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Chemical Structure| 51674-10-3 Chemical Structure| 51674-10-3

Structure of 51674-10-3

Chemical Structure| 51674-10-3

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Product Details of [ 51674-10-3 ]

CAS No. :51674-10-3
Formula : C12H17NO2
M.W : 207.27
SMILES Code : O=C(N(CC)CC)C1=CC=CC=C1OC
MDL No. :MFCD01010706

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Application In Synthesis of [ 51674-10-3 ]

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  • Downstream synthetic route of [ 51674-10-3 ]

[ 51674-10-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 51674-10-3 ]
  • [ 89694-46-2 ]
  • 2'-chloro-N,N-diethyl-3,5'-dimethoxybiphenyl-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate; In 1,4-dioxane; water; at 100℃; for 12h; To a solution of N,N-diethyl-2-methoxybenzamide (16) (0.862 g, 2.59 mmol)and <strong>[89694-46-2]2-chloro-5-methoxyphenylboronic acid</strong> (0.577 g, 3.11 mmol) indioxane/H2O (2:1, 50 mL) were added K2CO3 (1.4 g, 10.4 mmol) andPdCl2(dppf).CH2Cl2 (0.169 g, 8 molpercent). The resulting mixture was stirred for12 h at 100 °C. The reaction mixture was extracted with EtOAc (50 mL),washed with brine, dried (Na2SO4), subjected to filtration and concentrated under reduced pressure.Purification using flash column chromatography on silica gel (eluting with 4:6 hexanes/ethyl acetate)afforded product 17 (79percent, 0.710 g, 2.04 mmol) as a yellow oil
 

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