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Chemical Structure| 50259-93-3 Chemical Structure| 50259-93-3

Structure of 50259-93-3

Chemical Structure| 50259-93-3

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Product Details of [ 50259-93-3 ]

CAS No. :50259-93-3
Formula : C14H8Cl2O
M.W : 263.12
SMILES Code : O=C1C2=C(C=CC=C2Cl)CC3=CC=CC(Cl)=C13
MDL No. :MFCD00229548

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Application In Synthesis of [ 50259-93-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 50259-93-3 ]

[ 50259-93-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 50259-93-3 ]
  • [ 13380-67-1 ]
  • C24H14BrCl2NO3 [ No CAS ]
  • C24H14BrCl2NO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: All reactions were run in closed 50 mL polyethylene vessels. To a solution of anthrone (0.15-0.60 mmol) in CH2Cl2or other solvents (abs., 8 mL) at -40 C, the catalyst 10 (0.1 equiv) was added. After stirring for 15 minutes, maleimide was added to the mixture in one portion. The solution was allowed to warm up to -15 C overnight and stirred for two more days at this temperature. After warming up to room temperature the reaction mixture was purified by flash column chromatography (c-hexane/EtOAc 10:1) to afford the different products as crystalline solids.
  • 2
  • [ 50259-93-3 ]
  • [ 13380-67-1 ]
  • C24H14BrCl2NO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With lithium perchlorate; triethylamine; In chloroform; at 20℃; for 168h; General procedure: All reactions were run in closed 50 mL polyethylene vessels. To a solution of anthrone (0.15-0.60 mmol) in CH2Cl2or other solvents (abs., 8 mL) at -40 C, the catalyst 10 (0.1 equiv) was added. After stirring for 15 minutes, maleimide was added to the mixture in one portion. The solution was allowed to warm up to -15 C overnight and stirred for two more days at this temperature. After warming up to room temperature the reaction mixture was purified by flash column chromatography (c-hexane/EtOAc 10:1) to afford the different products as crystalline solids. The racemic Diels-Alder products rac-25-rac-27 were prepared with triethylamine (1.0 equiv) instead of guanidine 10. After stirring for 24 hours at room temperature the reaction mixture was also purified by flash column chromatography (c-hexane/EtOAc 10:1).The racemic retro-aldol products rac-28-rac-31 were prepared with triethylamine (1.0 equiv.) instead of guanidine in the presence of a small amount of LiClO4acting as Lewis acid. After stirring for 7 days at room temperature the reaction mixture was also purified by flash column chromatography (c-hexane/EtOAc 10:1).
 

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