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Chemical Structure| 50622-09-8 Chemical Structure| 50622-09-8

Structure of 50622-09-8

Chemical Structure| 50622-09-8

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Product Details of [ 50622-09-8 ]

CAS No. :50622-09-8
Formula : C7H14O4
M.W : 162.18
SMILES Code : CC1(C)O[C@@H](CO)[C@H](CO)O1
MDL No. :MFCD00063761
InChI Key :INVRLGIKFANLFP-WDSKDSINSA-N
Pubchem ID :785242

Safety of [ 50622-09-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 50622-09-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 50622-09-8 ]

[ 50622-09-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 50622-09-8 ]
  • [ 149-32-6 ]
  • 2
  • [ 50622-09-8 ]
  • [ 65838-10-0 ]
  • C47H60N4O4P2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
41% General procedure: (R,R)-N,N?-dibenzyl-1,2-cyclohexanediamine (1.06 g, 3.6 mmol) and NEt3 (1.50 mL, 10.8 mmol) were dissolved in 10 mL of toluene.PCl3 (0.40 mL, 4.6 mmol) dissolved in 5 mL of toluene was addeddrop wise at 0 C. The mixture was allowed to warm up to roomtemperature and was stirred for 2 h. The formation of the chlorodiazaphospholidinewas monitored by 31P NMR spectroscopy(d 174.5 ppm) being complete after this period. The solvent andthe excess of PCl3 were thoroughly removed under reduced pressureto afford a viscous oil. This oil was dissolved in toluene (10 mL)and 1.3 mL of NEt3 was added. The corresponding diol (1.8 mmol),((S,S)-2,3-butanediol in toluene (10 mL), (4S,5S)-4,5-di(hydroxymethyl)-2,2-dimethyl-1,3-dioxolane and (R)-1,1?-bi-2-naphthol in THF (10 mL)) was added dropwise at 0 C. After 4 hof stirring, the white precipitate of triethylamine hydrochloridewas filtered off. The solvent was removed in vacuum and ayellowish oil was obtained and used without purification.
 

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