-0|Diethyl acetylenedicarboxylate|98%
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SKU: A958456
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Quality Control of [ 762-21-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 762-21-0 ]

SDS Specification

Alternatived Products of [ 762-21-0 ]

Product Details of [ 762-21-0 ]

CAS No. :	762-21-0	MDL No. :	MFCD00009186
Formula :	C₈H₁₀O₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	STRNXFOUBFLVIN-UHFFFAOYSA-N
M.W :	170.16	Pubchem ID :	69803
Synonyms :

Calculated chemistry of [ 762-21-0 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.5
Num. rotatable bonds :	4
Num. H-bond acceptors :	4.0
Num. H-bond donors :	0.0
Molar Refractivity :	41.3
TPSA :	52.6 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.25 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.52
Log Po/w (XLOGP3) :	1.53
Log Po/w (WLOGP) :	0.2
Log Po/w (MLOGP) :	0.84
Log Po/w (SILICOS-IT) :	0.85
Consensus Log Po/w :	1.19

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.59
Solubility :	4.32 mg/ml ; 0.0254 mol/l
Class :	Very soluble
Log S (Ali) :	-2.24
Solubility :	0.971 mg/ml ; 0.00571 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-0.92
Solubility :	20.5 mg/ml ; 0.12 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	3.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.99

Safety of [ 762-21-0 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P501-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405	UN#:	1760
Hazard Statements:	H314	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 762-21-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 762-21-0 ]
Downstream synthetic route of [ 762-21-0 ]

[ 762-21-0 ] Synthesis Path-Upstream 1~18

1
[ 762-21-0 ]
[ 40711-33-9 ]

Reference： [1] Chemische Berichte, 1892, vol. 25, p. 3444
[2] Chemische Berichte, 1893, vol. 26, p. 1720
[3] Journal fuer Praktische Chemie (Leipzig), 1895, vol. <2>51, p. 55

2
[ 762-21-0 ]
[ 2450-71-7 ]
[ 2050-22-8 ]

Yield	Reaction Conditions	Operation in experiment
82%	With dihydrogen peroxide In ethanol at 65℃; for 12 h;	Example 1, Synthesis of diethyl pyridine-2,3-dicarboxylate:Propiolamine llg (0.2 mmol), diethyl butyldialate 34 g (0.2 mmol), 100 mL ethanol, about 26 mL & lt; RTI ID = 0.0 & gt;35percent hydrogen peroxide (0.30mmol) was added to the 250ml reaction flask, stirring, heated to 65 ° C for 12 hours, TLCThe reaction solution (petroleum ether: ethyl acetate = 2: 1 by volume) was removed and the diethyl butynoate disappeared. After recovery of ethanol by atmospheric distillation,After addition of 100 ml of water, the mixture was extracted with 50 ml of ethyl acetate, and the organic layer was combined three times (in the upper layer), followed by 50 ml of waterAnd 50 ml of saturated brine. The ethyl acetate was recovered by distillation at atmospheric pressure, followed by distillation under reduced pressure (6 mmHg), collecting 165 -170/6mmHg to obtain 36.6 g of the diethyl pyridine-2,3-dicarboxylate in a yield of 82percent.

Reference： [1] Patent: CN104447528, 2016, B, . Location in patent: Paragraph 0026; 0027

3
[ 64-17-5 ]
[ 142-45-0 ]
[ 762-21-0 ]

Yield	Reaction Conditions	Operation in experiment
91%	With toluene-4-sulfonic acid In 1,2-dichloro-ethane; toluene for 20 h; Reflux	1, ethanol (1. 2g, 26mmol), butyne acid (lg, 8. 77mmol), p-toluenesulfonic acid (30mg, 0. 17mmol) and 1,2-dichloroethane (50 mL) added to a 250mL round-bottomed flask.After refluxing for 12 hours, was added 50mL continue refluxing toluene (with trap) for 8 hours.Concentrated and purified by flash chromatography (eluent PE / EA = 98/2) give purified diethyl butyne (1.35 g of, 91percent yield).

Reference： [1] Patent: CN103483194, 2016, B, . Location in patent: Paragraph 0045
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 20, p. 4519 - 4523
[3] Journal fuer Praktische Chemie (Leipzig), 1892, vol. <2>46, p. 209[4] Journal fuer Praktische Chemie (Leipzig), 1895, vol. <2>52, p. 289,326,359,
[5] Chemische Berichte, 1885, vol. 18, p. 2271
[6] Journal of the Chemical Society, 1900, vol. 77, p. 1121
[7] Journal of the American Chemical Society, 1959, vol. 81, p. 5372
[8] Journal of the American Chemical Society, 1951, vol. 73, p. 1988
[9] Journal of the Chemical Society, 1948, p. 697

4
[ 13677-32-2 ]
[ 762-21-0 ]

Reference： [1] Synthesis, 2008, # 17, p. 2798 - 2804
[2] Helvetica Chimica Acta, 1920, vol. 3, p. 569

5
[ 13677-32-2 ]
[ 762-21-0 ]

Reference： [1] Synthesis, 2008, # 17, p. 2798 - 2804
[2] Journal fuer Praktische Chemie (Leipzig), 1892, vol. <2>46, p. 209[3] Journal fuer Praktische Chemie (Leipzig), 1895, vol. <2>52, p. 289,326,359,

6
[ 64-17-5 ]
[ 928-04-1 ]
[ 762-21-0 ]

Reference： [1] Journal of Organic Chemistry, 1980, vol. 45, # 17, p. 3523 - 3524

7
[ 29393-95-1 ]
[ 762-21-0 ]

Reference： [1] Journal of Molecular Structure, 2011, vol. 1004, # 1-3, p. 284 - 291

8
[ 29393-95-1 ]
[ 762-21-0 ]
[ 791-28-6 ]

Reference： [1] Tetrahedron Letters, 1993, vol. 34, # 35, p. 5621 - 5622
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994, # 17, p. 2467 - 2472

9
[ 137436-73-8 ]
[ 137436-80-7 ]
[ 762-21-0 ]

Reference： [1] Organometallics, [2] Organometallics, 1992, vol. 11, p. 69 - 73

10
[ 137436-75-0 ]
[ 137436-82-9 ]
[ 762-21-0 ]

Reference： [1] Organometallics, [2] Organometallics, 1992, vol. 11, p. 69 - 73

11
[ 64-17-5 ]
[ 1114-31-4 ]
[ 141-52-6 ]
[ 7070-99-7 ]
[ 762-21-0 ]

Reference： [1] Chemische Berichte, 1896, vol. 29, p. 1792
[2] Monatshefte fuer Chemie, 1893, vol. 14, p. 492

12
[ 110-86-1 ]
[ 1114-31-4 ]
[ 626-09-5 ]
[ 762-21-0 ]

Reference： [1] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1904, vol. 139, p. 870

13
[ 762-21-0 ]
[ 89-33-8 ]

Reference： [1] Journal of Organic Chemistry, 2017, vol. 82, # 5, p. 2794 - 2802

14
[ 541-98-0 ]
[ 762-21-0 ]
[ 585-81-9 ]

Reference： [1] Chemische Berichte, 1937, vol. 70, p. 1354,1359

15
[ 62-53-3 ]
[ 762-21-0 ]
[ 128942-88-1 ]

Reference： [1] Angewandte Chemie, International Edition, 2009, vol. 48, p. 4572 - 4576[2] Angewandte Chemie, 2009, vol. 121, p. 4642 - 4646

16
[ 762-21-0 ]
[ 128942-88-1 ]

Reference： [1] Synthesis, 1990, # 3, p. 215 - 218

17
[ 5570-18-3 ]
[ 762-21-0 ]
[ 128942-88-1 ]

Reference： [1] RSC Advances, 2015, vol. 5, # 47, p. 37716 - 37720

18
[ 762-21-0 ]
[ 51940-63-7 ]

Reference： [1] Patent: EP2816023, 2014, A1,
[2] Patent: WO2015/52264, 2015, A1,
[3] Patent: WO2016/11316, 2016, A1,
[4] Patent: WO2013/33085, 2013, A1,

[ 762-21-0 ] Synthesis Path-Downstream 1~68

1
[ 6640-50-2 ]
[ 762-21-0 ]
[ 66628-69-1 ]

Reference： [1]Helvetica Chimica Acta,1978,vol. 61,p. 607 - 617

2
[ 6640-50-2 ]
[ 762-21-0 ]
[ 66628-70-4 ]

Reference： [1]Helvetica Chimica Acta,1978,vol. 61,p. 607 - 617

3
[ 762-21-0 ]
[ 17220-38-1 ]
[ 67200-35-5 ]

Reference： [1]Chemistry of Heterocyclic Compounds,1978,vol. 14,p. 500 - 502
Khimiya Geterotsiklicheskikh Soedinenii,1978,vol. 14,p. 613 - 615

4
[ 693-93-6 ]
[ 762-21-0 ]
[ 30614-77-8 ]

Reference： [1]Liebigs Annalen der Chemie,1981,p. 668 - 682

5
[ 5464-79-9 ]
[ 762-21-0 ]
5-Methoxy-2-oxo-2H-9-thia-1,4a-diaza-fluorene-4-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,1993,vol. 28,p. 13 - 21

6
[ 83171-49-7 ]
[ 762-21-0 ]
[ 123157-61-9 ]
[ 123157-60-8 ]

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 1243 - 1252
[2]Journal of Medicinal Chemistry,1991,vol. 34,p. 1243 - 1252

7
[ 83171-49-7 ]
[ 762-21-0 ]
[ 123158-45-2 ]
[ 123158-44-1 ]

Yield	Reaction Conditions	Operation in experiment
		d) Treatment of <strong>[83171-49-7]3-chloro-5-iodoaniline</strong> (1.4 g) with diethylacetylene dicarboxylate (0.93 ml), as described in Example 1b, gave a mixture (1.83 g) of ethyl 5-chloro-7-iodo-4-oxo-1,4-dihydroquinoline-2-carboxylate [delta (360 MHz, DMSO-d6) 1.37 (3H, t, CH2 CH3), 4.40 (2H, q, CH2 CH3), 6.59 (1H, s, 3-H), 7.61 (1H, s, 6-H), 8.32 (1H, s, 8-H) and 11.90 (1H, bs, NH)] and ethyl 7-chloro-5-iodo-4-oxo-1,4-dihydroquinoline-2-carboxylate [delta (360 MHz, DMSO-d6) 1.37 (3H, t, CH2 CH3), 4.40 (2H, q, CH2 CH3), 6.63 (1H, s, 3-H), 7.90 (1H, s, 6-H), 8.04 (1H, s,

Reference： [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 1243 - 1252
[2]Patent: US5270309,1993,A

8
[ 75-15-0 ]
[ 2890-95-1 ]
[ 762-21-0 ]
2-((1R,2R,6S,7S)-8-Acetoxy-3,5-dithia-tricyclo[5.2.1.0^2,6]dec-4-ylidene)-[1,3]dithiole-4,5-dicarboxylic acid diethyl ester [ No CAS ]

Reference： [1]Tetrahedron Letters,1997,vol. 38,p. 7927 - 7930

9
[ 5077-67-8 ]
[ 762-21-0 ]
4-Ethyl-2,5-dihydro-furan-2,3-dicarboxylic acid diethyl ester [ No CAS ]

Reference： [1]Tetrahedron,1998,vol. 54,p. 9169 - 9174

10
[ 1820-81-1 ]
[ 762-21-0 ]
[ 234098-01-2 ]
[ 234098-04-5 ]

Reference： [1]Nucleosides and Nucleotides,1999,vol. 18,p. 673 - 674

11
[ 1820-81-1 ]
[ 762-21-0 ]
[ 234098-00-1 ]
[ 234098-04-5 ]

Reference： [1]Nucleosides and Nucleotides,1999,vol. 18,p. 673 - 674

12
[ 893-33-4 ]
[ 762-21-0 ]
diethyl 4-(2-naphthoyl)-3-trifluoromethyl-cyclobut-2-ene-1,2-dicarboxylate [ No CAS ]

Reference： [1]Synthesis,2004,p. 1029 - 1032

13
[ 762-21-0 ]
[ 5746-86-1 ]
(E)-2-(2-Pyridin-3-yl-pyrrolidin-1-yl)-but-2-enedioic acid diethyl ester [ No CAS ]

Reference： [1]Tetrahedron Letters,2005,vol. 46,p. 3953 - 3956

14
[ 94-97-3 ]
[ 603-35-0 ]
[ 762-21-0 ]
diethyl 2-(6-chlorobenzotriazol-1-yl)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]
diethyl 2-(5-chlorobenzotriazole-1-yl)-3-(triphenylphosphanylidene)butanedioate [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2006,vol. 181,p. 865 - 877

15
[ 762-21-0 ]
[ 3641-14-3 ]
1-(5-methoxycarbonyl-2<i>H</i>-[1,2,4]triazol-3-yl)-1<i>H</i>-[1,2,3]triazole-4,5-dicarboxylic acid diethyl ester [ No CAS ]

Reference： [1]Heterocycles,2005,vol. 65,p. 345 - 352

16
[ 2289-75-0 ]
[ 762-21-0 ]
2,3-dimethyl-7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; ethyl acetate; chlorobenzene;	EXAMPLE 9 A mixture of 12.8 g of <strong>[2289-75-0]2-amino-4,5-dimethylthiazole</strong>, 150 ml of ethanol and 17 g of acetylene dicarboxylic acid diethyl ester is heated to approximately 30 C., producing a weakly exothermic reaction. The mixture is left standing overnight, subsequently concentrated in vacuo to dryness and the residue is boiled for 1 hour with 100 ml of chlorobenzene. After concentration by evaporation in vacuo, the residue is treated with ethyl acetate, crystallization occurring. The product is filtered off under suction, washed with ether and dried. The 2,3-dimethyl-7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester thus obtained melts at 140 to 142 C.

Reference： [1]Patent: US4237136,1980,A

17
[ 52522-40-4 ]
[ 762-21-0 ]
Pd⁽²⁺⁾*C₄(CO₂C₂H₅)4^(2-)=[Pd(C₄(CO₂C₂H₅)4)] [ No CAS ]

Reference： [1]Organometallics,2005,vol. 24,p. 5537 - 5548

18
[ 140-29-4 ]
[ 25100-12-3 ]
[ 762-21-0 ]
3-benzyl-2-cyclohexyl-5-ethoxycarbonylmethyl-2,5-dihydro-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Synlett,2008,p. 547 - 550

19
[ 69778-83-2 ]
[ 762-21-0 ]
[ 1099824-72-2 ]

Reference： [1]Tetrahedron,2008,vol. 64,p. 11697 - 11705

20
[ 931-53-3 ]
[ 1245-13-2 ]
[ 762-21-0 ]
[ 1088610-74-5 ]

Reference： [1]Synthesis,2008,p. 2929 - 2932

21
[ 119072-55-8 ]
[ 1245-13-2 ]
[ 762-21-0 ]
[ 1088610-70-1 ]

Reference： [1]Synthesis,2008,p. 2929 - 2932

22
[ 52522-40-4 ]
[ 484-11-7 ]
[ 762-21-0 ]
[ 1132766-66-5 ]

Reference： [1]Journal of Organometallic Chemistry,2009,vol. 694,p. 411 - 419

23
[ 893-33-4 ]
[ 603-35-0 ]
[ 762-21-0 ]
C₄₀H₃₄F₃O₆P [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2008,vol. 183,p. 1564 - 1570

24
[ 60481-38-1 ]
[ 762-21-0 ]
[ 1138036-75-5 ]

Yield	Reaction Conditions	Operation in experiment
43%	With potassium carbonate; In ethanol; for 18h;Heating / reflux;	Reference Example 200 Ethyl 1-(2,3-difluorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylate To a solution of <strong>[60481-38-1](2,3-difluorophenyl)hydrazine hydrochloride</strong> (32.6 g) in ethanol (452 mL) were added potassium carbonate (62.5 g) and diethyl but-2-ynedioate (38.5 g), and the mixture was refluxed for 18 hr, and concentrated under reduced pressure. The residue was treated with 2 mol/L hydrochloric acid, and the mixture was extracted twice with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was suspended in diethyl ether, and the obtained solid was collected by filtration, and dried under reduced pressure to give the title compound as a pale-yellow solid (26.0 g, yield 43%). 1H-NMR (DMSO-d6) delta: 1.29 (3H, t, J=7.2 Hz), 4.28 (2H, q, J=7.2 Hz), 5.96 (1H, s), 7.36-7.45 (2H, m), 7.59-7.66 (1H, m), 12.2 (1H, s).

Reference： [1]Patent: US2009/156642,2009,A1 .Location in patent: Page/Page column 69

25
[ 461-89-2 ]
[ 762-21-0 ]
diethyl 2-(6-azauracil-3-yl)-3-(triphenylphosphoranylidene)-butanedioate [ No CAS ]
diethyl 2-(6-azauracil-3-yl)-3-(triphenylphosphoranylidene)-butanedioate [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2009,vol. 184,p. 2959 - 2979

26
[ 21443-96-9 ]
[ 762-21-0 ]
[ 1234863-03-6 ]

Reference： [1]Synthetic Communications,2010,vol. 40,p. 2130 - 2137

27
[ 57476-50-3 ]
[ 931-53-3 ]
[ 762-21-0 ]
[ 1253586-91-2 ]

Reference： [1]Synthesis,2010,p. 2571 - 2576

28
[ 57476-50-3 ]
[ 119072-55-8 ]
[ 762-21-0 ]
[ 1253586-92-3 ]

Reference： [1]Synthesis,2010,p. 2571 - 2576

29
[ 57476-50-3 ]
[ 14542-93-9 ]
[ 762-21-0 ]
[ 1253586-93-4 ]

Reference： [1]Synthesis,2010,p. 2571 - 2576

30
[ 461-89-2 ]
[ 603-35-0 ]
[ 762-21-0 ]
[ 1228566-68-4 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2011,vol. 186,p. 21 - 30

31
[ 931-53-3 ]
[ 556-90-1 ]
[ 762-21-0 ]
[ 1361299-51-5 ]

Yield	Reaction Conditions	Operation in experiment
70%	In dichloromethane; at 20℃; for 24.1667h;	General procedure: To a stirred solution of dimethyl acetylenedicarboxylate (0.14 g, 1 mmol) and <strong>[556-90-1]2-imino-1,3-thiazolidin-4-one</strong> (3) (0.118 g, 1 mmol) in anhydrous CH2Cl2 (5 mL) was added dropwise a solution of cyclohexyl isocyanide (0.083 g, 1 mmol) in anhydrous CH2Cl2 (3 mL) at rt over 10 min. The reaction mixture was then stirred for 24 h. The solvent was removed under reduced pressure and the residue purified by silica gel (Merck 230-240 mesh) column chromatography using hexane-EtOAc as eluent to yield 4a.

Reference： [1]Tetrahedron Letters,2012,vol. 53,p. 1351 - 1353

32
[ 119072-55-8 ]
[ 556-90-1 ]
[ 762-21-0 ]
[ 1361299-54-8 ]

Yield	Reaction Conditions	Operation in experiment
78%	In dichloromethane; at 20℃; for 24.1667h;	General procedure: To a stirred solution of dimethyl acetylenedicarboxylate (0.14 g, 1 mmol) and <strong>[556-90-1]2-imino-1,3-thiazolidin-4-one</strong> (3) (0.118 g, 1 mmol) in anhydrous CH2Cl2 (5 mL) was added dropwise a solution of cyclohexyl isocyanide (0.083 g, 1 mmol) in anhydrous CH2Cl2 (3 mL) at rt over 10 min. The reaction mixture was then stirred for 24 h. The solvent was removed under reduced pressure and the residue purified by silica gel (Merck 230-240 mesh) column chromatography using hexane-EtOAc as eluent to yield 4a.

Reference： [1]Tetrahedron Letters,2012,vol. 53,p. 1351 - 1353

33
[ 14542-93-9 ]
[ 556-90-1 ]
[ 762-21-0 ]
[ 1361299-57-1 ]

Yield	Reaction Conditions	Operation in experiment
75%	In dichloromethane; at 20℃; for 24.1667h;	General procedure: To a stirred solution of dimethyl acetylenedicarboxylate (0.14 g, 1 mmol) and <strong>[556-90-1]2-imino-1,3-thiazolidin-4-one</strong> (3) (0.118 g, 1 mmol) in anhydrous CH2Cl2 (5 mL) was added dropwise a solution of cyclohexyl isocyanide (0.083 g, 1 mmol) in anhydrous CH2Cl2 (3 mL) at rt over 10 min. The reaction mixture was then stirred for 24 h. The solvent was removed under reduced pressure and the residue purified by silica gel (Merck 230-240 mesh) column chromatography using hexane-EtOAc as eluent to yield 4a.

Reference： [1]Tetrahedron Letters,2012,vol. 53,p. 1351 - 1353

34
[ 119072-55-8 ]
[ 762-21-0 ]
[ 56059-30-4 ]
[ 1381804-67-6 ]

Reference： [1]Chinese Chemical Letters,2012,vol. 23,p. 677 - 680

35
[ 816-39-7 ]
[ 119072-55-8 ]
[ 762-21-0 ]
[ 1379588-57-4 ]

Reference： [1]Synthetic Communications,2012,vol. 42,p. 2894 - 2906

36
[ 85920-63-4 ]
[ 603-35-0 ]
[ 762-21-0 ]
[ 1384486-04-7 ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2012,vol. 187,p. 1109 - 1117

37
[ 2058-72-2 ]
[ 762-21-0 ]
[ 109-77-3 ]
[ 1383918-92-0 ]

Yield	Reaction Conditions	Operation in experiment
90%	With 4-amino-o-xylene; In ethanol; at 20℃; for 8h;	General procedure: A mixture of isatin 1 (1 mmol) and malononitrile (2) (1 mmol) in EtOH (3 mL) was stirred for 15 min then treated with a solution of dialkyl acetylenedicarboxylate 3 (1 mmol) and 3,4-dimethylaniline (1 mmol) in EtOH (1 mL). The mixture was stirred at room temperature for 8 h. After completion of the reaction (TLC, eluent: EtOAc/hexane, 1:2), the mixture was filtered and the precipitate washed with H2O (5 mL) and EtOH (5 mL) to afford the pure product 4.

Reference： [1]Tetrahedron Letters,2012,vol. 53,p. 3603 - 3606

38
[ 603-35-0 ]
[ 132712-71-1 ]
[ 762-21-0 ]
C₃₀H₃₁N₂O₅P [ No CAS ]
C₃₀H₃₁N₂O₅P [ No CAS ]

Reference： [1]Chinese Journal of Chemistry,2012,vol. 30,p. 1893 - 1900

39
[ 762-21-0 ]
[ 51940-63-7 ]

Reference： [1]Patent: EP2816023,2014,A1
[2]Patent: WO2015/52264,2015,A1
[3]Patent: WO2016/11316,2016,A1
[4]Patent: WO2013/33085,2013,A1

40
[ 2058-72-2 ]
[ 6829-40-9 ]
[ 762-21-0 ]
[ 1459805-78-7 ]

Reference： [1]RSC Advances,2013,vol. 3,p. 10875 - 10886

41
[ 6829-40-9 ]
[ 391-12-8 ]
[ 762-21-0 ]
[ 1459805-81-2 ]

Reference： [1]RSC Advances,2013,vol. 3,p. 10875 - 10886

42
[ 50910-55-9 ]
[ 762-21-0 ]
diethyl 6,8-dibromoquinoline-2,3-dicarboxylate [ No CAS ]

Reference： [1]RSC Advances,2013,vol. 3,p. 22039 - 22045

43
[ 1140-17-6 ]
[ 762-21-0 ]
diethyl 4-(4-bromophenyl)quinoline-2,3-dicarboxylate [ No CAS ]

Reference： [1]RSC Advances,2013,vol. 3,p. 22039 - 22045

44
[ 119-65-3 ]
[ 28868-76-0 ]
[ 762-21-0 ]
(4aS,13bS,13cS,17bS)-2,3,5,6-tetraethyl-1,1-dimethyl-1H-benzo[c]isoquinolino[1,2-f]pyrrolo[1,2-a][1,6]naphthyridine-1,1,2,3,5,6(4aH,13bH,13cH,17bH)hexacarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	In dichloromethane; at -10 - 20℃; for 12h;	General procedure: To a stirred solution of 2 (2 mmol) and 3 (2 mmol) in 10 mL of CH2Cl2was added 0.24 mL of isoquinoline (2 mmol) dropwise at 10 8Cover 5 min. The reaction mixture was then allowed to warm toroom temperature and stand for 12 h. The solvent was removedunder reduced pressure, and the residue was purified by silica gel(Merck 230-240 mesh) column chromatography using n-hexane/EtOAc (3:1) mixture as eluent to afford the pure product.

Reference： [1]Chinese Chemical Letters,2013,vol. 24,p. 979 - 983

45
[ 13362-30-6 ]
[ 762-21-0 ]
[ 1589518-41-1 ]

Yield	Reaction Conditions	Operation in experiment
56%	In water; at 20℃; for 6h;	General procedure: A flaskwas charged with 1 (0.32 mmol) andwater (30 mL). Then2 (0.38 mmol) was added to the reaction system. The reaction wasstirred at room temperature for 6 h in air. Then the reaction wasextracted with CH2Cl2 (20 mL) and dried over anhydrous Na2SO4.After the solvent was evaporated in vacuo, the residues were purifiedby column chromatography, eluting with petroleum ether(PE)eEtOAc to afford pure 3.

Reference： [1]Tetrahedron,2014,vol. 70,p. 2761 - 2765

46
[ 1016-78-0 ]
[ 762-21-0 ]
[ 1220115-62-7 ]

Reference： [1]RSC Advances,2014,vol. 4,p. 15154 - 15160

47
[ 575-03-1 ]
[ 762-21-0 ]
ethyl 2,8-dioxo-4-(trifluoromethyl)-2H,8H-pyrano[2,3-f]chromene-10-carboxylate [ No CAS ]

Reference： [1]Letters in Organic Chemistry,2015,vol. 12,p. 50 - 54

48
[ 91-22-5 ]
[ 28868-76-0 ]
[ 762-21-0 ]
1,2-diethyl 3,3-dimethyl pyrrolo[1,2-a]quinolone-1,2,3,3(3aH)-tetracarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	In methanol; at 20℃; for 12h;	General procedure: To a stirred solution of dialkylacetylenedicarboxylates(1 mmol) and 3 (1 mmol) in MeOH (5 ml) was added dropwisea mixture of quinoline (1 mmol) in MeOH (3 ml).The mixture was stirred for 12 h. The solvent was removed under reduced pressure, and the residue was purified by column chromatography (SiO2; hexane/AcOEt 5:1) toafford the pure title compounds.

Reference： [1]Journal of the Iranian Chemical Society,2016,vol. 13,p. 743 - 746

49
[ 6665-86-7 ]
[ 762-21-0 ]
ethyl 4,8-dioxo-2-phenyl-4,8-dihydropyrano[2,3-f]chromene-10-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
66%	With triphenylphosphine; In N,N-dimethyl-formamide; at 60℃; for 12h;	A mixture of 7-hydroxy flavones 3a-3c (1mmol) and PPh3 (1.5 mmol) in DMF(8 mL) was stirred at room temperature for 10 min.Dialkylacetalynedicarboxylate (1.5 mmol) in DMF was added drop wise in 10 min. The brown solutionthus obtained was heated at 60C for 12 h. Then the reaction mixture was diluted with ice cold water and extracted with CH2Cl2. The organic layer was washedwith brine and dried over Na2SO4. The solvent was evaporated under reduced pressure to give a crude mass. The product was isolated by silica gel (100-200 mesh) column chromatography using EtOAc-Petrolium ether (2 : 8) as an eluent, giving pure solidproducts 4a-4f (65-82%).

Reference： [1]Russian Journal of General Chemistry,2016,vol. 86,p. 1126 - 1131
Zh. Obshch. Khim.,2016,vol. 86,p. 1126 - 1131,6

50
[ 53590-49-1 ]
[ 762-21-0 ]
diethyl 7-chloro-9H-pyrrolo[1,2-a]indole-2,3-dicarboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2016,vol. 81,p. 4371 - 4377

51
[ 931-33-9 ]
[ 762-21-0 ]
diethyl 2-bromo-3H-pyrrolizine-5,6-dicarboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2016,vol. 81,p. 4371 - 4377

52
[ 500-22-1 ]
[ 28868-76-0 ]
[ 762-21-0 ]
1-methyl 2,3-diethyl 6-formylindolizine-1,2,3-tricarboxylate [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2017,vol. 54,p. 743 - 748

53
[ 456-14-4 ]
[ 762-21-0 ]
tetraethyl 8-fluoroimidazo[2,1-a]isoquinoline-2,3,5,6-tetracarboxylate [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2017,vol. 15,p. 3491 - 3498

54
[ 931-53-3 ]
[ 550-24-3 ]
[ 762-21-0 ]
diethyl 2-(cyclohexylamino)-5,8-dihydro-6-hydroxy-5,8-dioxo-7-undecyl-4H-chromene-3,4-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	In acetonitrile; at 20℃; for 24h;	General procedure: A mixture of <strong>[550-24-3]2,5-dihydroxy-6-undecyl-1,4-benzoquinone</strong> (1 mmol), diethylacetylene dicarboxylate (1 mmol) and isocyanides (1 mmol) was stirred in CH3CN (5 mL) at RT for 24 h. The progress of the reaction was monitored by TLC (20% methanol in chloroform). After completion of the reaction, the separated solid was filtered off and washed with hexane. The crude product was purified by recrystallization from ethanol to give 4.

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2016,vol. 55B,p. 1420 - 1423

55
[ 119072-55-8 ]
[ 550-24-3 ]
[ 762-21-0 ]
diethyl 2-(tert-butylamino)-5,8-dihydro-6-hydroxy-5,8-dioxo-7-undecyl-4H-chromene-3,4-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	In acetonitrile; at 20℃; for 24h;	General procedure: A mixture of <strong>[550-24-3]2,5-dihydroxy-6-undecyl-1,4-benzoquinone</strong> (1 mmol), diethylacetylene dicarboxylate (1 mmol) and isocyanides (1 mmol) was stirred in CH3CN (5 mL) at RT for 24 h. The progress of the reaction was monitored by TLC (20% methanol in chloroform). After completion of the reaction, the separated solid was filtered off and washed with hexane. The crude product was purified by recrystallization from ethanol to give 4.

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2016,vol. 55B,p. 1420 - 1423

56
[ 550-24-3 ]
[ 119072-54-7 ]
[ 762-21-0 ]
diethyl 2-(2,6-dimethylphenylamino)-5,8-dihydro-6-hydroxy-5,8-dioxo-7-undecyl-4H-chromene-3,4-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	In acetonitrile; at 20℃; for 24h;	General procedure: A mixture of <strong>[550-24-3]2,5-dihydroxy-6-undecyl-1,4-benzoquinone</strong> (1 mmol), diethylacetylene dicarboxylate (1 mmol) and isocyanides (1 mmol) was stirred in CH3CN (5 mL) at RT for 24 h. The progress of the reaction was monitored by TLC (20% methanol in chloroform). After completion of the reaction, the separated solid was filtered off and washed with hexane. The crude product was purified by recrystallization from ethanol to give 4.

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2016,vol. 55B,p. 1420 - 1423

57
[ 91-63-4 ]
[ 22927-13-5 ]
[ 762-21-0 ]
diethyl 3-(2-ethylbenzyl)pyrrolo[1,2-a]quinoline-1,2-dicarboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2017,vol. 82,p. 4289 - 4296

58
[ 1145-81-9 ]
[ 762-21-0 ]
1-benzyl 2,3-diethyl 4-ethoxy-1H-pyrrole-1,2,3(2H,5H)-tricarboxylate [ No CAS ]

Reference： [1]Advanced Synthesis and Catalysis,2017,vol. 359,p. 2304 - 2315

59
[ 1145-81-9 ]
[ 762-21-0 ]
1-benzyl 2,3-diethyl 4-ethoxy-1H-pyrrole-1,2,3(2H,5H)-tricarboxylate [ No CAS ]
1-benzyl 2,3-diethyl 4-ethoxy-1H-pyrrole-1,2,3(2H,5H)-tricarboxylate [ No CAS ]

Reference： [1]Advanced Synthesis and Catalysis,2017,vol. 359,p. 2304 - 2315

60
[ 1145-81-9 ]
[ 603-35-0 ]
[ 762-21-0 ]
1-benzyl 2,3-diethyl 4-ethoxy-1H-pyrrole-1,2,3(2H,5H)-tricarboxylate [ No CAS ]
[ 791-28-6 ]

Reference： [1]Advanced Synthesis and Catalysis,2017,vol. 359,p. 2304 - 2315

61
[ 1145-81-9 ]
[ 603-35-0 ]
[ 762-21-0 ]
C₃₈H₄₀NO₈P [ No CAS ]

Reference： [1]Advanced Synthesis and Catalysis,2017,vol. 359,p. 2304 - 2315

62
[ 230299-21-5 ]
[ 762-21-0 ]
(E)-diethyl 2,3-bis(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)fumarate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%	With 4,4'-bipyridine; In tetrahydrofuran; at 60℃; for 14h;Inert atmosphere; Sealed tube;	In a glove box, a glass tube having PTFE stopcock (J. Young),equipped with a magnetic stirring bar, was charged with 9e (1.7 mg, 0.010 mmol), 11 (58 mg,0.23 mmol), THF (0.2 mL), and 7a (34 mg, 0.20 mmol). The tube was sealed by the stopcock and was taken out from the glove box. The mixture was heated at 60 °C with stirring for 14 h.After cooling to room temperature, the volatiles were removed from the reaction mixture under reduced pressure. The residue was purified by column chromatography on silica gel(CHROMATOREX DIOL, eluent: hexane:CHCl3 = 5:1) to afford (E)-12b (54 mg, 63percent) as awhite solid. Geometry of the carbon?carbon double bond was assigned on the analogy of that of (E)-8a. Diethyl 2,3-bis(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)fumarate [(E)-12b]1H NMR (400 MHz, CDCl3) delta 4.11-4.32 (m, 6H), 1.62-1.79 (m, 4H), 1.34 (s, 6H), 1.27 (t, J =6.8 Hz, 6H), 1.26 (s, 6H), 1.22 (d, J = 6.4 Hz, 6H). 13C NMR (101 MHz, CDCl3) delta 168.9, 150.3(broad, C?B), 71.2, 65.3, 61.0, 45.8, 31.2, 27.54 (either meso or racemate), 27.52 (either mesoor racemate), 23.1, 14.2. 11B NMR (128 MHz, CDCl3) delta 26.1. HRMS (ESI, positive) m/z calcdfor C20H34B2O8Na+ [M + Na]+: 447.2332, found: 447.2332.

Reference： [1]Chemistry Letters,2017,vol. 46,p. 1793 - 1796

63
[ 39989-43-0 ]
[ 103-72-0 ]
[ 762-21-0 ]
ethyl (Z)-2-((Z)-3-(3,5-dichlorobenzyl)-4-oxo-2-(phenylimino)thiazolidin-5-ylidene)acetate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2019,vol. 84,p. 6448 - 6458

64
[ 119072-55-8 ]
[ 301359-45-5 ]
[ 762-21-0 ]
triethyl 5-(2-chlorophenyl)-7-methyl-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-2,3,6-tricarboxylate [ No CAS ]

Reference： [1]Chemistry and biodiversity,2019,vol. 16

65
[ 885518-25-2 ]
[ 104-87-0 ]
[ 762-21-0 ]
diethyl 8-fluoro-3-(p-tolyl)-1H-azepino[4,3,2-cd]indole-4,5-dicarboxylate [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2019,vol. 17,p. 5982 - 5989

66
[ 582-65-0 ]
[ 762-21-0 ]
diethyl 4-(4-fluorobenzoyl)-3-(trifluoromethyl)cyclobut-2-ene-1,2-dicarboxylate [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 10142 - 10147

67
[ 720-94-5 ]
[ 762-21-0 ]
diethyl 4-(4-methylbenzoyl)-3-(trifluoromethyl)cyclobut-2-ene-1,2-dicarboxylate [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2019,vol. 141,p. 10142 - 10147

68
[ 885518-25-2 ]
[ 100-52-7 ]
[ 762-21-0 ]
diethyl 5-fluoro-4-phenyl-4,7-dihydro-1H-pyrrolo[2,3-h]quinoline-2,3-dicarboxylate [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2020,vol. 18,p. 215 - 219

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
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Prevention
Code	Phrase
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P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
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P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
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P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
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P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
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P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
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P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
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P332	IF SKIN irritation occurs:
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P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
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P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
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P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
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Storage
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P401
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Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 762-21-0 ]

Quality Control of [ 762-21-0 ]

Related Doc. of [ 762-21-0 ]

Product Details of [ 762-21-0 ]

Calculated chemistry of [ 762-21-0 ]

Physicochemical Properties

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Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 762-21-0 ]

Application In Synthesis of [ 762-21-0 ]

[ 762-21-0 ] Synthesis Path-Upstream 1~18

[ 762-21-0 ] Synthesis Path-Downstream 1~68

Related Functional Groups of [ 762-21-0 ]

Alkynyls

Aliphatic Chain Hydrocarbons

Esters

Precautionary Statements-General

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Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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[ 762-21-0 ]