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Chemical Structure| 508203-26-7 Chemical Structure| 508203-26-7

Structure of 508203-26-7

Chemical Structure| 508203-26-7

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Product Details of [ 508203-26-7 ]

CAS No. :508203-26-7
Formula : C7H4ClF2NO
M.W : 191.56
SMILES Code : O=C(N)C1=CC(F)=C(Cl)C=C1F
MDL No. :MFCD11847045

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Application In Synthesis of [ 508203-26-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 508203-26-7 ]

[ 508203-26-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 508203-26-7 ]
  • [ 135748-35-5 ]
YieldReaction ConditionsOperation in experiment
41.57 g With trichlorophosphate; at 80℃; General procedure: A mixture of 4-bromo-2,5-difluorobenzoic acid (11a, 53.28 g), thionyl chloride (165 mL) and DMF (0.87 mL) was stirred at 80 C for 1.5 h, and cooled down to room temperature. The mixture was evaporated in vacuo, and the resulting residue was dissolved in chloroform (300 mL). To the solution was added dropwise 28 wt % aqueous ammonia (300 mL) at 5 C, and the mixture was stirred at 5 C for 0.5 h. The mixture was extracted with chloroform, and the organic layer was dried. The desiccant was removed by filtration and the filtrate was evaporated in vacuo to obtain a pale yellow solid. The mixture of the obtained solid and phosphoryl chloride (195 mL) was stirred at 80 C for 2 h, and cooled down to room temperature. The mixture was evaporated in vacuo, and the resulting residue was treated with diethyl ether (500 mL) and ice-water (300 mL), then stirred at room temperature for 0.5 h. The mixture was extracted with diethyl ether and the organic layer was washed with saturated aqueous sodium hydrogen carbonate and brine, and then dried. The desiccant was removed by filtration and the filtrate was evaporated in vacuo to obtain 9h (41.57 g, 85%) as a pale yellow solid.
  • 2
  • [ 132794-07-1 ]
  • [ 508203-26-7 ]
 

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