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Chemical Structure| 49667-81-4 Chemical Structure| 49667-81-4

Structure of 49667-81-4

Chemical Structure| 49667-81-4

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Product Details of [ 49667-81-4 ]

CAS No. :49667-81-4
Formula : C9H12N2O2
M.W : 180.20
SMILES Code : O=C(NCCO)C1=CC=CC=C1N
MDL No. :MFCD00456226

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Application In Synthesis of [ 49667-81-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 49667-81-4 ]

[ 49667-81-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 49667-81-4 ]
  • [ 150374-99-5 ]
  • 4-(N-(2-(2-hydroxyethylcarbamoyl)phenyl)sulfamoyl)phenyl pivalate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; In dichloromethane; at 20℃; for 4h; To a solution of isoatic anhydride (1 mmol) in terahydrofuran(THF, 5 mL) were added ethylanolamine (1.5 mmol), and the mixturewas stirred at room temperature for 12 h. The resulting solutionwas concentrated in vacuum to yield a crude residue whichwas purified by chromatography on silica gel (acetone/hexane= 1:1) to provide intermediate 2-amino-N-(2-hydroxyethyl)benzamide. The intermediate (0.2 mmol) was dissolved in10% pyridine/DCM solution (5 mL), and 4-(chlorosulfonyl)phenylpivalate, which obtaining as Scheme 1 described, was added slowlyat room temperature, then; the mixture was stirred at same temperaturefor 4 h. The resulting solution was concentrated and purifiedby chromatography on silica gel (acetone/hexane = 1:1) tofurnish 22 (yielding 72%, Scheme 8),
 

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