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Chemical Structure| 50424-88-9 Chemical Structure| 50424-88-9

Structure of 50424-88-9

Chemical Structure| 50424-88-9

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Product Details of [ 50424-88-9 ]

CAS No. :50424-88-9
Formula : C7H3ClFNO3
M.W : 203.56
SMILES Code : O=C(Cl)C1=C([N+]([O-])=O)C=CC=C1F
MDL No. :MFCD13185618

Safety of [ 50424-88-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P260-P264-P270-P280-P301+P312-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P330-P363-P405-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 50424-88-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 50424-88-9 ]

[ 50424-88-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 159783-22-9 ]
  • [ 50424-88-9 ]
  • [ 1365992-92-2 ]
  • [ 1365992-93-3 ]
YieldReaction ConditionsOperation in experiment
A solution of 2-fluoro-6-nitrobenzoyl chloride (10.97 g, 52.4 mmol) in dioxane (20 mL) was added dropwise over 5 minutes to a solution of 3,5- difluoropyridin-4-ylamine (6.19 g, 47.6 mmol) in pyridine (80 mL) at room temperature under argon. The reaction mixture was stirred at room temperature for 18 hours then the volatiles were removed under reduced pressure. To the resultant residue, HCl (IN, 100 mL) was added and the suspension was sonicated and then stirred at room temperature for 30 minutes. The resultant solid was filtered and dried to afford a mixture of 2- fluoro-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide {LCMS (Method D): RT = 2.67 min, m/z: 298 [M+H+] and 2-chloro-N-(2-fluoro-6-nitrobenzoyl)-N-(3,5-difluoropyridin-4-yl)-6-nitrobenzamide {LCMS (Method D): RT = 3.63 min, m/z: 465[M+H+]. NaOH (IN, 100 mL) was added to a suspension of this solid in MeOH (100 mL) at room temperature under argon. The reaction mixture was heated at 60 C for 1.5 hours, allowed to cool to room temperature, and then the organic solvent was removed in vacuo. The resultant mixture was made acidic (pH 2-3) by addition of 12N HCl and was then cooled to 0 C. The resultant solid was filtered and dried to afford the title compound as a pale yellow solid (10.81 g, 76% yield). LCMS (Method D): RT = 2.66 min, m/z: 298 [M+H+].
 

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