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Chemical Structure| 51135-96-7 Chemical Structure| 51135-96-7

Structure of 51135-96-7

Chemical Structure| 51135-96-7

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Product Details of [ 51135-96-7 ]

CAS No. :51135-96-7
Formula : C12H17NO
M.W : 191.27
SMILES Code : OC1(CC2=CC=CC=C2)CCNCC1
MDL No. :MFCD00023147
InChI Key :KJZBZOFESQSBCV-UHFFFAOYSA-N
Pubchem ID :98152

Safety of [ 51135-96-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P264-P270-P280-P301+P312+P330-P305+P351+P338-P337+P313-P501

Application In Synthesis of [ 51135-96-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51135-96-7 ]

[ 51135-96-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 63176-44-3 ]
  • [ 51135-96-7 ]
  • (4-benzyl-4-hydroxy-1-piperidyl)-(2-methyl-1H-indol-3-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20℃; To a stirred solution of 0.1 g (0.57 mmol) <strong>[63176-44-3]2-methyl-1H-indole-3-carboxylic acid</strong> in 10 ml CH2Cl2 were added 0.14 g (0.73 mmol) EDC, 0.10 g (0.73 mmol) HOBt, 90 μl (0.63 mmol) Et3N and 0.11 g (0.57 mmol) 4-benzyl-piperidin-4-ol. The mixture was stirred overnight at RT and then poured onto water and extracted with CH2Cl2. The combined organic phases were dried over Na2SO4 and concentrated in vacuo. Flash chromatography (ethyl acetate) afforded 0.15 g (75%) of (4-benzyl-4-hydroxy-piperidin-1-yl)-(2-methyl-1H-indol-3-yl)-methanone as a white solid. ES-MS m/e (%): 349 (M+H+).
 

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Related Functional Groups of
[ 51135-96-7 ]

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Related Parent Nucleus of
[ 51135-96-7 ]

Piperidines

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