5-Bromo-2,3-dihydro-1H-inden-1-one | Aryls

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CAS No. :	34598-49-7
Formula :	C₉H₇BrO
M.W :	211.06
SMILES Code :	O=C1CCC2=C1C=CC(Br)=C2
MDL No. :	MFCD00082718
InChI Key :	KSONICAHAPRCMV-UHFFFAOYSA-N
Pubchem ID :	520695

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302+H312+H332-H315-H319-H335
Precautionary Statements:	P261-P280-P305+P351+P338

Yield	Reaction Conditions	Operation in experiment
67%	With hydrogenchloride; sodium chloride;aluminium chloride;	A mixture of aluminium chloride (54 g) and sodium chloride (11.8 g) was stirred and heated to 200 C. 4-Bromophenyl 2-chloroethyl ketone (10 g) and added portionwise and the mixture was maintained at 200 C. for 2 hours. The mixture was poured onto a mixture of ice and 1N aqueous hydrochloric acid. The resultant mixture was extracted with ethyl acetate. The organic solution was washed with a saturated aqueous sodium bicarbonate solution and with water, dried (MgSO4) and evaporated. The residue was purified by column chromatography using increasingly polar mixtures of petroleum ether and ethyl acetate as eluent. There was thus obtained 5-bromoindan-1-one (5.7 g, 67%).
	With sulfuric acid; at 100℃; for 2h;Inert atmosphere;	To a 100 ml round bottom flask equipped with a condenser, 3-chloro-1 -(4-bromo)propanone (1 .55 g, 6.35 mmol) and H2S04 98% (35 ml, 644 mmol) were added. This brown mixture was heated to 100 C for 2 h under argon flown. The dark brown solution obtained was cooled down to room temperature and added onto ice. The organic product was extracted with diethylether (3 x 30 ml) and the organic phase was washed with aqueous NaHCC>3 and brine and dried over Na2S04. After evaporation of the solvents, 5-bromo-1 -indanone was obtained as a brown solid.1H NMR for 5-bromo-1-indanone (300 MHz, Chloroform-d) o 7.65 (t, J = 0.9, 0.5 Hz, 1 H, 4a),7.59 (d, J = 8.2 Hz, 1 H, 6a), 7.50 (dt, J = 8.2, 0.9 Hz, 1 H, 7a), 3.13 (t, J = 6.1, 5.7 Hz, 2H, 2a, 2b), 2.69 (t, J = 6.0 Hz, 2H, 3a, 3b).

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CAS No.: 34598-49-7

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CAS No.: 34598-49-7

Alternative Products

Product Details of 5-Bromo-2,3-dihydro-1H-inden-1-one

Safety of 5-Bromo-2,3-dihydro-1H-inden-1-one

Application In Synthesis of 5-Bromo-2,3-dihydro-1H-inden-1-one

[ 34598-49-7 ] Synthesis Path-Upstream 1~1

[ 34598-49-7 ] Synthesis Path-Downstream 1~7

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
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