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Chemical Structure| 50966-74-0 Chemical Structure| 50966-74-0

Structure of 50966-74-0

Chemical Structure| 50966-74-0

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Product Details of [ 50966-74-0 ]

CAS No. :50966-74-0
Formula : C9H8N2
M.W : 144.17
SMILES Code : C1(N2C=CC=C2)=NC=CC=C1
MDL No. :MFCD00023415

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Application In Synthesis of [ 50966-74-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 50966-74-0 ]

[ 50966-74-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50966-74-0 ]
  • [ 14135-38-7 ]
  • 2-{2,5-bis[(2-fluorophenyl)thio]-1H-pyrrol-1-yl}pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With copper(l) iodide; XPhos; In dimethyl sulfoxide; at 120℃; for 24h;Sealed tube; Schlenk technique; General procedure: Under an air atmosphere, a reaction tube was charged with 2-(1H-pyrrol-1-yl)pyridine (1a) (0.2 mmol), diphenyldisulfane (2a) (0.4 mmol), CuI (10 molpercent), XPhos (2-dicyclohexylphosphino-2?,4?,6?-triisopropylbiphenyl) (10 molpercent) and DMSO (2 mL). The vessel was sealed and heated at 120 °C (oil bath temperature) for 24 h and then cooled to room temperature. The reaction mixture was washed withs aturated Na2S2O3 (2 × 15 mL) and then brine (15 mL). After the aqueous layer had been extracted with EtOAc, the combined organic layers were dried over anhydrous Na2SO4 and evaporated under vacuum. The residue was purified by flash column chromatography (hexane/EtOAc) to afford the product 3a.
 

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