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Chemical Structure| 504438-04-4 Chemical Structure| 504438-04-4

Structure of 504438-04-4

Chemical Structure| 504438-04-4

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Product Details of [ 504438-04-4 ]

CAS No. :504438-04-4
Formula : C11H17NO3
M.W : 211.26
SMILES Code : O=C(O)N(C(C)(C)C)[C@@H]([C@]1([H])C2)[C@@]1([H])CC2=O

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Application In Synthesis of [ 504438-04-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 504438-04-4 ]

[ 504438-04-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 504438-04-4 ]
  • [ 1000342-95-9 ]
  • tert-butyl ((1R,3r,5S,6r)-3-hydroxy-3-(6-(trifluoromethyl)-1H-indazol-4-yl)bicyclo[3.1.0]hexan-6-yl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
21% To a solution of 4-bromo-6- (trifluoromethyl) -1H-indazole (3 g, 11.32 mmol) in THF (60 mL) cooled to -78 °C in a liquid nitrogen/acetone bath was added dropwise n-BuLi/THF (2.5M, 15 mL, 37.36 mmol), maintaining the inner temperature below -75 °C. After being stirred at -78 °C for 0.5 h, a solution of tert-butyl ((1R,5S,6r)-3-oxobicyclo[3.1.0]hexan-6-yl)carbamate (2.42 g, 11.32 mmol) in THF (10 mL) was added dropwise to the reaction mixture, maintaining the inner temperature below -75 °C. After the addition, the reaction was stirred at -78 °C for 1 h before quenching with NH 4Cl (sat. aq, 80 mL) and diluted with EtOAc (150 mL). The organic layer was separated, which was washed with H 2O (80 mL 2) and brine (80 mL), dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by silica gel flash column chromatography (PE: EtOAc = 10: 13: 2) to give the title compound (950 mg, yield: 21percent).
 

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• Acyl Group Substitution • Arndt-Eistert Homologation • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Grignard Reaction • Halogenation • Heat of Combustion • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Preparation of Carboxylic Acids • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Carboxylic Acids • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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