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Chemical Structure| 493036-47-8 Chemical Structure| 493036-47-8

Structure of 493036-47-8

Chemical Structure| 493036-47-8

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Product Details of [ 493036-47-8 ]

CAS No. :493036-47-8
Formula : C9H7FO2
M.W : 166.15
SMILES Code : O=CC(C1=CC=C(F)C=C1)C=O
MDL No. :MFCD02261897

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Application In Synthesis of [ 493036-47-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 493036-47-8 ]

[ 493036-47-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 493036-47-8 ]
  • [ 108290-86-4 ]
  • ethyl 3-(4-fluorophenyl)pyrrolo[1,2-a]pyrimidine-8-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
26% With acetic acid; at 90℃; for 2h; To a solution of ethyl 2-amino- 1H-pyrrole-3-carboxylate (500 mg, 3.24 mmol) inAcOH (15 mL) was added 2-(4-fluorophenyl)malonaldehyde (664 mg, 4.0 mmol) at 90 C. Then the reaction mixture was stirred for 2 h at 90 C, cooled, and concentrated in vacuo. The residue was purified by silica gel column (PE/EA = 3/1) to afford ethyl 3-(4- fluorophenyl)pyrrolo[ 1 ,2-ajpyrimidine-8-carboxylate (252 mg, 26%) as a yellow solid. LC-MSmlz: 239.0 [M+Hf?.
 

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